Chemical Protein Synthesis: Advances, Challenges, and Outlooks

2020 ◽  
Vol 142 (48) ◽  
pp. 20288-20298
Author(s):  
Yi Tan ◽  
Hongxiang Wu ◽  
Tongyao Wei ◽  
Xuechen Li
Keyword(s):  
Protein Synthesis ◽  
Chemical Protein Synthesis

Diselenide–selenoester ligation for chemical protein synthesis

2019 ◽  
Vol 14 (7) ◽  
pp. 2229-2257 ◽  
Author(s):  
Sameer S. Kulkarni ◽  
Emma E. Watson ◽  
Bhavesh Premdjee ◽  
Kilian W. Conde-Frieboes ◽  
Richard J. Payne
Keyword(s):  
Protein Synthesis ◽  
Chemical Protein Synthesis

Probing the structural basis of the catalytic activity of HIV-1 PR through total chemical protein synthesis

1998 ◽  
Vol 423 (1-2) ◽  
pp. 137-152 ◽  
Author(s):  
Maria Miller ◽  
Manuel Baca ◽  
J.K Mohana Rao ◽  
Stephen B.H Kent
Keyword(s):  
Protein Synthesis ◽  
Catalytic Activity ◽  
Structural Basis ◽  
Chemical Protein Synthesis ◽  
Hiv 1

scholarly journals His6 tag-assisted chemical protein synthesis

2005 ◽  
Vol 102 (14) ◽  
pp. 5014-5019 ◽  
Author(s):  
D. Bang ◽  
S. B. H. Kent
Keyword(s):  
Protein Synthesis ◽  
Chemical Protein Synthesis

Chemical protein synthesis-assisted high-throughput screening strategies for d-peptides in drug discovery

2020 ◽  
Vol 31 (9) ◽  
pp. 2365-2374
Author(s):  
Ying Li ◽  
Xiuxiu Cao ◽  
Changlin Tian ◽  
Ji-Shen Zheng
Keyword(s):  
Protein Synthesis ◽  
Drug Discovery ◽  
High Throughput ◽  
High Throughput Screening ◽  
Screening Strategies ◽  
Chemical Protein Synthesis

ChemInform Abstract: Chemical Protein Synthesis

ChemInform ◽  
2010 ◽  
Vol 31 (22) ◽  
pp. no-no
Author(s):  
Gerd G. Kochendoerfer ◽  
Stephen B. H. Kent
Keyword(s):  
Protein Synthesis ◽  
Chemical Protein Synthesis

scholarly journals Insights into the Mechanism and Catalysis of Peptide Thioester Synthesis by Alkylselenols Provide a New Tool for Chemical Protein Synthesis

Molecules ◽  
2021 ◽  
Vol 26 (5) ◽  
pp. 1386
Author(s):  
Florent Kerdraon ◽  
Gemma Bogard ◽  
Benoît Snella ◽  
Hervé Drobecq ◽  
Muriel Pichavant ◽  
...  
Keyword(s):  
Protein Synthesis ◽  
Total Synthesis ◽  
Adaptive Immunity ◽  
Biologically Active ◽  
Acidic Ph ◽  
Innate And Adaptive Immunity ◽  
Chemotactic Protein ◽  
Chemical Protein Synthesis ◽  
Peptide Thioester ◽  
Peptide Thioesters

While thiol-based catalysts are widely employed for chemical protein synthesis relying on peptide thioester chemistry, this is less true for selenol-based catalysts whose development is in its infancy. In this study, we compared different selenols derived from the selenocysteamine scaffold for their capacity to promote thiol–thioester exchanges in water at mildly acidic pH and the production of peptide thioesters from bis(2-sulfanylethyl)amido (SEA) peptides. The usefulness of a selected selenol compound is illustrated by the total synthesis of a biologically active human chemotactic protein, which plays an important role in innate and adaptive immunity.

Novel Strategies of Peptide Ligation for Accelerating Chemical Protein Synthesis

2020 ◽  
Vol 78 (2) ◽  
pp. 130-139
Author(s):  
Gosuke Hayashi ◽  
Akimitsu Okamoto
Keyword(s):  
Protein Synthesis ◽  
Chemical Protein Synthesis ◽  
Peptide Ligation
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