Ultrasmall Superparamagnetic Iron Oxide Nanoparticle for T2-Weighted Magnetic Resonance Imaging

2017 ◽  
Vol 9 (34) ◽  
pp. 28959-28966 ◽  
Author(s):  
Yaling Wang ◽  
Chao Xu ◽  
Yanan Chang ◽  
Lina Zhao ◽  
Kai Zhang ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Iron Oxide ◽  
Magnetic Resonance ◽  
Superparamagnetic Iron Oxide ◽  
Iron Oxide Nanoparticle ◽  
Resonance Imaging ◽  
Ultrasmall Superparamagnetic Iron Oxide ◽  
Weighted Magnetic Resonance Imaging ◽  
Oxide Nanoparticle ◽  
Superparamagnetic Iron Oxide Nanoparticle

scholarly journals Superparamagnetic Iron Oxide Nanoparticle Micelles Stabilized by Recombinant Oleosin for Targeted Magnetic Resonance Imaging

Small ◽  
2014 ◽  
Vol 11 (12) ◽  
pp. 1409-1413 ◽  
Author(s):  
Kevin B. Vargo ◽  
Ajlan Al Zaki ◽  
Robert Warden-Rothman ◽  
Andrew Tsourkas ◽  
Daniel A. Hammer
Keyword(s):  
Magnetic Resonance Imaging ◽  
Iron Oxide ◽  
Magnetic Resonance ◽  
Superparamagnetic Iron Oxide ◽  
Iron Oxide Nanoparticle ◽  
Resonance Imaging ◽  
Oxide Nanoparticle ◽  
Superparamagnetic Iron Oxide Nanoparticle

MR and Iron Magnetic Nanoparticles. Imaging Opportunities in Preclinical and Translational Research

2008 ◽  
Vol 94 (2) ◽  
pp. 226-233 ◽  
Author(s):  
Carlo Emanuele Neumaier ◽  
Gabriella Baio ◽  
Silvano Ferrini ◽  
Giorgio Corte ◽  
Antonio Daga
Keyword(s):  
Magnetic Resonance Imaging ◽  
Iron Oxide ◽  
Magnetic Resonance ◽  
Iron Oxide Nanoparticles ◽  
Superparamagnetic Iron Oxide ◽  
Iron Oxide Nanoparticle ◽  
Oxide Nanoparticles ◽  
Resonance Imaging ◽  
Ultrasmall Superparamagnetic Iron Oxide

Ultrasmall superparamagnetic iron oxide nanoparticles and magnetic resonance imaging provide a non-invasive method to detect and label tumor cells. These nanoparticles exhibit unique properties of superparamagnetism and can be utilized as excellent probes for magnetic resonance imaging. Most work has been performed using a magnetic resonance scanner with high field strength up to 7 T. Ultrasmall superparamagnetic iron oxide nanoparticles may represent a suitable tool for labeling molecular probes that target specific tumor-associated markers for in vitro and in vivo detection by magnetic resonance imaging. In our study, we demonstrated that magnetic resonance imaging at 1.5 T allows the detection of ultrasmall superparamagnetic iron oxide nanoparticle conjugated antibody specifically bound to human tumor cells in vitro and in vivo, and that the magnetic resonance signal intensity correlates with the concentration of ultrasmall superparamagnetic iron oxide nanoparticle antibody used and with the antigen density at the cell surface. The experiments were performed using two different means of targeting: direct and indirect magnetic tumor targeting. The imaging of tumor antigens using immunospecific contrast agents is a rapidly evolving field, which can potentially aid in early disease detection, monitoring of treatment efficacy, and drug development. Cell labeling by iron oxide nanoparticles has emerged as a potentially powerful tool to monitor trafficking of a large number of cells in the cell therapy field. We also studied the labeling of natural killer cells with iron nanoparticles to a level that would allow the detection of their signal intensity with a clinical magnetic resonance scanner at 1.5 T. Magnetic resonance imaging and iron magnetic nanoparticles are able to increase the accuracy and the specificity of imaging and represent new imaging opportunities in preclinical and translational research.

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