Intranasal Administration of Self-Oriented Nanocarriers Based on Therapeutic Exosomes for Synergistic Treatment of Parkinson’s Disease

ACS Nano ◽  
2022 ◽  
Author(s):  
Huan Peng ◽  
Yan Li ◽  
Weihong Ji ◽  
Ruichen Zhao ◽  
Zhiguo Lu ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Intranasal Administration

Intranasal administration of endometrial mesenchymal stem cells as a suitable approach for Parkinson’s disease therapy

2019 ◽  
Vol 46 (4) ◽  
pp. 4293-4302 ◽  
Author(s):  
Saeid Bagheri-Mohammadi ◽  
Behrang Alani ◽  
Mohammad Karimian ◽  
Rana Moradian-Tehrani ◽  
Mahdi Noureddini
Keyword(s):  
Parkinson’S Disease ◽  
Stem Cells ◽  
Parkinson's Disease ◽  
Mesenchymal Stem Cells ◽  
Intranasal Administration ◽  
Disease Therapy

P2.209 Single intranasal administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in C57BL/6 mice models early preclinical phase of Parkinson's disease

2009 ◽  
Vol 15 ◽  
pp. S146
Author(s):  
R. Raisman Vozari ◽  
A. Aguiar ◽  
A. Rojas-Mayorquin ◽  
C. Figueiredo ◽  
F. Matheus ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Intranasal Administration ◽  
Preclinical Phase

Odorranalectin-conjugated nanoparticles: Preparation, brain delivery and pharmacodynamic study on Parkinson's disease following intranasal administration

2011 ◽  
Vol 151 (2) ◽  
pp. 131-138 ◽  
Author(s):  
Ziyi Wen ◽  
Zhiqiang Yan ◽  
Kaili Hu ◽  
Zhiqing Pang ◽  
Xufei Cheng ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Intranasal Administration ◽  
Brain Delivery ◽  
Pharmacodynamic Study

Single Intranasal Administration of 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine in C57BL/6 Mice Models Early Preclinical Phase of Parkinson’s Disease

2009 ◽  
Vol 17 (2) ◽  
pp. 114-129 ◽  
Author(s):  
Rui D. S. Prediger ◽  
Aderbal S. Aguiar ◽  
Argelia Esperanza Rojas-Mayorquin ◽  
Claudia P. Figueiredo ◽  
Filipe C. Matheus ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Intranasal Administration ◽  
Preclinical Phase

The establishment of a mouse model of Parkinson’s disease induced by intranasal administration of LPS

2017 ◽  
Vol 381 ◽  
pp. 198-199
Author(s):  
G.B. Song ◽  
G.P. Xi ◽  
Y.H. Li ◽  
K.J. Li ◽  
J.C. Liu ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Mouse Model ◽  
Intranasal Administration

scholarly journals Effect of Intranasal Administration of Dopamine on Odor Perception in Rats with Nigrostriatal Dysfunction

2021 ◽  
Vol 6 (3) ◽  
pp. 333-339
Author(s):  
N. O. Levicheva ◽  
◽  
O. G. Berchenko ◽  
Y. Y. Ilina ◽  
◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Motor Skills ◽  
Intranasal Administration ◽  
Olfactory Dysfunction ◽  
Fine Motor ◽  
Fine Motor Skills ◽  
Olfactory Sensitivity ◽  
Small Doses ◽  
The Brain

In recent years, there has been a growing interest in finding early predictors of Parkinson’s disease. In this regard, it is worth noting the olfactory dysfunction, which is associated with the death of neurons in the structures of the limbic system of the brain and a decrease in dopamine levels in the striatum. It was found that most patients with Parkinson’s disease have a clear olfactory dysfunction in the form of impaired differentiation and identification of odors. It has been suggested that the use of low doses of dopamine in the early stages of Parkinson’s disease will stop the progression of central nervous system disorders. The purpose of the study was to investigate the effect of intranasal administration of small doses of dopamine on the early manifestations of fine motor skills and olfactory sensory system function in nigrostriatal dysfunction in rats. Materials and methods. The experiments were performed on 2 groups of animals (n=14) with nigrostriatal dysfunction, which was modulated by partial bilateral electrical damage to the compact part of the substantia nigra. Stereotactic coordinates of the substantia nigra area were determined from the brain maps of rats by Fifkova and Marshall (quoted by Buresh), which corresponded to the distance from the point of intersection of the sagittal suture with bregma: F=5.5 mm, L=1.7 mm, H=9.0 mm. Rats of the first group (n=8) were intranasally administered with small doses of dopamine, and rats of the second group (n=6) were a comparison group. The fine motor skills of the forelimbs and the functional state of the olfactory system were studied when rats were presented with different odorants: emotionally positive (isovaleric acid) and emotionally negative (lemon essential oil) odorants. Results and discussion. The dynamics of the development of nigrostriatal dysfunction revealed a decrease in coordinated motor activity of the forelimbs, muscles of the oral pole and tongue and increased olfactory sensitivity to emotionally negative odorant (lemon essential oil) and loss of 40% of animals’ olfactory sensitivity to emotionally positive isovaleric odor. Conclusion. Prolonged intranasal administration of low doses of dopamine for 10 days to rats with nigrostriatal dysfunction resulted in a 26.2% increase in the activity of fine motor skills of the forelimbs, oral poles and tongue. In these rats, recovery of olfactory sensitivity to the perception of the smell of emotionally negative odorant was found. The action of the emotionally positive stimulus of isovaleric acid revealed an increase in olfactory sensitivity in 75% of animals to the level of baseline values and a decrease in the threshold of sensitivity to it, which was reflected in an increase in the number of approaches and time of odorant research

Magnetic Targeting of Human Olfactory Mucosa Stem Cells Following Intranasal Administration: a Novel Approach to Parkinson’s Disease Treatment

2021 ◽  
Author(s):  
Sara Simorgh ◽  
Zohreh Bagher ◽  
Mohammad Farhadi ◽  
Seyed Kamran Kamrava ◽  
Mahdi Eskandarian Boroujeni ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Stem Cells ◽  
Parkinson's Disease ◽  
Intranasal Administration ◽  
Olfactory Mucosa ◽  
Magnetic Targeting ◽  
Disease Treatment ◽  
Novel Approach ◽  
Human Olfactory Mucosa

Intranasal Administration of Chitosan-Coated Nanostructured Lipid Carriers Loaded with GDNF Improves Behavioral and Histological Recovery in a Partial Lesion Model of Parkinson's Disease

2016 ◽  
Vol 12 (12) ◽  
pp. 2220-2280 ◽  
Author(s):  
O. Gartziandia ◽  
E. Herrán ◽  
J. A. Ruiz-Ortega ◽  
C. Miguelez ◽  
M. Igartua ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Intranasal Administration ◽  
Nanostructured Lipid Carriers ◽  
Partial Lesion

Intranasal Administration of GDNF Protects Against Neural Apoptosis in a Rat Model of Parkinson’s Disease Through PI3K/Akt/GSK3β Pathway

2017 ◽  
Vol 42 (5) ◽  
pp. 1366-1374 ◽  
Author(s):  
Peijian Yue ◽  
Lin Gao ◽  
Xuejing Wang ◽  
Xuebing Ding ◽  
Junfang Teng
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Rat Model ◽  
Intranasal Administration ◽  
Neural Apoptosis
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