Identification of Neuropeptide S Antagonists: Structure–Activity Relationship Studies, X-ray Crystallography, and in Vivo Evaluation

Activity Relationship ◽

Neuropeptide S ◽

In Vivo Evaluation ◽

X Ray ◽

X Ray Crystallography ◽

Fluoro-benzimidazole derivatives to cure Alzheimer’s disease: In-silico studies, synthesis, structure-activity relationship and in vivo evaluation for β secretase enzyme inhibition

Bioorganic Chemistry ◽

10.1016/j.bioorg.2019.102936 ◽

2019 ◽

Vol 88 ◽

pp. 102936 ◽

Cited By ~ 1

Author(s):

Sayyad Ali ◽

Muhammad Hassham Hassan Bin Asad ◽

Soham Maity ◽

Wahid Zada ◽

Albert A. Rizvanov ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Enzyme Inhibition ◽

In Silico ◽

Activity Relationship ◽

Benzimidazole Derivatives ◽

In Vivo Evaluation ◽

Structure Activity ◽

In Silico Studies

Fungal metabolite ophiobolin A as a promising anti-glioma agent: In vivo evaluation, structure–activity relationship and unique pyrrolylation of primary amines

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2015.08.066 ◽

2015 ◽

Vol 25 (20) ◽

pp. 4544-4548 ◽

Cited By ~ 19

Author(s):

Ramesh Dasari ◽

Marco Masi ◽

Romana Lisy ◽

Marlène Ferdérin ◽

Lance R. English ◽

...

Keyword(s):

Activity Relationship ◽

Primary Amines ◽

Fungal Metabolite ◽

In Vivo Evaluation ◽

Probing the Subpockets of Factor Xa Reveals Two Binding Modes for Inhibitors Based on a 2-Carboxyindole Scaffold: A Study Combining Structure-Activity Relationship and X-ray Crystallography

10.1021/jm0490540 ◽

2005 ◽

Vol 48 (14) ◽

pp. 4511-4525 ◽

Cited By ~ 77

Author(s):

Marc Nazaré ◽

David W. Will ◽

Hans Matter ◽

Herman Schreuder ◽

Kurt Ritter ◽

...

Keyword(s):

Factor Xa ◽

Activity Relationship ◽

Binding Modes ◽

X Ray ◽

X Ray Crystallography ◽

Structure–Activity Relationship and in Vitro and in Vivo Evaluation of the Potent Cytotoxic Anti-microtubule AgentN-(4-Methoxyphenyl)-N,2,6-trimethyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-aminium Chloride and Its Analogues As Antitumor Agents

10.1021/jm400639z ◽

2013 ◽

Vol 56 (17) ◽

pp. 6829-6844 ◽

Cited By ~ 18

Author(s):

Aleem Gangjee ◽

Ying Zhao ◽

Sudhir Raghavan ◽

Cristina C. Rohena ◽

Susan L. Mooberry ◽

...

Keyword(s):

Antitumor Agents ◽

Activity Relationship ◽

In Vivo Evaluation ◽

Fluorinated Diaryl Sulfides as Serotonin Transporter Ligands: Synthesis, Structure−Activity Relationship Study, and in Vivo Evaluation of Fluorine-18-Labeled Compounds as PET Imaging Agents

10.1021/jm0400808 ◽

2005 ◽

Vol 48 (7) ◽

pp. 2559-2570 ◽

Cited By ~ 45

Author(s):

Yiyun Huang ◽

Sung-A Bae ◽

Zhihong Zhu ◽

Ningning Guo ◽

Bryan L. Roth ◽

...

Keyword(s):

Serotonin Transporter ◽

Pet Imaging ◽

Activity Relationship ◽

Imaging Agents ◽

Labeled Compounds ◽

In Vivo Evaluation ◽

Structure Activity ◽

Relationship Study

Structure–Activity Relationship Studies on Oxazolo[3,4-a]pyrazine Derivatives Leading to the Discovery of a Novel Neuropeptide S Receptor Antagonist with Potent In Vivo Activity

10.1021/acs.jmedchem.0c02223 ◽

2021 ◽

Author(s):

Valentina Albanese ◽

Chiara Ruzza ◽

Erika Marzola ◽

Tatiana Bernardi ◽

Martina Fabbri ◽

...

Keyword(s):

Receptor Antagonist ◽

Activity Relationship ◽

Neuropeptide S ◽

Novel pyrazolo[4,3-d]pyrimidine microtubule targeting agents (MTAs): Synthesis, structure–activity relationship, in vitro and in vivo evaluation as antitumor agents

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2021.127923 ◽

2021 ◽

Vol 41 ◽

pp. 127923

Author(s):

Farhana Islam ◽

Tasdique M. Quadery ◽

Ruoli Bai ◽

Lerin R. Luckett-Chastain ◽

Ernest Hamel ◽

...

Keyword(s):

Antitumor Agents ◽

Activity Relationship ◽

In Vivo Evaluation ◽

Structure Activity ◽

Microtubule Targeting Agents

Synthesis of new generation triazolyl- and isoxazolyl-containing 6-nitro-2,3-dihydroimidazooxazoles as anti-TB agents: in vitro, structure–activity relationship, pharmacokinetics and in vivo evaluation

Organic & Biomolecular Chemistry ◽

10.1039/c5ob00054h ◽

2015 ◽

Vol 13 (12) ◽

pp. 3610-3624 ◽

Cited By ~ 14

Author(s):

Gurunadham Munagala ◽

Kushalava Reddy Yempalla ◽

Samsher Singh ◽

Sumit Sharma ◽

Nitin Pal Kalia ◽

...

Keyword(s):

Activity Relationship ◽

In Vivo Evaluation ◽

Structure Activity ◽

New Generation

Promising nitroimidazoloxazole scaffold gives another novel triazolyl-containing 6-nitro-2,3-dihydroimidazooxazole as anti-TB lead.

Exploring 3-hydroxyflavone scaffolds as mushroom tyrosinase inhibitors: synthesis, X-ray crystallography, antimicrobial, fluorescence behaviour, structure-activity relationship and molecular modelling studies

Journal of Biomolecular Structure and Dynamics ◽

10.1080/07391102.2020.1805364 ◽

2020 ◽

pp. 1-16

Author(s):

Jamshaid Ashraf ◽

Ehsan Ullah Mughal ◽

Amina Sadiq ◽

Maryam Bibi ◽

Nafeesa Naeem ◽

...

Keyword(s):

Molecular Modelling ◽

Activity Relationship ◽

Mushroom Tyrosinase ◽

X Ray ◽

X Ray Crystallography ◽

Structure Activity ◽

Molecular Modelling Studies ◽

Modelling Studies ◽

Tyrosinase Inhibitors

Antimalarial benzoheterocyclic 4-aminoquinolines: Structure–activity relationship, in vivo evaluation, mechanistic and bioactivation studies

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2015.07.051 ◽

2015 ◽

Vol 23 (17) ◽

pp. 5419-5432 ◽

Cited By ~ 11

Author(s):

Dennis S.B. Ongarora ◽

Natasha Strydom ◽

Kathryn Wicht ◽

Mathew Njoroge ◽

Lubbe Wiesner ◽

...

Keyword(s):

Activity Relationship ◽

In Vivo Evaluation ◽