Tyrosine kinase inhibitors. 1. Structure-activity relationships for inhibition of epidermal growth factor receptor tyrosine kinase activity by 2,3-dihydro-2-thioxo-1H-indole-3-alkanoic acids and 2,2'-dithiobis(1H-indole-3-alkanoic acids)

Andrew M. Thompson; Gordon W. Rewcastle; Moana Tercel; Ellen M. Dobrusin; David W. Fry; Alan J. Kraker; William A. Denny

doi:10.1021/jm00069a003

Tyrosine kinase inhibitors. 1. Structure-activity relationships for inhibition of epidermal growth factor receptor tyrosine kinase activity by 2,3-dihydro-2-thioxo-1H-indole-3-alkanoic acids and 2,2'-dithiobis(1H-indole-3-alkanoic acids)

Journal of Medicinal Chemistry ◽

10.1021/jm00069a003 ◽

1993 ◽

Vol 36 (17) ◽

pp. 2459-2469 ◽

Cited By ~ 19

Author(s):

Andrew M. Thompson ◽

Gordon W. Rewcastle ◽

Moana Tercel ◽

Ellen M. Dobrusin ◽

David W. Fry ◽

...

Keyword(s):

Epidermal Growth Factor Receptor ◽

Tyrosine Kinase ◽

Receptor Tyrosine Kinase ◽

Kinase Activity ◽

Kinase Inhibitors ◽

Growth Factor Receptor ◽

Tyrosine Kinase Activity ◽

Structure Activity ◽

Alkanoic Acids ◽

Epidermal Growth

Tyrosine Kinase Inhibitors. 13. Structure−Activity Relationships for Soluble 7-Substituted 4-[(3-Bromophenyl)amino]pyrido[4,3-d]pyrimidines Designed as Inhibitors of the Tyrosine Kinase Activity of the Epidermal Growth Factor Receptor

Journal of Medicinal Chemistry ◽

10.1021/jm970366v ◽

1997 ◽

Vol 40 (24) ◽

pp. 3915-3925 ◽

Cited By ~ 43

Author(s):

Andrew M. Thompson ◽

Donna K. Murray ◽

William L. Elliott ◽

David W. Fry ◽

James A. Nelson ◽

...

Keyword(s):

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Tyrosine Kinase ◽

Kinase Activity ◽

Kinase Inhibitors ◽

Growth Factor Receptor ◽

Tyrosine Kinase Activity ◽

Structure Activity ◽

Epidermal Growth

Inhibition of epidermal growth factor receptor tyrosine kinase activity by hypericin

Biochemical Pharmacology ◽

10.1016/0006-2952(93)90633-8 ◽

1993 ◽

Vol 46 (11) ◽

pp. 1929-1936 ◽

Cited By ~ 50

Author(s):

P. de Witte ◽

P. Agostinis ◽

J. Van Lint ◽

W. Merlevede ◽

J.R. Vandenheede

Keyword(s):

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Tyrosine Kinase ◽

Receptor Tyrosine Kinase ◽

Kinase Activity ◽

Growth Factor Receptor ◽

Tyrosine Kinase Activity ◽

Epidermal Growth

Evidence for the potentiation of epidermal growth factor receptor tyrosine kinase activity by association with the detergent-insoluble cellular cytoskeleton: analysis of intact and carboxy-terminally truncated receptors.

Endocrinology ◽

10.1210/endo.133.6.8243311 ◽

1993 ◽

Vol 133 (6) ◽

pp. 2838-2846 ◽

Cited By ~ 14

Author(s):

A M Gronowski ◽

P J Bertics

Keyword(s):

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Tyrosine Kinase ◽

Receptor Tyrosine Kinase ◽

Kinase Activity ◽

Growth Factor Receptor ◽

Tyrosine Kinase Activity ◽

Epidermal Growth ◽

Cellular Cytoskeleton

Epidermal growth factor receptor tyrosine kinase activity in psoriasis lesions

Journal of the European Academy of Dermatology and Venereology ◽

10.1016/s0926-9959(98)95705-1 ◽

1998 ◽

Vol 11 ◽

pp. S294

Author(s):

R MITURSKI

Keyword(s):

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Tyrosine Kinase ◽

Receptor Tyrosine Kinase ◽

Kinase Activity ◽

Growth Factor Receptor ◽

Tyrosine Kinase Activity ◽

Epidermal Growth

Inhibition of the epidermal growth factor receptor tyrosine kinase activity by leflunomide

FEBS Letters ◽

10.1016/0014-5793(93)81704-4 ◽

1993 ◽

Vol 334 (2) ◽

pp. 161-164 ◽

Cited By ~ 107

Author(s):

Thomas Mattar ◽

Kulvinder Kochhar ◽

Robert Bartlett ◽

Eric G. Bremer ◽

Alison Finnegan

Keyword(s):

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Tyrosine Kinase ◽

Receptor Tyrosine Kinase ◽

Kinase Activity ◽

Growth Factor Receptor ◽

Tyrosine Kinase Activity ◽

Epidermal Growth

ChemInform Abstract: Tyrosine Kinase Inhibitors. Part 7. 7-Amino-4-(phenylamino)- and 7- Amino-4-((phenylmethyl)amino)pyrido(4,3-d)pyrimidines: A New Class of Inhibitors of the Tyrosine Kinase Activity of the Epidermal Growth Factor Receptor.

ChemInform ◽

10.1002/chin.199603160 ◽

2010 ◽

Vol 27 (3) ◽

pp. no-no

Author(s):

A. M. THOMPSON ◽

A. J. BRIDGES ◽

D. W. FRY ◽

A. J. KRAKER ◽

W. A. DENNY

Keyword(s):

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Tyrosine Kinase ◽

Kinase Activity ◽

Kinase Inhibitors ◽

Growth Factor Receptor ◽

Tyrosine Kinase Activity ◽

New Class ◽

Epidermal Growth

Tyrosine kinase inhibitors. 7. 7-amino-4-(phenylamino)- and 7-amino-4-[(phenylmethyl)amino]pyrido[4,3-d]pyrimidines: a new class of inhibitors of the tyrosine kinase activity of the epidermal growth factor receptor

Journal of Medicinal Chemistry ◽

10.1021/jm00019a007 ◽

1995 ◽

Vol 38 (19) ◽

pp. 3780-3788 ◽

Cited By ~ 81

Author(s):

Andrew M. Thompson ◽

Alexander J. Bridges ◽

David W. Fry ◽

Alan J. Kraker ◽

William A. Denny

Keyword(s):

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Tyrosine Kinase ◽

Kinase Activity ◽

Kinase Inhibitors ◽

Growth Factor Receptor ◽

Tyrosine Kinase Activity ◽

New Class ◽

Epidermal Growth

S-Nitrosylation of the epidermal growth factor receptor: A regulatory mechanism of receptor tyrosine kinase activity

Free Radical Biology and Medicine ◽

10.1016/j.freeradbiomed.2008.10.048 ◽

2009 ◽

Vol 46 (4) ◽

pp. 471-479 ◽

Cited By ~ 35

Author(s):

Maribel Murillo-Carretero ◽

Ana Torroglosa ◽

Carmen Castro ◽

Antonio Villalobo ◽

Carmen Estrada

Keyword(s):

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Tyrosine Kinase ◽

Receptor Tyrosine Kinase ◽

Kinase Activity ◽

Regulatory Mechanism ◽

Growth Factor Receptor ◽

Tyrosine Kinase Activity ◽

Epidermal Growth

Modulation of epidermal growth factor receptor interaction with the detergent-insoluble cytoskeleton and its effects on receptor tyrosine kinase activity.

Endocrinology ◽

10.1210/endo.136.5.7720669 ◽

1995 ◽

Vol 136 (5) ◽

pp. 2198-2205 ◽

Cited By ~ 19

Author(s):

A M Gronowski ◽

P J Bertics

Keyword(s):

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Tyrosine Kinase ◽

Receptor Tyrosine Kinase ◽

Kinase Activity ◽

Growth Factor Receptor ◽

Receptor Interaction ◽

Tyrosine Kinase Activity ◽

Epidermal Growth

Epidermal Growth Factor Receptor Immunostaining and Epidermal Growth Factor Receptor-Tyrosine Kinase Activity in Proliferative and Neoplastic Human Endometrium

Tumor Biology ◽

10.1159/000030141 ◽

2000 ◽

Vol 21 (6) ◽

pp. 358-366 ◽

Cited By ~ 9

Author(s):

Roman Miturski ◽

Andrzej Semczuk ◽

Krzysztof Postawski ◽

Jerzy Andrzej Jakowicki

Keyword(s):

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Tyrosine Kinase ◽

Receptor Tyrosine Kinase ◽

Kinase Activity ◽

Growth Factor Receptor ◽

Human Endometrium ◽

Tyrosine Kinase Activity ◽

Epidermal Growth