Modeling Ion Channels Using Poisson–Nernst–Planck Theory as an Integrated Approach To Introducing Nanotechnology Concepts: The PNP Cyclic Peptide Ion Channel Model

2008 ◽  
Vol 85 (5) ◽  
pp. 744 ◽  
Author(s):  
Brian Radak ◽  
Hyonseok Hwang ◽  
George C. Schatz
Keyword(s):  
Ion Channels ◽  
Ion Channel ◽  
Channel Model ◽  
Cyclic Peptide ◽  
Integrated Approach ◽  
Ion Channel Model

scholarly journals A New Neuron Ion Channel Model with Noisy Input Current

2015 ◽  
Vol 2 (1) ◽  
Author(s):  
Ahmed Mahmood Khudhur ◽  
Ahmed N Abdalla
Keyword(s):  
Ion Channels ◽  
Ion Channel ◽  
Channel Model ◽  
Fundamental Problem ◽  
Input Current ◽  
Estimation Methods ◽  
Channel Noise ◽  
Single Individual ◽  
Noisy Input ◽  
Ion Channel Model

The data processing fundamental problem affects all aspects of nervous-system function by the noise of ion channels. The conducting and non conducting of ion channels depends on random transitions of channel noise, which affect the states of several numbers of gates in every single individual ion channel. This paper, introduce a new ion channel model in the neuron with noisy input current as approximations of the HH model. It briefly introduces the ion channel based on stochastic Hodgkin-Huxley model. The method is able to fully constrain the HH model and obtain all models capable of reproducing the data. Therefore, this method overcomes the limitations of other parameter estimation methods. The stochastic Markov process method is simply applied to simulate each gate individually to determine the relationship between channel noise and the spike frequency.

scholarly journals A New Neuron Ion Channel Model Under Time Varying Input Currents

2021 ◽  
Vol 1999 (1) ◽  
pp. 012127
Author(s):  
Ahmed Mahmood Khudhur ◽  
Ahmed M Shano ◽  
Abdul Salam Hassan Abbas
Keyword(s):  
Ion Channel ◽  
Channel Model ◽  
Time Varying ◽  
Ion Channel Model

scholarly journals Image Charge Method for Reaction Fields in a Hybrid Ion-Channel Model

2011 ◽  
Vol 9 (4) ◽  
pp. 1056-1070 ◽  
Author(s):  
Zhenli Xu ◽  
Wei Cai ◽  
Xiaolin Cheng
Keyword(s):  
Boundary Conditions ◽  
Ion Channel ◽  
Electrostatic Interactions ◽  
Channel Model ◽  
Field Potential ◽  
Image Method ◽  
Optimization Approach ◽  
Inhomogeneous System ◽  
Reaction Field ◽  
Ion Channel Model

AbstractA multiple-image method is proposed to approximate the reaction-field potential of a source charge inside a finite length cylinder due to the electric polarization of the surrounding membrane and bulk water. When applied to a hybrid ion-channel model, this method allows a fast and accurate treatment of the electrostatic interactions of protein with membrane and solvent. To treat the channel/membrane interface boundary conditions of the electric potential, an optimization approach is used to derive image charges by fitting the reaction-field potential expressed in terms of cylindric harmonics. Meanwhile, additional image charges are introduced to satisfy the boundary conditions at the planar membrane interfaces. In the end, we convert the electrostatic interaction problem in a complex inhomogeneous system of ion channel/membrane/water into one in a homogeneous free space embedded with discrete charges (the source charge and image charges). The accuracy of this method is then validated numerically in calculating the solvation self-energy of a point charge.

Possible ion channel model in crystals of Leu-zervamicin

Peptides ◽  
1992 ◽  
pp. 171-173 ◽  
Author(s):  
I. L. Karle ◽  
J. L. Flippen-Anderson ◽  
S. Agarwalla ◽  
P. Balaram
Keyword(s):  
Ion Channel ◽  
Channel Model ◽  
Ion Channel Model
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