Biochemical and Structural Studies with Prenyl Diphosphate Analogues Provide Insights into Isoprenoid Recognition by Protein Farnesyl Transferase†,‡

Biochemistry ◽  
2003 ◽  
Vol 42 (13) ◽  
pp. 3716-3724 ◽  
Author(s):  
Tammy C. Turek-Etienne ◽  
Corey L. Strickland ◽  
Mark D. Distefano
Keyword(s):  
Structural Studies ◽  
Farnesyl Transferase ◽  
Protein Farnesyl Transferase ◽  
Prenyl Diphosphate

Evaluation of Isoprenoid Conformation in Solution and in the Active Site of Protein-Farnesyl Transferase Using Carbon-13 Labeling in Conjunction with Solution- and Solid-State NMR

2000 ◽  
Vol 122 (30) ◽  
pp. 7153-7164 ◽  
Author(s):  
Todd J. Zahn ◽  
Markus Eilers ◽  
Zhengmao Guo ◽  
Mohamad B. Ksebati ◽  
Matthew Simon ◽  
...  
Keyword(s):  
Solid State ◽  
Active Site ◽  
Solid State Nmr ◽  
Farnesyl Transferase ◽  
Protein Farnesyl Transferase

Heteronemin as a Protein Farnesyl Transferase Inhibitor

2004 ◽  
Vol 42 (6) ◽  
pp. 454-456 ◽  
Author(s):  
Véronique Ledroit ◽  
Cécile Debitus ◽  
Frédéric Ausseil ◽  
Roselyne Raux ◽  
Jean-Louis Menou ◽  
...  
Keyword(s):  
Farnesyl Transferase ◽  
Protein Farnesyl Transferase ◽  
Farnesyl Transferase Inhibitor

A Protein Farnesyl Transferase Involved in Abscisic Acid Signal Transduction in Arabidopsis

Science ◽  
1996 ◽  
Vol 273 (5279) ◽  
pp. 1239-1241 ◽  
Author(s):  
S. Cutler ◽  
M. Ghassemian ◽  
D. Bonetta ◽  
S. Cooney ◽  
P. McCourt
Keyword(s):  
Signal Transduction ◽  
Abscisic Acid ◽  
Farnesyl Transferase ◽  
Protein Farnesyl Transferase

Protein Farnesyl Transferase Target Selectivity Is Dependent upon Peptide Stimulated Product Release†

Biochemistry ◽  
2007 ◽  
Vol 46 (40) ◽  
pp. 11299-11309 ◽  
Author(s):  
Jerry M. Troutman ◽  
Douglas A. Andres ◽  
H. Peter Spielmann
Keyword(s):  
Farnesyl Transferase ◽  
Product Release ◽  
Protein Farnesyl Transferase

3.P.242 Farnesyl pyrophosphate analogue, an inhibitor of protein: Farnesyl transferase in vitro, inhibits human smooth muscle cell proliferation in culture

1997 ◽  
Vol 134 (1-2) ◽  
pp. 249
Author(s):  
L.H. Cohen ◽  
E. Pieterman ◽  
R.E.W. van Leeuwen ◽  
P. Negre-Aminou ◽  
A.R.P.M. Valentijn ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Smooth Muscle Cell Proliferation ◽  
Farnesyl Pyrophosphate ◽  
Farnesyl Transferase ◽  
Protein Farnesyl Transferase ◽  
Human Smooth Muscle Cell

Selective Modification of CaaX Peptides withortho-Substituted Anilinogeranyl Lipids by Protein Farnesyl Transferase:  Competitive Substrates and Potent Inhibitors from a Library of Farnesyl Diphosphate Analogues†

Biochemistry ◽  
2007 ◽  
Vol 46 (40) ◽  
pp. 11310-11321 ◽  
Author(s):  
Jerry M. Troutman ◽  
Thangaiah Subramanian ◽  
Douglas A. Andres ◽  
H. Peter Spielmann
Keyword(s):  
Farnesyl Diphosphate ◽  
Farnesyl Transferase ◽  
Protein Farnesyl Transferase

Inhibition of RAS-targeted prenylation: protein farnesyl transferase inhibitors revisited

2000 ◽  
Vol 33 (1) ◽  
pp. 7-23 ◽  
Author(s):  
Bridget T Hill ◽  
Dominique Perrin ◽  
Anna Kruczynski
Keyword(s):  
Farnesyl Transferase ◽  
Protein Farnesyl Transferase ◽  
Farnesyl Transferase Inhibitors

Meroterpenes fromDichrostachys cinereaInhibit Protein Farnesyl Transferase Activity

2009 ◽  
Vol 72 (10) ◽  
pp. 1804-1815 ◽  
Author(s):  
Christophe Long ◽  
Laurence Marcourt ◽  
Roselyne Raux ◽  
Bruno David ◽  
Christelle Gau ◽  
...  
Keyword(s):  
Transferase Activity ◽  
Farnesyl Transferase ◽  
Protein Farnesyl Transferase

Synthesis of acyloxymethyl ester prodrugs of the transferable protein farnesyl transferase substrate farnesyl methylenediphosphonate

2004 ◽  
Vol 14 (19) ◽  
pp. 4979-4982 ◽  
Author(s):  
Jerry M. Troutman ◽  
Kareem A.H. Chehade ◽  
Katarzyna Kiegiel ◽  
Douglas A. Andres ◽  
H. Peter Spielmann
Keyword(s):  
Farnesyl Transferase ◽  
Protein Farnesyl Transferase ◽  
Ester Prodrugs
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