scholarly journals Tunable Heteroassembly of a Plant Pseudoenzyme–Enzyme Complex

2021 ◽  
Author(s):  
Irina V. Novikova ◽  
Mowei Zhou ◽  
Chen Du ◽  
Marcelina Parra ◽  
Doo Nam Kim ◽  
...  
Keyword(s):  
Enzyme Complex

Long-term efficacy of a new medical device containing Fernblock® and DNA repair enzyme complex in the treatment and prevention of cancerization field in patients with actinic keratosis.

2019 ◽  
Vol 2 (02) ◽  
pp. 80-89
Author(s):  
Blanca De Unamuno Bustos ◽  
Natalia Chaparr´´o Aguilera ◽  
Inmaculada Azorín García ◽  
Anaid Calle Andrino ◽  
Margarita Llavador Ros ◽  
...  
Keyword(s):  
Dna Damage ◽  
Dna Repair ◽  
Medical Device ◽  
Actinic Keratosis ◽  
Statistical Significance ◽  
Dna Lesions ◽  
Enzyme Complex ◽  
Repair Enzyme ◽  
P53 Expression ◽  
Cancerization Field

Actinic keratosis (AKs) are part of the cancerization field, a region adjacent to AKs containing subclinical and histologically abnormal epidermal tissue due to Ultraviolet (UV)-induced DNA damage. The photoproducts as consequence of DNA damage induced by UV are mainly cyclobutane pyrimidine dimers (CPDs). Fernblock® demonstrated in previous studies significant reduction of the number of CPDs induced by UV radiation. Photolyases are a specific group of enzymes that remove the major UV-induced DNA lesions by a mechanism called photo-reactivation. A monocentric, prospective, controlled, and double blind interventional study was performed to evaluate the effect of a new medical device (NMD) containing a DNA-repair enzyme complex (photolyases, endonucleases and glycosilases), a combination of UV-filters, and Fernblock® in the treatment of the cancerization field in 30 AK patients after photodynamic therapy. Patients were randomized into two groups: patients receiving a standard sunscreen (SS) andpatients receiving the NMD. Clinical, dermoscopic, reflectance confocal microscopy (RCM) and histological evaluations were performed. An increase of AKs was noted in all groups after three months of PDT without significant differences between them (p=0.476). A significant increase in the number of AKs was observed in SS group after six (p=0.026) and twelve months of PDT (p=0.038); however, this increase did not reach statistical significance in the NMD group. Regarding RCM evaluation, honeycomb pattern assessment after twelve months of PDT showed significant differences in the extension and grade of the atypia in the NMD group compared to SS group (p=0.030 and p=0.026, respectively). Concerning histopathological evaluation, keratinocyte atypia grade improved from baseline to six months after PDT in all the groups, with no statistically significant differences between the groups. Twelve months after PDT, p53 expression was significantly lower in the NMD group compared to SS group (p=0.028). The product was well-tolerated, with no serious adverse events reported. Our results provide evidence of the utility of this NMD in the improvement of the cancerization field and in the prevention of the development of new AKs.  

Matrix metalloproteinases in stroke

2017 ◽  
pp. 110-117
Author(s):  
А.А. Пальцын
Keyword(s):  
Matrix Metalloproteinases ◽  
Enzyme System ◽  
Enzyme Complex ◽  
Pathogenic Factors ◽  
Pathogenic Action ◽  
Activity Of Enzymes ◽  
Living Tissues ◽  
Current Reconstruction ◽  
Metalloproteinase Activity

Матриксные металлопротеиназы - ферментный комплекс, необходимый для сохранения гомеостаза. Он участник нормальной, постоянно текущей реконструкции всех живых тканей. Действие патогенных факторов нарушает слаженную работу этого комплекса. Часто нарушение выражается излишней активностью ферментов, усиливающей патогенное действие. Однако и заживление, форсированное новообразование тканевых элементов, может происходить только при повышенной, в сравнении с нормой, активности металлопротеиназ. Такая ситуация требует от медицины умения разумно вмешиваться в работу ферментной системы. В статье представлены некоторые результаты этих вмешательств. Matrix metalloproteinases - enzyme complex necessary for maintenance of the homeostasis. He is a participant of normal, constantly current reconstruction of all living tissues. Action of pathogenic factors breaks harmonious work of this complex. Often violation is expressed by the excessive activity of enzymes amplifying pathogenic action. However and healing, which is accelerated new growth of tissue elements, can happen only at raised, compared with norm, metalloproteinase activity. Such situation demands from medicine of ability participate reasonably in work of enzyme system. The article presents some of the results of these actions.

Comparison of proteolytic activities of the enzyme complex from mammalian pancreas and pancreatin

2000 ◽  
Vol 36 (4) ◽  
pp. 363-367 ◽  
Author(s):  
A. V. Berdutina ◽  
A. D. Neklyudov ◽  
A. I. Ivankin ◽  
B. S. Karpo ◽  
S. I. Mitaleva
Keyword(s):  
Enzyme Complex ◽  
Proteolytic Activities

scholarly journals Rapid, convenient, and highly sensitive detection of human hemoglobin in serum using a high-affinity bivalent antibody–enzyme complex

Talanta ◽  
2021 ◽  
pp. 122638
Author(s):  
Daimei Miura ◽  
Hayato Kimura ◽  
Wakako Tsugawa ◽  
Kazunori Ikebukuro ◽  
Koji Sode ◽  
...  
Keyword(s):  
Sensitive Detection ◽  
Enzyme Complex ◽  
Human Hemoglobin ◽  
High Affinity ◽  
Highly Sensitive ◽  
Highly Sensitive Detection

scholarly journals Studies on the yeast fatty acid synthetase. Subunit composition and structural organization of a large multifunctional enzyme complex.

1978 ◽  
Vol 253 (12) ◽  
pp. 4464-4475
Author(s):  
J.K. Stoops ◽  
E.S. Awad ◽  
M.J. Arslanian ◽  
S. Gunsberg ◽  
S.J. Wakil ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Structural Organization ◽  
Fatty Acid Synthetase ◽  
Subunit Composition ◽  
Enzyme Complex ◽  
Multifunctional Enzyme
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