Nanoparticles Produced by Ring-Opening Metathesis Polymerization Using Norbornenyl-poly(ethylene oxide) as a Ligand-Free Generic Platform for Highly Selective In Vivo Tumor Targeting

2013 ◽  
Vol 14 (7) ◽  
pp. 2396-2402 ◽  
Author(s):  
Fabien Gueugnon ◽  
Iza Denis ◽  
Daniel Pouliquen ◽  
Floraine Collette ◽  
Régis Delatouche ◽  
...  
Polymers ◽  
2017 ◽  
Vol 9 (12) ◽  
pp. 145 ◽  
Author(s):  
George Theodosopoulos ◽  
Christos Zisis ◽  
Georgios Charalambidis ◽  
Vasilis Nikolaou ◽  
Athanassios Coutsolelos ◽  
...  

e-Polymers ◽  
2001 ◽  
Vol 1 (1) ◽  
Author(s):  
Yakai Feng ◽  
Doris Klee ◽  
Hartwig Höcker

AbstractFor the purpose of increasing the hydrophilicity of polylactide, new block copolymers with protected functional groups, poly(lactide-co-(S)-b-benzyl aspartate)-poly(ethylene oxide)-poly(lactide-co-(S)- b-benzyl aspartate), were synthesized via ring-opening polymerization of D,L-lactide and (3S, 6R,S)-3- [(benzyloxycarbonyl)methyl]-6-methylmorpholine-2,5-dione in the presence of hydroxyltelechelic poly(ethylene oxide) (PEO) as an initiator at 140 °C for 24 h. The benzyl protective groups of the block copolymers were completely removed to give poly(lactide-co-(S)-aspartic acid)-PEO-poly(lactide-co-(S)-aspartic acid), (poly(DLLA-co-Asp)-b-PEO-b-poly(DLLA-co-Asp)). This shows lower crystallization and melting temperature compared with the polymers before deprotection. Poly(DLLA-co-Asp)-b-PEO-b-poly(DLLA-co-Asp) with 55.6 wt.-% of PEO is more hydrophilic, shows higher water absorption and is degraded faster than with 39.5 wt.-% of PEO.


Clinics ◽  
2012 ◽  
Vol 67 (7) ◽  
pp. 793-798 ◽  
Author(s):  
DC Coraca-Huber ◽  
EAR Duek ◽  
M Etchebehere ◽  
LA Magna ◽  
EMI Amstalden

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