Biomimetic synthesis of N-nitroso-N-(1-methylacetonyl)-3-methylbutylamine: an unusual carcinogenic nitrosamine in foods of Linxian, China

1987 ◽  
Vol 35 (1) ◽  
pp. 130-132 ◽  
Author(s):  
George M. Singer ◽  
Chuan Ji
Keyword(s):  
Biomimetic Synthesis ◽  
Carcinogenic Nitrosamine

The central role of chromenols in the biomimetic synthesis of structurally diverse natural product scaffolds

Planta Medica ◽  
2012 ◽  
Vol 78 (11) ◽  
Author(s):  
M Cadelis ◽  
D Barker ◽  
BR Copp
Keyword(s):  
Natural Product ◽  
Biomimetic Synthesis

Synthesis and Reactivity of Precolibactin 886

2019 ◽  
Author(s):  
Seth Herzon ◽  
Alan R. Healy ◽  
kevin wernke ◽  
Chung Sub Kim ◽  
Nicholas Lees ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Gene Cluster ◽  
Amino Alcohol ◽  
Biomimetic Synthesis ◽  
Cross Linking ◽  
E Coli ◽  
Hplc Purification ◽  
Structural Assignment ◽  
Biosynthetic Precursor ◽  
Double Oxidation

<div>The clb gene cluster encodes the biosynthesis of metabolites known as precolibactins and colibactins. The clb pathway is found in gut commensal E. coli, and clb metabolites are thought to initiate colorectal cancer via DNA cross-linking. Precolibactin 886 (1) is one of the most complex isolated clb metabolites; it contains a 15-atom macrocycle and an unusual 5-hydroxy-3-oxazoline ring. Here we report confirmation of the structural assignment via a biomimetic synthesis of precolibactin 886 (1) proceeding through the amino alcohol 9. Double oxidation of 9 afforded the unstable α-ketoimine 2 which underwent macrocyclization to precolibactin 886 (1) upon HPLC purification (3% from 9). Studies of the putative precolibactin 886 (1) biosynthetic precursor 2, the model α-ketoimine 25, and the α-dicarbonyl 26 revealed that these compounds are susceptible to nucleophilic rupture of the C36–C37 bond. Moreover, cleavage of 2 produces other known clb metabolites or biosynthetic intermediates. This unexpected reactivity explains the difficulties in isolating full clb metabolites and accounts for the structure of a recently identified colibactin–adenine adduct. The colibactin peptidase ClbP deacylates synthetic precolibactin 886 (1) to form a non-genotoxic pyridone, suggesting precolibactin 886 (1) lies off-path of the major biosynthetic route.</div>

Biomimetic Synthesis of Porous Si3N4 Ceramics

2008 ◽  
Vol 23 (4) ◽  
pp. 763-768 ◽  
Author(s):  
Min LUO
Keyword(s):  
Biomimetic Synthesis ◽  
Porous Si

Biomimetic Synthesis and Analytics of the Human aryl Hydrocarbon Receptor Agonist 1-(furan-2-yl)-2-(1H-indol-3-yl)ethanone, and its 1-(thiophen-2-yl) and 1- (pyrrol-2-yl) Analogues

2013 ◽  
Vol 17 (20) ◽  
pp. 2349-2358 ◽  
Author(s):  
Martina Opietnik ◽  
Kurt Mereiter ◽  
Paul Kosma ◽  
Alois Jungbauer ◽  
Thomas Rosenau
Keyword(s):  
Aryl Hydrocarbon Receptor ◽  
Receptor Agonist ◽  
Biomimetic Synthesis ◽  
Aryl Hydrocarbon ◽  
Aryl Hydrocarbon Receptor Agonist

Biomimetic synthesis and anti-inflammatory evaluation of violacin A analogues

2021 ◽  
pp. 104898
Author(s):  
Wenxi Wu ◽  
Yu Mu ◽  
Bo Liu ◽  
Zixuan Wang ◽  
Peipei Guan ◽  
...  
Keyword(s):  
Biomimetic Synthesis ◽  
Anti Inflammatory

Biomimetic synthesis of Ag NPs and their applications for use in cancer therapy in nursing care

2020 ◽  
pp. 108221
Author(s):  
Yujie Zhang ◽  
Yuanxiu Miao ◽  
Dexiao Xu ◽  
Shumei Liu
Keyword(s):  
Cancer Therapy ◽  
Nursing Care ◽  
Biomimetic Synthesis ◽  
Ag Nps

Biomimetic Synthesis of Meroterpenoids by Dearomatization‐Driven Polycyclization

2019 ◽  
Vol 131 (45) ◽  
pp. 16287-16292 ◽  
Author(s):  
Zachary Powers ◽  
Adam Scharf ◽  
Andrea Cheng ◽  
Feng Yang ◽  
Martin Himmelbauer ◽  
...  
Keyword(s):  
Biomimetic Synthesis

ChemInform Abstract: Biomimetic Synthesis of Pyrido(2,3,4-kl)acridines.

ChemInform ◽  
2010 ◽  
Vol 24 (30) ◽  
pp. no-no
Author(s):  
G. GELLERMAN ◽  
A. RUDI ◽  
Y. KASHMAN
Keyword(s):  
Biomimetic Synthesis
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