Coatings Releasing the Relaxin Peptide Analogue B7-33 Reduce Fibrotic Encapsulation

2019 ◽  
Vol 11 (49) ◽  
pp. 45511-45519 ◽  
Author(s):  
Nicholas G. Welch ◽  
Shayanti Mukherjee ◽  
Mohammed A. Hossain ◽  
Praveen Praveen ◽  
Jerome A. Werkmeister ◽  
...  
Keyword(s):  
Peptide Analogue

SYNTHESIS OF ESTRONE-OPIOID PEPTIDE ANALOGUE WITH EXPECTED ANALGESIC ACTIVITY

2010 ◽  
Vol 13 (2) ◽  
pp. 20-31
Author(s):  
Ayad A. AL-Hamashi ◽  
◽  
Kawkab Y. Saour ◽  
Keyword(s):  
Analgesic Activity ◽  
Opioid Peptide ◽  
Peptide Analogue

scholarly journals Improving the Utility of a Dynorphin Peptide Analogue Using Mannosylated Glycoliposomes

2021 ◽  
Vol 22 (15) ◽  
pp. 7996
Author(s):  
Jordan D. Lewicky ◽  
Nya L. Fraleigh ◽  
Alexandrine L. Martel ◽  
Thi M.-D. Nguyen ◽  
Peter W. Schiller ◽  
...  
Keyword(s):  
Targeted Delivery ◽  
Delivery Systems ◽  
Kappa Opioid Receptor ◽  
Antagonist Activity ◽  
Peptide Analogue ◽  
Nanoparticle Delivery ◽  
The Central Nervous System ◽  
Metabolic Degradation ◽  
Distribution Studies

Peptide therapeutics offer numerous advantages in the treatment of diseases and disorders of the central nervous system (CNS). However, they are not without limitations, especially in terms of their pharmacokinetics where their metabolic lability and low blood–brain barrier penetration hinder their application. Targeted nanoparticle delivery systems are being tapped for their ability to improve the delivery of therapeutics into the brain non-invasively. We have developed a family of mannosylated glycoliposome delivery systems for targeted drug delivery applications. Herein, we demonstrate via in vivo distribution studies the potential of these glycoliposomes to improve the utility of CNS active therapeutics using dynantin, a potent and selective dynorphin peptide analogue antagonist of the kappa opioid receptor (KOR). Glycoliposomal entrapment protected dynantin against known rapid metabolic degradation and ultimately improved brain levels of the peptide by approximately 3–3.5-fold. Moreover, we linked this improved brain delivery with improved KOR antagonist activity by way of an approximately 30–40% positive modulation of striatal dopamine levels 20 min after intranasal administration. Overall, the results clearly highlight the potential of our glycoliposomes as a targeted delivery system for therapeutic agents of the CNS.

Hydrophobic forces are responsible for the folding of a highly potent natriuretic peptide analogue at a membrane mimetic surface: An NMR study

Biopolymers ◽  
1997 ◽  
Vol 42 (1) ◽  
pp. 37-48 ◽  
Author(s):  
Katharine A. Carpenter ◽  
Brian C. Wilkes ◽  
André De Léan ◽  
Alain Fournier ◽  
Peter W. Schiller
Keyword(s):  
Natriuretic Peptide ◽  
Peptide Analogue ◽  
Nmr Study ◽  
Membrane Mimetic

Synthesis and structural investigation of 2-aminomethyl-3-(4-methoxy-phenyl)-propionic acid containing a peptide analogue of the amyloidogenic AS(6–7) sequence: inhibition of fibril formation

2017 ◽  
Vol 15 (19) ◽  
pp. 4218-4225 ◽  
Author(s):  
Arpita Paikar ◽  
Mintu Debnath ◽  
Debasish Podder ◽  
Supriya Sasmal ◽  
Debasish Haldar
Keyword(s):  
Amino Acid ◽  
Propionic Acid ◽  
Structural Investigation ◽  
Fibril Formation ◽  
Peptide Analogue ◽  
Phenyl Propionic Acid

The incorporation of a β-amino acid, namely 2-aminomethyl-3-(4-methoxy-phenyl)-propionic acid, inhibits amyloid-like fibril formation.

scholarly journals Recombinant expressed vasoactive intestinal peptide analogue ameliorates TNBS-induced colitis in rats

2018 ◽  
Vol 24 (6) ◽  
pp. 706-715 ◽  
Author(s):  
Chun-Lan Xu ◽  
Yu Guo ◽  
Lei Qiao ◽  
Li Ma ◽  
Yi-Yi Cheng
Keyword(s):  
Vasoactive Intestinal Peptide ◽  
Peptide Analogue

scholarly journals Ghrelin Peptide Analogue

2020 ◽  
Author(s):  
Keyword(s):  
Peptide Analogue

An Amphipathic α -Helical Synthetic Peptide Analogue of Melittin Inhibits Herpes Simplex Virus-1 (HSV-1)-Induced Cell Fusion and Virus Spread

Peptides ◽  
1997 ◽  
Vol 18 (2) ◽  
pp. 177-183 ◽  
Author(s):  
A. Baghian ◽  
J. Jaynes ◽  
F. Enright ◽  
K.G. Kousoulas
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Cell Fusion ◽  
Synthetic Peptide ◽  
Virus Spread ◽  
Herpes Simplex Virus 1 ◽  
Peptide Analogue ◽  
Simplex Virus ◽  
Hsv 1

The effects of synthetic Azurocidin peptide analogue on Staphylococcus aureus bacterium

2013 ◽  
Author(s):  
J. Hu ◽  
P. Peidaee ◽  
E. Elshagmani ◽  
T. Istivan ◽  
E. Pirogova
Keyword(s):  
Staphylococcus Aureus ◽  
Peptide Analogue
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