Structural Basis for Thermal Stability of Human Low-Density Lipoprotein†

Biochemistry ◽  
2005 ◽  
Vol 44 (10) ◽  
pp. 3965-3971 ◽  
Author(s):  
Shobini Jayaraman ◽  
Donald Gantz ◽  
Olga Gursky
Keyword(s):  
Thermal Stability ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Structural Basis ◽  
Low Density ◽  
Thermal Stability Of

Thermal Stability of Apolipoprotein B100 in Low-Density Lipoprotein Is Disrupted at Early Stages of Oxidation While Neutral Lipid Core Organization Is Conserved†

Biochemistry ◽  
1998 ◽  
Vol 37 (3) ◽  
pp. 938-944 ◽  
Author(s):  
Ruth Prassl ◽  
Bernhard Schuster ◽  
Peter Laggner ◽  
Claudie Flamant ◽  
Fabienne Nigon ◽  
...  
Keyword(s):  
Thermal Stability ◽  
Neutral Lipid ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
Lipid Core ◽  
Early Stages ◽  
Apolipoprotein B100 ◽  
Thermal Stability Of

scholarly journals Thermal stability of human plasma electronegative low-density lipoprotein: A paradoxical behavior of low-density lipoprotein aggregation

2016 ◽  
Vol 1861 (9) ◽  
pp. 1015-1024 ◽  
Author(s):  
Anna Rull ◽  
Shobini Jayaraman ◽  
Donald L. Gantz ◽  
Andrea Rivas-Urbina ◽  
Montserrat Pérez-Cuellar ◽  
...  
Keyword(s):  
Thermal Stability ◽  
Human Plasma ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
Lipoprotein A ◽  
Lipoprotein Aggregation ◽  
Thermal Stability Of

Intralysosomal Accumulation of Colloidal Gold-Low Density Lipoprotein Conjugates in Chloroquine-Treated Fibroblasts

1985 ◽  
Vol 43 ◽  
pp. 546-547 ◽  
Author(s):  
Dean A. Handley ◽  
Cynthia M. Arbeeny ◽  
Larry D. Witte
Keyword(s):  
Colloidal Gold ◽  
Cultured Cells ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Coated Vesicle ◽  
Low Density ◽  
Cholesterol Esters ◽  
Cultured Fibroblasts ◽  
Surface Receptors ◽  
Ldl Particles

Low density lipoproteins (LDL) are the major cholesterol carrying particles in the blood. Using cultured cells, it has been shown that LDL particles interact with specific surface receptors and are internalized via a coated pit-coated vesicle pathway for lysosomal catabolism. This (Pathway has been visualized using LDL labeled to ferritin or colloidal gold. It is now recognized that certain lysomotropic agents, such as chloroquine, inhibit lysosomal enzymes that degrade protein and cholesterol esters. By interrupting cholesterol ester hydrolysis, chloroquine treatment results in lysosomal accumulation of cholesterol esters from internalized LDL. Using LDL conjugated to colloidal gold, we have examined the ultrastructural effects of chloroquine on lipoprotein uptake by normal cultured fibroblasts.

Involvement of beta2-glycoprotein I and anticardiolipin antibodies in oxidatively modified low-density lipoprotein uptake by macrophages

1997 ◽  
Vol 107 (3) ◽  
pp. 569-573 ◽  
Author(s):  
Y. HASUNUMA ◽  
E. MATSUURA ◽  
Z. MAKITA ◽  
T. KATAHIRA ◽  
S. NISHI ◽  
...  
Keyword(s):  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Anticardiolipin Antibodies ◽  
Low Density ◽  
Glycoprotein I ◽  
Lipoprotein Uptake ◽  
Oxidatively Modified
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