Novel Dual Inhibitors of 5-Lipoxygenase and Thromboxane A2 Synthetase: Synthesis and Structure-Activity Relationships of 3-Pyridylmethyl-Substituted 2-Amino-6-hydroxybenzothiazole Derivatives

1994 ◽  
Vol 37 (19) ◽  
pp. 3062-3070 ◽  
Author(s):  
Shigeki Hibi ◽  
Yasushi Okamoto ◽  
Katsuya Tagami ◽  
Hirotoshi Numata ◽  
Naoki Kobayashi ◽  
...  
Keyword(s):  
Thromboxane A2 ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Dual Inhibitors

scholarly journals A Novel Dual Antagonist of Thromboxane A2 and Leukotriene D4 Receptors: Synthesis and Structure–Activity Relationships of Chloroquinolylvinyl Derivatives

2006 ◽  
Vol 54 (5) ◽  
pp. 603-610 ◽  
Author(s):  
Yoshinori Okamoto ◽  
Masaki Yokota ◽  
Soichiro Kawazoe ◽  
Hirokazu Kubota ◽  
Hitoshi Nagaoka ◽  
...  
Keyword(s):  
Thromboxane A2 ◽  
Leukotriene D4 ◽  
Structure Activity Relationships ◽  
Structure Activity

A Novel Dual Antagonist of Thromboxane A2 and Leukotriene D4 Receptors: Synthesis and Structure—Activity Relationships of Chloroquinolylvinyl Derivatives.

ChemInform ◽  
2006 ◽  
Vol 37 (45) ◽  
Author(s):  
Yoshinori Okamoto ◽  
Masaki Yokota ◽  
Soichiro Kawazoe ◽  
Hirokazu Kubota ◽  
Hitoshi Nagaoka ◽  
...  
Keyword(s):  
Thromboxane A2 ◽  
Leukotriene D4 ◽  
Structure Activity Relationships ◽  
Structure Activity

Synthesis and structure-activity relationships of novel benzimidazole and imidazo[4,5-b]pyridine acid derivatives as thromboxane A2 receptor antagonists

1993 ◽  
Vol 36 (9) ◽  
pp. 1175-1187 ◽  
Author(s):  
Eric Nicolai ◽  
Joel Goyard ◽  
Thierry Benchetrit ◽  
Jean Marie Teulon ◽  
Francois Caussade ◽  
...  
Keyword(s):  
Thromboxane A2 ◽  
Receptor Antagonists ◽  
Thromboxane A2 Receptor ◽  
Structure Activity Relationships ◽  
Structure Activity

ChemInform Abstract: Structure-Activity Relationships of (E)-3-(1,4-Benzoquinonyl)-2-((3- pyridyl)alkyl)-2-propenoic Acid Derivatives That Inhibit Both 5- Lipoxygenase and Thromboxane A2 Synthetase.

ChemInform ◽  
2010 ◽  
Vol 27 (48) ◽  
pp. no-no
Author(s):  
S. HIBI ◽  
Y. OKAMOTO ◽  
K. TAGAMI ◽  
H. NUMATA ◽  
N. KOBAYASHI ◽  
...  
Keyword(s):  
Thromboxane A2 ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Propenoic Acid ◽  
Abstract Structure

Synthesis and structure–activity relationships of PI3K/mTOR dual inhibitors from a series of 2-amino-4-methylpyrido[2,3- d ]pyrimidine derivatives

2014 ◽  
Vol 24 (18) ◽  
pp. 4538-4541 ◽  
Author(s):  
Fangbin Han ◽  
Songwen Lin ◽  
Peng Liu ◽  
Jing Tao ◽  
Chongqin Yi ◽  
...  
Keyword(s):  
Pyrimidine Derivatives ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Dual Inhibitors

scholarly journals Chiral disubstituted piperidinyl ureas: a class of dual diacylglycerol lipase-α and ABHD6 inhibitors

MedChemComm ◽  
2017 ◽  
Vol 8 (5) ◽  
pp. 982-988 ◽  
Author(s):  
Hui Deng ◽  
Tom van der Wel ◽  
Richard J. B. H. N. van den Berg ◽  
Adrianus M. C. H. van den Nieuwendijk ◽  
Freek J. Janssen ◽  
...  
Keyword(s):  
Enantioselective Synthesis ◽  
Diacylglycerol Lipase ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Dual Inhibitors

The enantioselective synthesis and structure–activity relationships of deoxy-iminosugar-based triazole ureas as dual inhibitors of DAGLα and ABHD6 were reported.

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