Iron(III) Complexes of Tripodal Monophenolate Ligands as Models for Non-Heme Catechol Dioxygenase Enzymes: Correlation of Dioxygenase Activity with Ligand Stereoelectronic Properties

2009 ◽  
Vol 48 (18) ◽  
pp. 8771-8783 ◽  
Author(s):  
Ramasamy Mayilmurugan ◽  
Kusalendiran Visvaganesan ◽  
Eringathodi Suresh ◽  
Mallayan Palaniandavar
Keyword(s):  
Catechol Dioxygenase ◽  
Stereoelectronic Properties ◽  
Dioxygenase Enzymes ◽  
Dioxygenase Activity

Iron(III) complexes of N2O and N3O donor ligands as functional models for catechol dioxygenase enzymes: ether oxygen coordination tunes the regioselectivity and reactivity

2011 ◽  
Vol 40 (32) ◽  
pp. 8092 ◽  
Author(s):  
Karuppasamy Sundaravel ◽  
Eringathodi Suresh ◽  
Kolandaivel Saminathan ◽  
Mallayan Palaniandavar
Keyword(s):  
Donor Ligands ◽  
Catechol Dioxygenase ◽  
Oxygen Coordination ◽  
Functional Models ◽  
Ether Oxygen ◽  
Dioxygenase Enzymes

To be structurally well-defined or not to be, that is not the question for iron(III)–poly(4-Vinylpyridine-co-acrylamide) to exhibit catechol dioxygenase activity!

2018 ◽  
Vol 106 ◽  
pp. 87-91
Author(s):  
Christopher J. Corcoran ◽  
Christian C. Tang ◽  
Vasiliki Lykourinou ◽  
Andrew C. Terentis ◽  
Alexander Angerhofer ◽  
...  
Keyword(s):  
Catechol Dioxygenase ◽  
Dioxygenase Activity

Catalytic Fate of Two Copper Complexes towards Phenoxazinone Synthase and Catechol Dioxygenase Activity

2017 ◽  
Vol 2 (34) ◽  
pp. 11040-11047 ◽  
Author(s):  
Mamoni Garai ◽  
Dhananjay Dey ◽  
Hare Ram Yadav ◽  
Angshuman Roy Choudhury ◽  
Milan Maji ◽  
...  
Keyword(s):  
Copper Complexes ◽  
Catechol Dioxygenase ◽  
Phenoxazinone Synthase ◽  
Dioxygenase Activity

Catalytic aspects of a nickel(II)–bipyridine complex towards phosphatase and catechol dioxygenase activity

Polyhedron ◽  
2017 ◽  
Vol 129 ◽  
pp. 114-122 ◽  
Author(s):  
Mamoni Garai ◽  
Dhananjay Dey ◽  
Hare Ram Yadav ◽  
Angshuman Roy Choudhury ◽  
Niranjan Kole ◽  
...  
Keyword(s):  
Catechol Dioxygenase ◽  
Dioxygenase Activity

Bioinspired Copper(I) Complexes that Exhibit Monooxygenase and Catechol Dioxygenase Activity

2014 ◽  
Vol 21 (3) ◽  
pp. 1198-1207 ◽  
Author(s):  
Aline Arnold ◽  
Ramona Metzinger ◽  
Christian Limberg
Keyword(s):  
Catechol Dioxygenase ◽  
Dioxygenase Activity

Regulation of the 2-oxoglutarate-dependent dioxygenases and implications for cancer

2014 ◽  
Vol 42 (4) ◽  
pp. 945-951 ◽  
Author(s):  
Margreet C.M. Vissers ◽  
Caroline Kuiper ◽  
Gabi U. Dachs
Keyword(s):  
Molecular Oxygen ◽  
Mammalian Cells ◽  
Hypoxia Inducible Factor ◽  
Future Research ◽  
Wide Range ◽  
The Family ◽  
Metabolic Sensing ◽  
Dioxygenase Enzymes ◽  
Dioxygenase Activity ◽  
Epigenetic Processes

There is growing interest in the family of 2-OG (2-oxoglutarate)-dependent dioxygenase enzymes that catalyse the hydroxylation of a wide range of organic targets. Members of this family that regulate the cell's hypoxic response and epigenetic processes, particularly the demethylation of histones and DNA, have been identified in mammalian cells. The dependence of these enzymes on molecular oxygen and 2-OG as obligatory substrates, together with their need for iron and ascorbate as cofactors, has implications for their role as metabolic sensors. The oxygen-sensing property is utilized by the hydroxylases that regulate hypoxia-inducible factor and this has been well characterized, particularly with respect to tumour biology. However, the potential for metabolic sensing more generally is also of interest, and future research will expand our understanding of the effect of mitochondrial viability and nutrient (iron and ascorbate) supply on 2-OG-dependent dioxygenase activity.

A new iron(III) complex of glycine derivative of amine-chloro substituted phenol ligand: Synthesis, characterization and catechol dioxygenase activity

2012 ◽  
Vol 1029 ◽  
pp. 60-67 ◽  
Author(s):  
Iraj Saberikia ◽  
Elham Safaei ◽  
Mohammad Hossein Kowsari ◽  
Yong-Ill Lee ◽  
Patricia Cotic ◽  
...  
Keyword(s):  
Catechol Dioxygenase ◽  
Glycine Derivative ◽  
Ligand Synthesis ◽  
Dioxygenase Activity

Oxidant dependent oxidation of copper bound catecholate: Catecholase versus catechol dioxygenase activity

Polyhedron ◽  
2015 ◽  
Vol 102 ◽  
pp. 185-192 ◽  
Author(s):  
Dóra Lakk-Bogáth ◽  
Róbert Csonka ◽  
Noémi Lorencz ◽  
Michel Giorgi ◽  
Gábor Speier ◽  
...  
Keyword(s):  
Catechol Dioxygenase ◽  
Dioxygenase Activity

General Cyclopropane Assembly via Enantioselective Redox-Active Carbene Transfer to Aliphatic Olefins

2018 ◽  
Author(s):  
Marc Montesinos-Magraner ◽  
Matteo Costantini ◽  
Rodrigo Ramirez-Contreras ◽  
Michael E. Muratore ◽  
Magnus J. Johansson ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Asymmetric Synthesis ◽  
Chemical Space ◽  
Synthetic Approach ◽  
Asymmetric Cyclopropanation ◽  
Redox Active ◽  
Wide Range ◽  
Leaving Group ◽  
Stereoelectronic Properties ◽  
Carbene Transfer

Asymmetric cyclopropane synthesis currently requires bespoke strategies, methods, substrates and reagents, even when targeting similar compounds. This limits the speed and chemical space available for discovery campaigns. Here we introduce a practical and versatile diazocompound, and we demonstrate its performance in the first unified asymmetric synthesis of functionalized cyclopropanes. We found that the redox-active leaving group in this reagent enhances the reactivity and selectivity of geminal carbene transfer. This effect enabled the asymmetric cyclopropanation of a wide range of olefins including unactivated aliphatic alkenes, enabling the 3-step total synthesis of (–)-dictyopterene A. This unified synthetic approach delivers high enantioselectivities that are independent of the stereoelectronic properties of the functional groups transferred. Our results demonstrate that orthogonally-differentiated diazocompounds are viable and advantageous equivalents of single-carbon chirons<i>.</i>

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