The Primary Specificity of α-Chymotrypsin. Interaction with Acylated Derivatives of D-Valine Methyl Ester and D-Norvaline Methyl Ester*

Abstract We describe the possibilities of formation and preparation of the “natural” 1,3-benzodioxolecarboxylic acids 1, 2, 4, 6 b, and 7, already mentioned in literature. Myristic acid (3e) was prepared in good yield from 3-methoxy-4,5-dihydroxy-benzoic acid ester (3c) , which could be easily made from 3-methoxy-2,3-carbonyldioxy-benzoic acid methylester (3b). Myristicic acid methylester (3d) could be subjected to methylation and hydrolysis leading to 3e without any difficulties. 4.6-dimethoxy-1,3-benzodioxole-5-carboxylic acid (5b) was prepared in good yields by oxidation of 4,6-dimethoxy-1,3-benzodioxole-5-aldehyde (5a). 5.7-dimethoxy-1,3-benzodioxole-carboxylic acid (13f), one of the “unnatural” 1,3-benzodioxolecarboxylic acids, derivatives of o-ipiperonylic acid (8), was prepared from 5-amino-7-methoxy-1,3- benzodioxole-4carboxylic acid methyl ester (13b) by diazotisation, elimination of nitrogen, methylation, and hydrolysis. A comparison of our measured pkA-values showed the strongest acidity belonging to 5,6-dimethoxy-1,3-benzodioxole-4-carbocylic acid (11).

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Synthesis and biological evaluation of new 1,3-thiazolidine-4-one derivatives of nitro-l-arginine methyl ester

Chemistry Central Journal ◽

10.1186/s13065-016-0151-6 ◽

2016 ◽

Vol 10 (1) ◽

Cited By ~ 8

Author(s):

Andreea-Teodora Pânzariu ◽

Maria Apotrosoaei ◽

Ioana Mirela Vasincu ◽

Maria Drăgan ◽

Sandra Constantin ◽

...

Keyword(s):

Methyl Ester ◽

Biological Evaluation ◽

Synthesis And Biological Evaluation ◽

Derivatives Of

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Cationic derivatives of the plant resistance inducer benzo[1,2,3]thiadiazole-7-carbothioic acid S-methyl ester (BTH) as bifunctional ionic liquids

Tetrahedron Letters ◽

10.1016/j.tetlet.2014.04.108 ◽

2014 ◽

Vol 55 (25) ◽

pp. 3565-3568 ◽

Cited By ~ 21

Author(s):

Marcin Smiglak ◽

Rafał Kukawka ◽

Piotr Lewandowski ◽

Henryk Pospieszny

Keyword(s):

Ionic Liquids ◽

Methyl Ester ◽

Plant Resistance ◽

Derivatives Of

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Proton magnetic resonance and mass spectrometric studies on derivatives of sodium 2-O-α-D-mannopyranosyl-D-glycerate and related compounds

Canadian Journal of Chemistry ◽

10.1139/v69-676 ◽

1969 ◽

Vol 47 (21) ◽

pp. 4083-4086 ◽

Cited By ~ 7

Author(s):

J. N. C. Whyte

Keyword(s):

Magnetic Resonance ◽

Methyl Ester ◽

Proton Magnetic Resonance ◽

Mass Spectra ◽

Red Alga ◽

Mass Spectrometric ◽

Derivatives Of ◽

Related Compounds

The proton magnetic resonance (p.m.r.) and mass spectra of the methyl ester pentaacetate of sodium 2-O-α-D-mannopyranosyl-D-glycerate from the red alga Rhodomela larix are compared to those of related compounds to affirm the assigned structure.

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