The Role of Copper in Topa Quinone Biogenesis and Catalysis, as Probed by Azide Inhibition of a Copper Amine Oxidase from Yeast†

Biochemistry ◽  
2001 ◽  
Vol 40 (9) ◽  
pp. 2954-2963 ◽  
Author(s):  
Benjamin Schwartz ◽  
Amy K. Olgin ◽  
Judith P. Klinman
Keyword(s):  
Amine Oxidase ◽  
Copper Amine Oxidase ◽  
Topa Quinone ◽  
Copper Amine

scholarly journals The Role of Protein Crystallography in Defining the Mechanisms of Biogenesis and Catalysis in Copper Amine Oxidase

2012 ◽  
Vol 13 (5) ◽  
pp. 5375-5405 ◽  
Author(s):  
Valerie J. Klema ◽  
Carrie M. Wilmot
Keyword(s):  
Amine Oxidase ◽  
Protein Crystallography ◽  
Copper Amine Oxidase ◽  
Copper Amine

Kinetic and Structural Studies on the Catalytic Role of the Aspartic Acid Residue Conserved in Copper Amine Oxidase†,‡

Biochemistry ◽  
2006 ◽  
Vol 45 (13) ◽  
pp. 4105-4120 ◽  
Author(s):  
Yen-Chen Chiu ◽  
Toshihide Okajima ◽  
Takeshi Murakawa ◽  
Mayumi Uchida ◽  
Masayasu Taki ◽  
...  
Keyword(s):  
Aspartic Acid ◽  
Amine Oxidase ◽  
Structural Studies ◽  
Copper Amine Oxidase ◽  
Aspartic Acid Residue ◽  
Catalytic Role ◽  
Copper Amine

Role of a Strictly Conserved Active Site Tyrosine in Cofactor Genesis in the Copper Amine Oxidase fromHansenula polymorpha†

Biochemistry ◽  
2006 ◽  
Vol 45 (10) ◽  
pp. 3178-3188 ◽  
Author(s):  
Jennifer L. DuBois ◽  
Judith P. Klinman
Keyword(s):  
Active Site ◽  
Amine Oxidase ◽  
Copper Amine Oxidase ◽  
Active Site Tyrosine ◽  
Copper Amine

scholarly journals The Copper Amine Oxidase AtCuAOδ Participates in Abscisic Acid-Induced Stomatal Closure in Arabidopsis

Plants ◽  
2019 ◽  
Vol 8 (6) ◽  
pp. 183 ◽  
Author(s):  
Ilaria Fraudentali ◽  
Sandip A. Ghuge ◽  
Andrea Carucci ◽  
Paraskevi Tavladoraki ◽  
Riccardo Angelini ◽  
...  
Keyword(s):  
Abscisic Acid ◽  
Amine Oxidase ◽  
Stomatal Closure ◽  
H2o2 Production ◽  
Amine Oxidases ◽  
Wild Type ◽  
Copper Amine Oxidase ◽  
Copper Amine Oxidases ◽  
Copper Amine

Plant copper amine oxidases (CuAOs) are involved in wound healing, defense against pathogens, methyl-jasmonate-induced protoxylem differentiation, and abscisic acid (ABA)-induced stomatal closure. In the present study, we investigated the role of the Arabidopsis thaliana CuAOδ (AtCuAOδ; At4g12290) in the ABA-mediated stomatal closure by genetic and pharmacological approaches. Obtained data show that AtCuAOδ is up-regulated by ABA and that two Atcuaoδ T-DNA insertional mutants are less responsive to this hormone, showing reduced ABA-mediated stomatal closure and H2O2 accumulation in guard cells as compared to the wild-type (WT) plants. Furthermore, CuAO inhibitors, as well as the hydrogen peroxide (H2O2) scavenger N,N1-dimethylthiourea, reversed most of the ABA-induced stomatal closure in WT plants. Consistently, AtCuAOδ over-expressing transgenic plants display a constitutively increased stomatal closure and increased H2O2 production compared to WT plants. Our data suggest that AtCuAOδ is involved in the H2O2 production related to ABA-induced stomatal closure.

scholarly journals Molecular Mechanism of Topa Quinone Biogenesis in Copper Amine Oxidase.

1997 ◽  
Vol 35 (8) ◽  
pp. 569-575
Author(s):  
Katsuyuki TANIZAWA
Keyword(s):  
Molecular Mechanism ◽  
Amine Oxidase ◽  
Copper Amine Oxidase ◽  
Topa Quinone ◽  
Copper Amine

Role of Copper Ion in Bacterial Copper Amine Oxidase:  Spectroscopic and Crystallographic Studies of Metal-Substituted Enzymes

2003 ◽  
Vol 125 (4) ◽  
pp. 1041-1055 ◽  
Author(s):  
Sei'ichiro Kishishita ◽  
Toshihide Okajima ◽  
Misa Kim ◽  
Hiroshi Yamaguchi ◽  
Shun Hirota ◽  
...  
Keyword(s):  
Amine Oxidase ◽  
Copper Ion ◽  
Copper Amine Oxidase ◽  
Copper Amine

Unprecedented Copper(II) Complex with a Topoquinone-like Moiety as a Structural and Functional Mimic for Copper Amine Oxidase: Role of Copper(II) in the Genesis and Amine Oxidase Activity

ACS Catalysis ◽  
2019 ◽  
Vol 9 (12) ◽  
pp. 10940-10950 ◽  
Author(s):  
Ritambhara Jangir ◽  
Mursaleem Ansari ◽  
Dhananjayan Kaleeswaran ◽  
Gopalan Rajaraman ◽  
Mallayan Palaniandavar ◽  
...  
Keyword(s):  
Oxidase Activity ◽  
Amine Oxidase ◽  
Copper Amine Oxidase ◽  
Amine Oxidase Activity ◽  
Copper Amine

The Nature of O2Reactivity Leading to Topa Quinone in the Copper Amine Oxidase fromHansenula polymorphaand Its Relationship to Catalytic Turnover†

Biochemistry ◽  
2005 ◽  
Vol 44 (34) ◽  
pp. 11381-11388 ◽  
Author(s):  
Jennifer L. DuBois ◽  
Judith P. Klinman
Keyword(s):  
Amine Oxidase ◽  
Copper Amine Oxidase ◽  
Topa Quinone ◽  
Copper Amine

scholarly journals Chemical Rescue of a Site-Specific Mutant of Bacterial Copper Amine Oxidase for Generation of the Topa Quinone Cofactor

Biochemistry ◽  
2004 ◽  
Vol 43 (20) ◽  
pp. 6360-6360
Author(s):  
Hideyuki Matsunami ◽  
Toshihide Okajima ◽  
Shun Hirota ◽  
Hiroshi Yamaguchi ◽  
Hiroshi Hori ◽  
...  
Keyword(s):  
Amine Oxidase ◽  
Copper Amine Oxidase ◽  
Site Specific ◽  
Chemical Rescue ◽  
Topa Quinone ◽  
A Site ◽  
Copper Amine
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