Dynamically Reversible Iron Oxide Nanoparticle Assemblies for Targeted Amplification of T1-Weighted Magnetic Resonance Imaging of Tumors

Nano Letters ◽  
2019 ◽  
Vol 19 (7) ◽  
pp. 4213-4220 ◽  
Author(s):  
Fangyuan Li ◽  
Zeyu Liang ◽  
Jianan Liu ◽  
Jihong Sun ◽  
Xi Hu ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Iron Oxide ◽  
Magnetic Resonance ◽  
Iron Oxide Nanoparticle ◽  
Resonance Imaging ◽  
Nanoparticle Assemblies ◽  
Weighted Magnetic Resonance Imaging ◽  
Oxide Nanoparticle

scholarly journals Three-Dimensional Iron Oxide Nanoparticle-Based Contrast-Enhanced Magnetic Resonance Imaging for Characterization of Cerebral Arteriogenesis in the Mouse Neocortex

2021 ◽  
Vol 15 ◽  
Author(s):  
Till de Bortoli ◽  
Philipp Boehm-Sturm ◽  
Stefan P. Koch ◽  
Melina Nieminen-Kelhä ◽  
Lars Wessels ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Iron Oxide ◽  
Magnetic Resonance ◽  
Iron Oxide Nanoparticle ◽  
Resonance Imaging ◽  
Non Invasive ◽  
Dsc Mri ◽  
Contrast Enhanced ◽  
Oxide Nanoparticle

Purpose: Subsurface blood vessels in the cerebral cortex have been identified as a bottleneck in cerebral perfusion with the potential for collateral remodeling. However, valid techniques for non-invasive, longitudinal characterization of neocortical microvessels are still lacking. In this study, we validated contrast-enhanced magnetic resonance imaging (CE-MRI) for in vivo characterization of vascular changes in a model of spontaneous collateral outgrowth following chronic cerebral hypoperfusion.Methods: C57BL/6J mice were randomly assigned to unilateral internal carotid artery occlusion or sham surgery and after 21 days, CE-MRI based on T2*-weighted imaging was performed using ultra-small superparamagnetic iron oxide nanoparticles to obtain subtraction angiographies and steady-state cerebral blood volume (ss-CBV) maps. First pass dynamic susceptibility contrast MRI (DSC-MRI) was performed for internal validation of ss-CBV. Further validation at the histological level was provided by ex vivo serial two-photon tomography (STP).Results: Qualitatively, an increase in vessel density was observed on CE-MRI subtraction angiographies following occlusion; however, a quantitative vessel tracing analysis was prone to errors in our model. Measurements of ss-CBV reliably identified an increase in cortical vasculature, validated by DSC-MRI and STP.Conclusion: Iron oxide nanoparticle-based ss-CBV serves as a robust, non-invasive imaging surrogate marker for neocortical vessels, with the potential to reduce and refine preclinical models targeting the development and outgrowth of cerebral collateralization.

scholarly journals Iron Oxide Nanoparticle-Micelles (ION-Micelles) for Sensitive (Molecular) Magnetic Particle Imaging and Magnetic Resonance Imaging

PLoS ONE ◽  
2013 ◽  
Vol 8 (2) ◽  
pp. e57335 ◽  
Author(s):  
Lucas W. E. Starmans ◽  
Dirk Burdinski ◽  
Nicole P. M. Haex ◽  
Rik P. M. Moonen ◽  
Gustav J. Strijkers ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Iron Oxide ◽  
Magnetic Resonance ◽  
Magnetic Particle ◽  
Iron Oxide Nanoparticle ◽  
Resonance Imaging ◽  
Magnetic Particle Imaging ◽  
Oxide Nanoparticle ◽  
Particle Imaging

scholarly journals Data from a terminated study on iron oxide nanoparticle magnetic resonance imaging for head and neck tumors

2020 ◽  
Vol 7 (1) ◽  
Author(s):  
Hesham Elhalawani ◽  
Musaddiq J. Awan ◽  
Yao Ding ◽  
Abdallah S. R. Mohamed ◽  
Ahmed K. Elsayes ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Iron Oxide ◽  
Magnetic Resonance ◽  
Head And Neck ◽  
Head And Neck Tumors ◽  
Iron Oxide Nanoparticle ◽  
Resonance Imaging ◽  
Neck Tumors ◽  
Oxide Nanoparticle
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