Solution Kinetics of CC-1065 A-Ring Opening:  Substituent Effects and General Acid/Base Catalysis

The effect of pH on the kinetics of rat liver arylsulphatases A and B is very similar and shows that two groups with pK values of 4.4-4.5 and 5.7-5.8 are important for enzyme activity. Substrate binding has no effect on the group with a pK of 4.4-4.5; however, the pK of the second group is shifted to 7.1-7.5 in the enzyme-substrate complex. An analysis of the effect of pH on the Ki for sulphate inhibition suggests that HSO4-is the true product. A model is proposed that involves the two ionizing groups identified in the present study in a concerted general acid-base-catalysed mechanism.

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Solution Kinetics of CC-1065 A-Ring Opening: Substituent Effects and General Acid/Base Catalysis

Faculty Opinions recommendation of General acid-base catalysis mediated by nucleobases in the hairpin ribozyme.

General acid base catalysis

Kinetic evidence for the occurrence of general acid-base catalysis in N-methylhydroxylaminolysis of N-ethoxycarbonylphthalimide (NCPH)

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ChemInform Abstract: Influence of Hydrogen Ion Activity and General Acid-Base Catalysis on the Rate of Decomposition of Hydrogen Peroxide by a Novel Nonaggregating Water-Soluble Iron(III) Tetraphenylporphyrin Derivative.

Structures of bacterial polynucleotide kinase in a Michaelis complex with GTP*Mg2+ and 5'-OH oligonucleotide and a product complex with GDP*Mg2+ and 5'-PO4 oligonucleotide reveal a mechanism of general acid-base catalysis and the determinants of phosphoacceptor recognition

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Reverse Protonation Is the Key to General Acid−Base Catalysis in Enolase†,‡

Enforced general acid-base catalysis of complex reactions and its limitations

The effect of pH on the kinetics of arylsulphatases A and B

Structures of bacterial polynucleotide kinase in a Michaelis complex with GTPMg2+ and 5'-OH oligonucleotide and a product complex with GDPMg2+ and 5'-PO4 oligonucleotide reveal a mechanism of general acid-base catalysis and the determinants of phosphoacceptor recognition