scholarly journals Optimizing Mannose “Click” Conjugation to Polymeric Nanoparticles for Targeted siRNA Delivery to Human and Murine Macrophages

ACS Omega ◽  
2019 ◽  
Vol 4 (16) ◽  
pp. 16756-16767 ◽  
Author(s):  
Evan B. Glass ◽  
Shirin Masjedi ◽  
Stephanie O. Dudzinski ◽  
Andrew J. Wilson ◽  
Craig L. Duvall ◽  
...  
Keyword(s):  
Polymeric Nanoparticles ◽  
Sirna Delivery ◽  
Murine Macrophages

scholarly journals Confocal microscopy for the analysis of siRNA delivery by polymeric nanoparticles

2010 ◽  
Vol 73 (9) ◽  
pp. 878-885 ◽  
Author(s):  
Amanda M. Portis ◽  
Georgina Carballo ◽  
Gregory L. Baker ◽  
Christina Chan ◽  
S. Patrick Walton
Keyword(s):  
Confocal Microscopy ◽  
Polymeric Nanoparticles ◽  
Sirna Delivery

Preparation of Neutrally-charged, pH-responsive Polymeric Nanoparticles for Cytosolic siRNA Delivery

10.3791/59549 ◽  
2019 ◽  
Author(s):  
John Hendershot ◽  
Adam E. Smith ◽  
Thomas A. Werfel
Keyword(s):  
Polymeric Nanoparticles ◽  
Sirna Delivery ◽  
Ph Responsive

scholarly journals Maghemite-containing PLGA–PEG-based polymeric nanoparticles for siRNA delivery: toxicity and silencing evaluation

RSC Advances ◽  
2017 ◽  
Vol 7 (43) ◽  
pp. 26912-26920 ◽  
Author(s):  
Emmanuel Lellouche ◽  
Erica Locatelli ◽  
Liron Limor Israel ◽  
Maria Naddaka ◽  
Ella Kurlander ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Contrast Agent ◽  
Therapeutic Approach ◽  
Polymeric Nanoparticles ◽  
Sirna Delivery ◽  
Mri Contrast Agent ◽  
Mri Contrast ◽  
P Gene ◽  
Theranostic Nanoparticles

Gene therapy based on siRNA has emerged as an exciting new therapeutic approach. In this work, incorporation of PEI into PLGA-b-PEG and encapsulation of magnetic NPs as MRI contrast agent, resulted in unique theranostic nanoparticles.

scholarly journals In vivo endothelial siRNA delivery using polymeric nanoparticles with low molecular weight

2014 ◽  
Vol 9 (8) ◽  
pp. 648-655 ◽  
Author(s):  
James E. Dahlman ◽  
Carmen Barnes ◽  
Omar F. Khan ◽  
Aude Thiriot ◽  
Siddharth Jhunjunwala ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Polymeric Nanoparticles ◽  
Sirna Delivery ◽  
Low Molecular Weight

Polymeric Nanocarriers for siRNA Delivery to Murine Macrophages

2014 ◽  
Vol 14 (8) ◽  
pp. 1096-1105 ◽  
Author(s):  
Diane C. Forbes ◽  
Nicholas A. Peppas
Keyword(s):  
Sirna Delivery ◽  
Polymeric Nanocarriers ◽  
Murine Macrophages

scholarly journals Photocrosslinked Bioreducible Polymeric Nanoparticles for Enhanced Systemic siRNA Delivery as Cancer Therapy

2021 ◽  
pp. 2009768
Author(s):  
Johan Karlsson ◽  
Stephany Y. Tzeng ◽  
Shayan Hemmati ◽  
Kathryn M. Luly ◽  
Olivia Choi ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Polymeric Nanoparticles ◽  
Sirna Delivery

Nanocarrier Mediated siRNA Delivery Targeting Stem Cell Differentiation

2020 ◽  
Vol 15 (2) ◽  
pp. 155-172 ◽  
Author(s):  
Fiona Fernandes ◽  
Pooja Kotharkar ◽  
Adrija Chakravorty ◽  
Meenal Kowshik ◽  
Indrani Talukdar
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Viral Vectors ◽  
Therapeutic Potential ◽  
Transfection Efficiency ◽  
Polymeric Nanoparticles ◽  
Sirna Delivery ◽  
Stem Cell Differentiation

Stem cell-based regenerative medicine holds exceptional therapeutic potential and hence the development of efficient techniques to enhance control over the rate of differentiation has been the focus of active research. One of the strategies to achieve this involves delivering siRNA into stem cells and exploiting the RNA interference (RNAi) mechanism. Transport of siRNA across the cell membrane is a challenge due to its anionic property, especially in primary human cells and stem cells. Moreover, naked siRNA incites immune responses, may cause off-target effects, exhibits low stability and is easily degraded by endonucleases in the bloodstream. Although siRNA delivery using viral vectors and electroporation has been used in stem cells, these methods demonstrate low transfection efficiency, cytotoxicity, immunogenicity, events of integration and may involve laborious customization. With the advent of nanotechnology, nanocarriers which act as novel gene delivery vehicles designed to overcome the problems associated with safety and practicality are being developed. The various nanomaterials that are currently being explored and discussed in this review include liposomes, carbon nanotubes, quantum dots, protein and peptide nanocarriers, magnetic nanoparticles, polymeric nanoparticles, etc. These nanodelivery agents exhibit advantages such as low immunogenic response, biocompatibility, design flexibility allowing for surface modification and functionalization, and control over the surface topography for achieving the desired rate of siRNA delivery and improved gene knockdown efficiency. This review also includes discussion on siRNA co-delivery with imaging agents, plasmid DNA, drugs etc. to achieve combined diagnostic and enhanced therapeutic functionality, both for in vitro and in vivo applications.

scholarly journals Matrix Metalloproteinase Responsive, Proximity-Activated Polymeric Nanoparticles for siRNA Delivery

2013 ◽  
Vol 23 (24) ◽  
pp. 3040-3052 ◽  
Author(s):  
Hongmei Li ◽  
Shann S. Yu ◽  
Martina Miteva ◽  
Christopher E. Nelson ◽  
Thomas Werfel ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Polymeric Nanoparticles ◽  
Sirna Delivery

scholarly journals Applications of Lipidic and Polymeric Nanoparticles for siRNA Delivery

2019 ◽  
Author(s):  
Behiye Şenel ◽  
Gülay Büyükköroğlu
Keyword(s):  
Polymeric Nanoparticles ◽  
Sirna Delivery
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