Rational Design to Block Amino Acid Editing of a tRNA Synthetase

2002 ◽  
Vol 124 (25) ◽  
pp. 7286-7287 ◽  
Author(s):  
Richard S. Mursinna ◽  
Susan A. Martinis
Keyword(s):  
Amino Acid ◽  
Rational Design ◽  
Trna Synthetase ◽  
Amino Acid Editing

scholarly journals A Unique Insert of Leucyl-tRNA Synthetase Is Required for Aminoacylation and Not Amino Acid Editing†

Biochemistry ◽  
2007 ◽  
Vol 46 (17) ◽  
pp. 5170-5176 ◽  
Author(s):  
Michael T. Vu ◽  
Susan A. Martinis
Keyword(s):  
Amino Acid ◽  
Trna Synthetase ◽  
Amino Acid Editing

scholarly journals Amino Acid Toxicities of Escherichia coli That Are Prevented by Leucyl-tRNA Synthetase Amino Acid Editing

2007 ◽  
Vol 189 (23) ◽  
pp. 8765-8768 ◽  
Author(s):  
Vrajesh A. Karkhanis ◽  
Anjali P. Mascarenhas ◽  
Susan A. Martinis
Keyword(s):  
Escherichia Coli ◽  
Amino Acids ◽  
Amino Acid ◽  
Trna Synthetase ◽  
Amino Acid Editing

ABSTRACT Leucyl-tRNA synthetase (LeuRS) has evolved an editing function to clear misactivated amino acids. An Escherichia coli-based assay was established to identify amino acids that compromise the fidelity of LeuRS and translation. Multiple nonstandard as well as standard amino acids were toxic to the cell when LeuRS editing was inactivated.

scholarly journals A Viable Amino Acid Editing Activity in the Leucyl-tRNA Synthetase CP1-splicing Domain Is Not Required in the Yeast Mitochondria

2006 ◽  
Vol 281 (44) ◽  
pp. 33217-33225 ◽  
Author(s):  
Vrajesh A. Karkhanis ◽  
Michal T. Boniecki ◽  
Kiranmai Poruri ◽  
Susan A. Martinis
Keyword(s):  
Amino Acid ◽  
Trna Synthetase ◽  
Yeast Mitochondria ◽  
Amino Acid Editing ◽  
Editing Activity

scholarly journals Structural and mutational studies of the amino acid-editing domain from archaeal/eukaryal phenylalanyl-tRNA synthetase

2006 ◽  
Vol 103 (40) ◽  
pp. 14744-14749 ◽  
Author(s):  
H. M. Sasaki ◽  
S.-i. Sekine ◽  
T. Sengoku ◽  
R. Fukunaga ◽  
M. Hattori ◽  
...  
Keyword(s):  
Amino Acid ◽  
Trna Synthetase ◽  
Amino Acid Editing ◽  
Editing Domain

scholarly journals A Paradigm Shift for the Amino Acid Editing Mechanism of Human Cytoplasmic Leucyl-tRNA Synthetase

Biochemistry ◽  
2009 ◽  
Vol 48 (38) ◽  
pp. 8958-8964 ◽  
Author(s):  
Yan Ling Joy Pang ◽  
Susan A. Martinis
Keyword(s):  
Amino Acid ◽  
Paradigm Shift ◽  
Trna Synthetase ◽  
Amino Acid Editing

scholarly journals Modulation of Substrate Specificity within the Amino Acid Editing Site of Leucyl-tRNA Synthetase†

Biochemistry ◽  
2007 ◽  
Vol 46 (11) ◽  
pp. 3331-3337 ◽  
Author(s):  
Yuxin Zhai ◽  
Mir Hussain Nawaz ◽  
Keun Woo Lee ◽  
Erin Kirkbride ◽  
James M. Briggs ◽  
...  
Keyword(s):  
Amino Acid ◽  
Substrate Specificity ◽  
Trna Synthetase ◽  
Editing Site ◽  
Amino Acid Editing
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