scholarly journals Discovery of Potent and Noncovalent Reversible EGFR Kinase Inhibitors of EGFRL858R/T790M/C797S

2019 ◽  
Vol 10 (6) ◽  
pp. 869-873 ◽  
Author(s):  
Qiannan Li ◽  
Tao Zhang ◽  
Shiliang Li ◽  
Linjiang Tong ◽  
Junyu Li ◽  
...  
Keyword(s):  
Kinase Inhibitors ◽  
Egfr Kinase

scholarly journals Platination of cysteine by an epidermal growth factor receptor kinase-targeted hybrid agent

2018 ◽  
Vol 54 (54) ◽  
pp. 7479-7482 ◽  
Author(s):  
Mu Yang ◽  
Hanzhi Wu ◽  
Julie Chu ◽  
Lucas A. Gabriel ◽  
Y. Kim ◽  
...  
Keyword(s):  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Kinase Inhibitors ◽  
Growth Factor Receptor ◽  
Cysteine Residue ◽  
Receptor Kinase ◽  
Epidermal Growth ◽  
Hybrid Agent ◽  
Egfr Kinase

Platinum-modified tyrosine kinase inhibitors show strong and selective EGFR kinase binding and form adducts with a pharmacologically relevant cysteine residue.

Design, synthesis and biological evaluation of potent EGFR kinase inhibitors against 19D/T790M/C797S mutation

2020 ◽  
Vol 30 (16) ◽  
pp. 127327
Author(s):  
Zhicheng Su ◽  
Tingyuan Yang ◽  
Jie Wang ◽  
Mengzhen Lai ◽  
Linjiang Tong ◽  
...  
Keyword(s):  
Kinase Inhibitors ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation ◽  
Egfr Kinase

scholarly journals Differential Sensitivity of Glioma- versus Lung Cancer–Specific EGFR Mutations to EGFR Kinase Inhibitors

2012 ◽  
Vol 2 (5) ◽  
pp. 458-471 ◽  
Author(s):  
Igor Vivanco ◽  
H. Ian Robins ◽  
Daniel Rohle ◽  
Carl Campos ◽  
Christian Grommes ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Kinase Inhibitors ◽  
Differential Sensitivity ◽  
Egfr Mutations ◽  
Egfr Kinase

scholarly journals Reactivation of ERK Signaling Causes Resistance to EGFR Kinase Inhibitors

2012 ◽  
Vol 2 (10) ◽  
pp. 934-947 ◽  
Author(s):  
Dalia Ercan ◽  
Chunxiao Xu ◽  
Masahiko Yanagita ◽  
Calixte S. Monast ◽  
Christine A. Pratilas ◽  
...  
Keyword(s):  
Kinase Inhibitors ◽  
Erk Signaling ◽  
Egfr Kinase

MET and AXL Inhibitor NPS-1034 Exerts Efficacy against Lung Cancer Cells Resistant to EGFR Kinase Inhibitors Because of MET or AXL Activation

2013 ◽  
Vol 74 (1) ◽  
pp. 253-262 ◽  
Author(s):  
Jin Kyung Rho ◽  
Yun Jung Choi ◽  
Seon Ye Kim ◽  
Tae Won Kim ◽  
Eun Kyung Choi ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Kinase Inhibitors ◽  
Lung Cancer Cells ◽  
Egfr Kinase
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