scholarly journals Role of the Amino Terminus of G Protein-Coupled Receptor Kinase 2 in Receptor Phosphorylation

Biochemistry ◽  
2009 ◽  
Vol 48 (30) ◽  
pp. 7325-7333 ◽  
Author(s):  
Christina S. Pao ◽  
Breann L. Barker ◽  
Jeffrey L. Benovic
Keyword(s):  
G Protein ◽  
Amino Terminus ◽  
Receptor Kinase ◽  
G Protein Coupled Receptor ◽  
Receptor Phosphorylation ◽  
G Protein Coupled

Chapter 16. The Complex Role of G Protein-coupled Receptor Kinase 2 (GRK2) in Cell Signalling: Beyond GPCR Desensitization

2011 ◽  
pp. 316-334
Author(s):  
Federico Mayor Jr. ◽  
Petronila Penela ◽  
Catalina Ribas ◽  
Cristina Murga
Keyword(s):  
G Protein ◽  
Cell Signalling ◽  
Receptor Kinase ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled ◽  
Gpcr Desensitization

scholarly journals RGS domain in the amino terminus of G protein-coupled receptor kinase 2 inhibits Gq-mediated signaling

2000 ◽  
Vol 82 ◽  
pp. 54
Author(s):  
Hirokazu Usui ◽  
Mariko Nishiyama ◽  
Kayoko Moroi ◽  
Tadao Shibasaki ◽  
Jing Zhou ◽  
...  
Keyword(s):  
G Protein ◽  
Amino Terminus ◽  
Receptor Kinase ◽  
G Protein Coupled Receptor ◽  
Rgs Domain ◽  
G Protein Coupled

G protein‐coupled receptor kinase 2 can enhance beta‐arrestin recruitment to the D 2 dopamine receptor in the absence of receptor phosphorylation

2020 ◽  
Vol 34 (S1) ◽  
pp. 1-1
Author(s):  
Marta Sanchez-Soto ◽  
Kayla A. Schardien ◽  
Laura Inbody ◽  
R. Benjamin Free ◽  
David R. Sibley
Keyword(s):  
Dopamine Receptor ◽  
G Protein ◽  
Receptor Kinase ◽  
G Protein Coupled Receptor ◽  
Receptor Phosphorylation ◽  
G Protein Coupled

scholarly journals Role of G protein-coupled receptor kinase 2 in tumoral angiogenesis

2014 ◽  
Vol 1 (4) ◽  
pp. e969166 ◽  
Author(s):  
Verónica Rivas ◽  
Laura Nogués ◽  
Clara Reglero ◽  
Federico Mayor ◽  
Petronila Penela
Keyword(s):  
G Protein ◽  
Receptor Kinase ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled

scholarly journals Regulation of cellular oxidative stress and apoptosis by G protein-coupled receptor kinase-2; The role of NADPH oxidase 4

2016 ◽  
Vol 28 (3) ◽  
pp. 190-203 ◽  
Author(s):  
Tiju Theccanat ◽  
Jennifer L. Philip ◽  
Abdur M. Razzaque ◽  
Nicholas Ludmer ◽  
Jinju Li ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Nadph Oxidase ◽  
G Protein ◽  
Receptor Kinase ◽  
G Protein Coupled Receptor ◽  
Nadph Oxidase 4 ◽  
G Protein Coupled

scholarly journals G Protein-coupled Receptor Kinase-2 Constitutively Regulates D2Dopamine Receptor Expression and Signaling Independently of Receptor Phosphorylation

2009 ◽  
Vol 284 (49) ◽  
pp. 34103-34115 ◽  
Author(s):  
Yoon Namkung ◽  
Concetta Dipace ◽  
Eneko Urizar ◽  
Jonathan A. Javitch ◽  
David R. Sibley
Keyword(s):  
G Protein ◽  
Receptor Expression ◽  
Receptor Kinase ◽  
G Protein Coupled Receptor ◽  
Receptor Phosphorylation ◽  
G Protein Coupled

scholarly journals Important role of G protein-coupled receptor kinase 5 in homologous desensitization of the thyrotropin receptor.

1996 ◽  
Vol 71 ◽  
pp. 71
Author(s):  
Yuji Nagayama ◽  
Kunihiko Tanaka ◽  
Kohtaro Taniyama ◽  
Masami Niwa
Keyword(s):  
G Protein ◽  
Thyrotropin Receptor ◽  
Receptor Kinase ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled ◽  
Homologous Desensitization

Identification of G Protein-Coupled Receptor Kinase 2 Phosphorylation Sites Responsible for Agonist-Stimulated δ-Opioid Receptor Phosphorylation

2000 ◽  
Vol 58 (5) ◽  
pp. 1050-1056 ◽  
Author(s):  
Jun Guo ◽  
Yalan Wu ◽  
Wenbo Zhang ◽  
Jing Zhao ◽  
Lakshmi A. Devi ◽  
...  
Keyword(s):  
G Protein ◽  
Opioid Receptor ◽  
Phosphorylation Sites ◽  
Receptor Kinase ◽  
G Protein Coupled Receptor ◽  
Receptor Phosphorylation ◽  
Δ Opioid Receptor ◽  
G Protein Coupled

scholarly journals THE ROLE OF G PROTEIN-COUPLED RECEPTOR KINASE 4 IN CARDIOMYOCYTE INJURY AFTER MYOCARDIAL INFARCTION

2019 ◽  
Vol 37 ◽  
pp. e84
Author(s):  
L. Li ◽  
L. Tang ◽  
S. Qu ◽  
D. Yang ◽  
Q. Liao ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
G Protein ◽  
Receptor Kinase ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled

scholarly journals Role of Endothelial G Protein-Coupled Receptor Kinase 2 in Angioedema

Hypertension ◽  
2020 ◽  
Vol 76 (5) ◽  
pp. 1625-1636 ◽  
Author(s):  
Jessica Gambardella ◽  
Daniela Sorriento ◽  
Maria Bova ◽  
Mariarosaria Rusciano ◽  
Stefania Loffredo ◽  
...  
Keyword(s):  
Vascular Permeability ◽  
G Protein ◽  
Molecular Mechanisms ◽  
No Production ◽  
Receptor Kinase ◽  
Severe Phenotype ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled

Excessive BK (bradykinin) stimulation is responsible for the exaggerated permeabilization of the endothelium in angioedema. However, the molecular mechanisms underlying these responses have not been investigated. BK receptors are Gq-protein-coupled receptors phosphorylated by GRK2 (G protein-coupled receptor kinase 2) with a hitherto unknown biological and pathophysiological significance. In the present study, we sought to identify the functional role of GRK2 in angioedema through the regulation of BK signaling. We found that the accumulation of cytosolic Ca 2+ in endothelial cells induced by BK was sensitive to GRK2 activity, as it was significantly augmented by inhibiting the kinase. Accordingly, permeabilization and NO production induced by BK were enhanced, as well. In vivo, mice with reduced GRK2 levels in the endothelium (Tie2-CRE/GRK2 fl+/fl − ) exhibited an increased response to BK in terms of vascular permeability and extravasation. Finally, patients with reduced GRK2 levels displayed a severe phenotype of angioedema. Taken together, these findings establish GRK2 as a novel pivotal regulator of BK signaling with an essential role in the pathophysiology of vascular permeability and angioedema.

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