Structure–Activity Relationship Studies of Functionally Selective Kappa Opioid Receptor Agonists that Modulate ERK 1/2 Phosphorylation While Preserving G Protein Over βArrestin2 Signaling Bias

Kimberly M. Lovell; Kevin J. Frankowski; Edward L. Stahl; Stephen R. Slauson; Euna Yoo; Thomas E. Prisinzano; Jeffrey Aubé; Laura M. Bohn

doi:10.1021/acschemneuro.5b00092

Structure–Activity Relationship Studies of Functionally Selective Kappa Opioid Receptor Agonists that Modulate ERK 1/2 Phosphorylation While Preserving G Protein Over βArrestin2 Signaling Bias

ACS Chemical Neuroscience ◽

10.1021/acschemneuro.5b00092 ◽

2015 ◽

Vol 6 (8) ◽

pp. 1411-1419 ◽

Cited By ~ 36

Author(s):

Kimberly M. Lovell ◽

Kevin J. Frankowski ◽

Edward L. Stahl ◽

Stephen R. Slauson ◽

Euna Yoo ◽

...

Keyword(s):

G Protein ◽

Opioid Receptor ◽

Structure Activity Relationship ◽

Kappa Opioid Receptor ◽

Activity Relationship ◽

Kappa Opioid ◽

Receptor Agonists ◽

Structure Activity ◽

Opioid Receptor Agonists

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Faculty Opinions recommendation of Structure-activity relationship studies of functionally selective kappa opioid receptor agonists that modulate ERK 1/2 phosphorylation while preserving G protein over βarrestin2 signaling bias.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.725444384.793506439 ◽

2015 ◽

Author(s):

John Lowe

Keyword(s):

G Protein ◽

Opioid Receptor ◽

Structure Activity Relationship ◽

Kappa Opioid Receptor ◽

Activity Relationship ◽

Kappa Opioid ◽

Receptor Agonists ◽

Structure Activity ◽

Opioid Receptor Agonists

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Correction to “Structure–Activity Relationship Studies of Functionally Selective Kappa Opioid Receptor Agonists that Modulate ERK 1/2 Phosphorylation While Preserving G Protein Over βArrestin2 Signaling Bias”

ACS Chemical Neuroscience ◽

10.1021/acschemneuro.7b00157 ◽

2017 ◽

Vol 8 (7) ◽

pp. 1628-1628

Author(s):

Kimberly M. Lovell ◽

Kevin J. Frankowski ◽

Edward L. Stahl ◽

Stephen R. Slauson ◽

Euna Yoo ◽

...

Keyword(s):

G Protein ◽

Opioid Receptor ◽

Structure Activity Relationship ◽

Kappa Opioid Receptor ◽

Activity Relationship ◽

Kappa Opioid ◽

Receptor Agonists ◽

Structure Activity ◽

Opioid Receptor Agonists

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Structure–activity relationship investigation of triazole-based kappa opioid receptor agonists

Medicinal Chemistry Research ◽

10.1007/s00044-021-02746-1 ◽

2021 ◽

Author(s):

Kevin J. Frankowski ◽

Tarsis Brust ◽

Kimberly M. Lovell ◽

Euna Yoo ◽

Laura M. Bohn ◽

...

Keyword(s):

Opioid Receptor ◽

Structure Activity Relationship ◽

Kappa Opioid Receptor ◽

Activity Relationship ◽

Kappa Opioid ◽

Receptor Agonists ◽

Structure Activity ◽

Opioid Receptor Agonists

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Discovery, structure–activity relationship studies, and anti-nociceptive effects of 1-phenyl-3,6,6-trimethyl-1,5,6,7-tetrahydro-4H-indazol-4-one as novel opioid receptor agonists

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2014.07.012 ◽

2014 ◽

Vol 22 (17) ◽

pp. 4694-4703 ◽

Cited By ~ 8

Author(s):

Ming-Fu Cheng ◽

Li-Chin Ou ◽

Shu-Chun Chen ◽

Wan-Ting Chang ◽

Ping-Yee Law ◽

...

Keyword(s):

Opioid Receptor ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Receptor Agonists ◽

Structure Activity ◽

Opioid Receptor Agonists

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Design, Synthesis, and Structure–Activity Relationship Exploration of Alkyl/Phenylalkyl Piperidine Analogues as Novel Highly Potent and Selective μ Opioid Receptor Agonists

ACS Chemical Neuroscience ◽

10.1021/acschemneuro.0c00487 ◽

2020 ◽

Author(s):

Huoming Huang ◽

Xinwei Li ◽

Wei Guo ◽

Chen Zhu ◽

Yuanyuan Qian ◽

...

Keyword(s):

Opioid Receptor ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Design Synthesis ◽

Receptor Agonists ◽

Structure Activity ◽

Μ Opioid Receptor ◽

Opioid Receptor Agonists

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Discovery, structure-activity relationship studies, and anti-nociceptive effects of N-(1,2,3,4-tetrahydro-1-isoquinolinylmethyl)benzamides as novel opioid receptor agonists

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2016.09.003 ◽

2017 ◽

Vol 126 ◽

pp. 202-217 ◽

Cited By ~ 6

Author(s):

Sheng-Ren Chen ◽

Yi-Yu Ke ◽

Teng-Kuang Yeh ◽

Shu-Yu Lin ◽

Li-Chin Ou ◽

...

Keyword(s):

Opioid Receptor ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Receptor Agonists ◽

Structure Activity ◽

Opioid Receptor Agonists

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Design and Synthesis of a Piperidinone Scaffold as an Analgesic through Kappa-Opioid Receptor: Structure–Activity Relationship Study of Matrine Alkaloids

Chemical and Pharmaceutical Bulletin ◽

10.1248/cpb.c15-00962 ◽

2016 ◽

Vol 64 (5) ◽

pp. 410-419 ◽

Cited By ~ 6

Author(s):

Hiroyoshi Teramoto ◽

Takayasu Yamauchi ◽

Yasushi Terado ◽

Sanae Odagiri ◽

Shigeru Sasaki ◽

...

Keyword(s):

Opioid Receptor ◽

Structure Activity Relationship ◽

Kappa Opioid Receptor ◽

Activity Relationship ◽

Kappa Opioid ◽

Design And Synthesis ◽

Receptor Structure ◽

Structure Activity ◽

Relationship Study

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Molecular Docking, Molecular Dynamics, and Structure–Activity Relationship Explorations of 14-Oxygenated N-Methylmorphinan-6-ones as Potent μ-Opioid Receptor Agonists

ACS Chemical Neuroscience ◽

10.1021/acschemneuro.6b00460 ◽

2017 ◽

Vol 8 (6) ◽

pp. 1327-1337 ◽

Cited By ~ 11

Author(s):

Stefan M. Noha ◽

Helmut Schmidhammer ◽

Mariana Spetea

Keyword(s):

Molecular Dynamics ◽

Molecular Docking ◽

Opioid Receptor ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Receptor Agonists ◽

Structure Activity ◽

Μ Opioid Receptor ◽

Opioid Receptor Agonists

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Nascent structure–activity relationship study of a diastereomeric series of kappa opioid receptor antagonists derived from CJ-15,208

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2009.04.105 ◽

2009 ◽

Vol 19 (13) ◽

pp. 3647-3650 ◽

Cited By ~ 24

Author(s):

Roland E. Dolle ◽

Mathieu Michaut ◽

Blanca Martinez-Teipel ◽

Pamela R. Seida ◽

Christopher W. Ajello ◽

...

Keyword(s):

Opioid Receptor ◽

Structure Activity Relationship ◽

Kappa Opioid Receptor ◽

Activity Relationship ◽

Receptor Antagonists ◽

Kappa Opioid ◽

Structure Activity ◽

Opioid Receptor Antagonists ◽

Relationship Study

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Structure-Activity Relationship Studies of Dynorphin A Analogs at the Kappa Opioid Receptor

Peptides 2015, Proceedings of the 24th American Peptide Symposium ◽

10.17952/24aps.2015.096 ◽

2015 ◽

Author(s):

Cyf N. Ramos Colon ◽

Yeon Sun Lee ◽

Sara M. Hall ◽

Josephine Lai ◽

Frank Porreca ◽

...

Keyword(s):

Opioid Receptor ◽

Structure Activity Relationship ◽

Kappa Opioid Receptor ◽

Activity Relationship ◽

Dynorphin A ◽

Kappa Opioid ◽

Structure Activity

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