The Slow-Onset Nature of Allosteric Inhibition in α-Isopropylmalate Synthase from Mycobacterium tuberculosis Is Mediated by a Flexible Loop

Biochemistry ◽  
2012 ◽  
Vol 51 (24) ◽  
pp. 4773-4775 ◽  
Author(s):  
Ashley K. Casey ◽  
Joshua Baugh ◽  
Patrick A. Frantom
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Allosteric Inhibition ◽  
Isopropylmalate Synthase ◽  
Flexible Loop ◽  
Slow Onset

scholarly journals Exploring Covalent Allosteric Inhibition of Antigen 85C from Mycobacterium tuberculosis by Ebselen Derivatives

2017 ◽  
Vol 3 (5) ◽  
pp. 378-387 ◽  
Author(s):  
Christopher M. Goins ◽  
Steven Dajnowicz ◽  
Sandeep Thanna ◽  
Steven J. Sucheck ◽  
Jerry M. Parks ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Allosteric Inhibition

Slow-onset Feedback Inhibition:  Inhibition ofMycobacteriumtuberculosisα-Isopropylmalate Synthase byl-Leucine

2005 ◽  
Vol 127 (28) ◽  
pp. 10004-10005 ◽  
Author(s):  
Luiz P. S. de Carvalho ◽  
Argyrides Argyrou ◽  
John S. Blanchard
Keyword(s):  
Feedback Inhibition ◽  
Isopropylmalate Synthase ◽  
Slow Onset

scholarly journals Identification of inhibitors against α-Isopropylmalate Synthase of Mycobacterium tuberculosis using docking-MM/PBSA hybrid approach

2017 ◽  
Vol 13 (05) ◽  
pp. 144-148 ◽  
Author(s):  
Preeti Pandey ◽  
◽  
Andrew M. Lynn ◽  
Pradipta Bandyopadhyay ◽  
◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Hybrid Approach ◽  
Isopropylmalate Synthase

scholarly journals Structural Insight into Allosteric Inhibition of Mycobacterium tuberculosis Tryptophan Synthase

2017 ◽  
Vol 31 (S1) ◽  
Author(s):  
Karolina Michalska ◽  
Samantha Wellington ◽  
Partha P. Nag ◽  
Robert Jedrzejczak ◽  
Natalia I. Maltseva ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Tryptophan Synthase ◽  
Allosteric Inhibition ◽  
Structural Insight ◽  
Insight Into

scholarly journals Structure of Mycobacterium tuberculosis tryptophan synthase: a model system for allosteric inhibition

2017 ◽  
Vol 73 (a1) ◽  
pp. a288-a288
Author(s):  
Karolina Michalska ◽  
Samantha Wellington ◽  
Partha P. Nag ◽  
Robert Jedrzejczak ◽  
Natalia I. Maltseva ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Model System ◽  
Tryptophan Synthase ◽  
Allosteric Inhibition

scholarly journals Structural insight into allosteric inhibition of Mycobacterium tuberculosis tryptophan synthase

2017 ◽  
Vol 73 (a1) ◽  
pp. a428-a428
Author(s):  
Andrzej Joachimiak ◽  
Samantha Wellington ◽  
Partha P. Nag ◽  
Robert Jedrzejczak ◽  
Natalia I. Maltseva ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Tryptophan Synthase ◽  
Allosteric Inhibition ◽  
Structural Insight ◽  
Insight Into
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