Faculty Opinions recommendation of Biomimetic synthesis and optimization of cyclic peptide antibiotics.

2002 ◽  
Author(s):  
Dennis Hall
Keyword(s):  
Cyclic Peptide ◽  
Biomimetic Synthesis ◽  
Peptide Antibiotics

Biomimetic synthesis and optimization of cyclic peptide antibiotics

Nature ◽  
2002 ◽  
Vol 418 (6898) ◽  
pp. 658-661 ◽  
Author(s):  
Rahul M. Kohli ◽  
Christopher T. Walsh ◽  
Michael D. Burkart
Keyword(s):  
Cyclic Peptide ◽  
Biomimetic Synthesis ◽  
Peptide Antibiotics

scholarly journals Induction signals for vancomycin resistance encoded by the vanA gene cluster in Enterococcus faecium.

1996 ◽  
Vol 40 (7) ◽  
pp. 1645-1648 ◽  
Author(s):  
M H Lai ◽  
D R Kirsch
Keyword(s):  
Gene Cluster ◽  
Cyclic Peptide ◽  
Response Regulator ◽  
Polymyxin B ◽  
Vancomycin Resistance ◽  
Sensor Response ◽  
Peptide Antibiotics ◽  
Synthetic Compounds ◽  
Vana Gene ◽  
Two Component

The induction of vancomycin resistance in enterococci containing the vanA gene cluster is thought to be controlled by a two-component sensor-response regulator system encoded by vanR and vanS. Eight inducing compounds were identified by screening a panel of more than 6,800 antibiotics and synthetic compounds including the three tested glycopeptides (vancomycin, avoparcin, and ristocetin), two other cell wall biosynthesis inhibitors (moenomycin and bacitracin), two cyclic peptide antibiotics (antibiotic AO341 beta and polymyxin B), and a macrocyclic lactone antibiotic (moxidectin). Induction activity by structurally unrelated antibiotics suggests that the induction signal is not a structural feature of vancomycin.

scholarly journals Natural Cyclic Peptides as an Attractive Modality for Therapeutics: A Mini Review

Molecules ◽  
2018 ◽  
Vol 23 (8) ◽  
pp. 2080 ◽  
Author(s):  
Muna Abdalla ◽  
Lyndy McGaw
Keyword(s):  
Drug Discovery ◽  
Cyclic Peptides ◽  
Cyclic Peptide ◽  
Pharmacological Properties ◽  
Biological Processes ◽  
Peptide Antibiotics ◽  
Natural Sources ◽  
Biological Targets ◽  
Naturally Occurring ◽  
Wide Range

Peptides are important biomolecules which facilitate the understanding of complex biological processes, which in turn could be serendipitous biological targets for future drugs. They are classified as a unique therapeutic niche and will play an important role as fascinating agents in the pharmaceutical landscape. Until now, more than 40 cyclic peptide drugs are currently in the market, and approximately one new cyclopeptide drug enters the market annually on average. Interestingly, the majority of clinically approved cyclic peptides are derived from natural sources, such as peptide antibiotics and human peptide hormones. In this report, the importance of cyclic peptides is discussed, and their role in drug discovery as interesting therapeutic biomolecules will be highlighted. Recently isolated naturally occurring cyclic peptides from microorganisms, sponges, and other sources with a wide range of pharmacological properties are reviewed herein.

Sequence determination of unknown cyclic peptide antibiotics by fast atom bombardment mass spectrometry

1990 ◽  
Vol 19 (7) ◽  
pp. 395-399 ◽  
Author(s):  
K. Ishikawa ◽  
Y. Niwa ◽  
K. Oishi ◽  
S. Aoi ◽  
T. Takeuchi ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Fast Atom Bombardment ◽  
Cyclic Peptide ◽  
Peptide Antibiotics ◽  
Sequence Determination

scholarly journals Structure and antibacterial activities of new cyclic peptide antibiotics, pargamicins B, C and D, from Amycolatopsis sp. ML1-hF4

2017 ◽  
Vol 70 (5) ◽  
pp. 699-704 ◽  
Author(s):  
Hideki Hashizume ◽  
Ryuichi Sawa ◽  
Kazuma Yamashita ◽  
Yoshio Nishimura ◽  
Masayuki Igarashi
Keyword(s):  
Cyclic Peptide ◽  
Antibacterial Activities ◽  
Peptide Antibiotics
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