The Role of Gβγ and Domain Interfaces in the Activation of G Protein-Coupled Receptor Kinase 2†

Biochemistry ◽  
2005 ◽  
Vol 44 (18) ◽  
pp. 6958-6970 ◽  
Author(s):  
David T. Lodowski ◽  
Jennifer F. Barnhill ◽  
Robyn M. Pyskadlo ◽  
Rodolfo Ghirlando ◽  
Rachel Sterne-Marr ◽  
...  
Keyword(s):  
G Protein ◽  
Receptor Kinase ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled

Chapter 16. The Complex Role of G Protein-coupled Receptor Kinase 2 (GRK2) in Cell Signalling: Beyond GPCR Desensitization

2011 ◽  
pp. 316-334
Author(s):  
Federico Mayor Jr. ◽  
Petronila Penela ◽  
Catalina Ribas ◽  
Cristina Murga
Keyword(s):  
G Protein ◽  
Cell Signalling ◽  
Receptor Kinase ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled ◽  
Gpcr Desensitization

scholarly journals Role of G protein-coupled receptor kinase 2 in tumoral angiogenesis

2014 ◽  
Vol 1 (4) ◽  
pp. e969166 ◽  
Author(s):  
Verónica Rivas ◽  
Laura Nogués ◽  
Clara Reglero ◽  
Federico Mayor ◽  
Petronila Penela
Keyword(s):  
G Protein ◽  
Receptor Kinase ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled

scholarly journals Regulation of cellular oxidative stress and apoptosis by G protein-coupled receptor kinase-2; The role of NADPH oxidase 4

2016 ◽  
Vol 28 (3) ◽  
pp. 190-203 ◽  
Author(s):  
Tiju Theccanat ◽  
Jennifer L. Philip ◽  
Abdur M. Razzaque ◽  
Nicholas Ludmer ◽  
Jinju Li ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Nadph Oxidase ◽  
G Protein ◽  
Receptor Kinase ◽  
G Protein Coupled Receptor ◽  
Nadph Oxidase 4 ◽  
G Protein Coupled

scholarly journals Important role of G protein-coupled receptor kinase 5 in homologous desensitization of the thyrotropin receptor.

1996 ◽  
Vol 71 ◽  
pp. 71
Author(s):  
Yuji Nagayama ◽  
Kunihiko Tanaka ◽  
Kohtaro Taniyama ◽  
Masami Niwa
Keyword(s):  
G Protein ◽  
Thyrotropin Receptor ◽  
Receptor Kinase ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled ◽  
Homologous Desensitization

scholarly journals THE ROLE OF G PROTEIN-COUPLED RECEPTOR KINASE 4 IN CARDIOMYOCYTE INJURY AFTER MYOCARDIAL INFARCTION

2019 ◽  
Vol 37 ◽  
pp. e84
Author(s):  
L. Li ◽  
L. Tang ◽  
S. Qu ◽  
D. Yang ◽  
Q. Liao ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
G Protein ◽  
Receptor Kinase ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled

scholarly journals Role of Endothelial G Protein-Coupled Receptor Kinase 2 in Angioedema

Hypertension ◽  
2020 ◽  
Vol 76 (5) ◽  
pp. 1625-1636 ◽  
Author(s):  
Jessica Gambardella ◽  
Daniela Sorriento ◽  
Maria Bova ◽  
Mariarosaria Rusciano ◽  
Stefania Loffredo ◽  
...  
Keyword(s):  
Vascular Permeability ◽  
G Protein ◽  
Molecular Mechanisms ◽  
No Production ◽  
Receptor Kinase ◽  
Severe Phenotype ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled

Excessive BK (bradykinin) stimulation is responsible for the exaggerated permeabilization of the endothelium in angioedema. However, the molecular mechanisms underlying these responses have not been investigated. BK receptors are Gq-protein-coupled receptors phosphorylated by GRK2 (G protein-coupled receptor kinase 2) with a hitherto unknown biological and pathophysiological significance. In the present study, we sought to identify the functional role of GRK2 in angioedema through the regulation of BK signaling. We found that the accumulation of cytosolic Ca 2+ in endothelial cells induced by BK was sensitive to GRK2 activity, as it was significantly augmented by inhibiting the kinase. Accordingly, permeabilization and NO production induced by BK were enhanced, as well. In vivo, mice with reduced GRK2 levels in the endothelium (Tie2-CRE/GRK2 fl+/fl − ) exhibited an increased response to BK in terms of vascular permeability and extravasation. Finally, patients with reduced GRK2 levels displayed a severe phenotype of angioedema. Taken together, these findings establish GRK2 as a novel pivotal regulator of BK signaling with an essential role in the pathophysiology of vascular permeability and angioedema.

scholarly journals Role of G‐protein coupled receptor kinase‐2 (GRK2) in the modulation of renal vascular response in SHR by PPAR

2008 ◽  
Vol 22 (S1) ◽  
Author(s):  
Zivar Yousefipour ◽  
Adebayo Oyekan ◽  
Mohammad Newaz
Keyword(s):  
G Protein ◽  
Receptor Kinase ◽  
Vascular Response ◽  
G Protein Coupled Receptor ◽  
Renal Vascular ◽  
G Protein Coupled

scholarly journals Role of the Amino Terminus of G Protein-Coupled Receptor Kinase 2 in Receptor Phosphorylation

Biochemistry ◽  
2009 ◽  
Vol 48 (30) ◽  
pp. 7325-7333 ◽  
Author(s):  
Christina S. Pao ◽  
Breann L. Barker ◽  
Jeffrey L. Benovic
Keyword(s):  
G Protein ◽  
Amino Terminus ◽  
Receptor Kinase ◽  
G Protein Coupled Receptor ◽  
Receptor Phosphorylation ◽  
G Protein Coupled

A novel role of G protein-coupled receptor kinase 5 in urotensin II-stimulated cellular hypertrophy in H9c2UT cells

2016 ◽  
Vol 422 (1-2) ◽  
pp. 151-160 ◽  
Author(s):  
Cheon Ho Park ◽  
Ju Hee Lee ◽  
Mi Young Lee ◽  
Jeong Hyun Lee ◽  
Byung Ho Lee ◽  
...  
Keyword(s):  
G Protein ◽  
Receptor Kinase ◽  
Urotensin Ii ◽  
G Protein Coupled Receptor ◽  
Cellular Hypertrophy ◽  
G Protein Coupled
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