Effects of certain arylhydroxamic acids on deoxy-ribonucleic acid synthesis by Ehrlich ascites tumor cells in vitro

1968 ◽  
Vol 11 (1) ◽  
pp. 191-194 ◽  
Author(s):  
Glen R. Gale ◽  
John B. Hynes
Keyword(s):  
Tumor Cells ◽  
Ribonucleic Acid ◽  
Acid Synthesis ◽  
Ehrlich Ascites Tumor ◽  
Ehrlich Ascites Tumor Cells ◽  
Ascites Tumor ◽  
Ehrlich Ascites ◽  
Arylhydroxamic Acids

Effects of Actinomycin D on Purine Ribonucleotide Metabolism in Ehrlich Ascites Tumor Cells In Vitro

1974 ◽  
Vol 52 (3) ◽  
pp. 263-267 ◽  
Author(s):  
Floyd F. Snyder ◽  
J. Frank Henderson
Keyword(s):  
Tumor Cells ◽  
Actinomycin D ◽  
De Novo ◽  
Acid Synthesis ◽  
Purine Metabolism ◽  
Ehrlich Ascites Tumor ◽  
Ehrlich Ascites Tumor Cells ◽  
Ascites Tumor ◽  
Ehrlich Ascites

Actinomycin D treatment of Ehrlich ascites tumor cells in vitro causes slight to moderate inhibition of purine ribonucleotide synthesis de novo and from purine bases, and strong inhibition of inosinate dehydrogenase activity. These effects have the same dose–response relationship as inhibition of RNA synthesis by this drug. Daunomycin has similar effects on purine metabolism at a concentration that substantially inhibits nucleic acid synthesis. Actinomycin D treatment leads to elevated intracellular concentrations of ATP and GTP, and the effects of this drug on purine metabolism are believed to be mediated by these purine ribonucleoside triphosphates.

Extramitochondrial Fatty Acid Synthesis in Ehrlich Ascites Tumor Cells Propagated in Vitro and in Vivo

1972 ◽  
Vol 141 (2) ◽  
pp. 506-509 ◽  
Author(s):  
B. N. Pedersen ◽  
A. Gromek ◽  
J. L. Daehnfeldt
Keyword(s):  
Fatty Acid ◽  
Tumor Cells ◽  
Fatty Acid Synthesis ◽  
Acid Synthesis ◽  
Ehrlich Ascites Tumor ◽  
Ehrlich Ascites Tumor Cells ◽  
Ascites Tumor ◽  
Ehrlich Ascites

Effects of Bikaverin on purine nucleotide synthesis and catabolism in ehrlich ascites tumor cells in vitro

1977 ◽  
Vol 26 (21) ◽  
pp. 1973-1977 ◽  
Author(s):  
J.Frank Henderson ◽  
Mary L. Battell ◽  
George Zombor ◽  
Jan Fuska ◽  
P. Nemec
Keyword(s):  
Tumor Cells ◽  
Ehrlich Ascites Tumor ◽  
Purine Nucleotide ◽  
Ehrlich Ascites Tumor Cells ◽  
Ascites Tumor ◽  
Nucleotide Synthesis ◽  
Ehrlich Ascites

NUCLEIC ACTD METABOLISM IN INTESTINAL MUCOSA: IV. THE EFFECT OF GLUCOSE ON INCORPORATION OF C14-FORMATE INTO PURINES AND PYRIMIDINES IN VITRO

1963 ◽  
Vol 41 (1) ◽  
pp. 1557-1564
Author(s):  
Beryl E. Stewart ◽  
S. H. Zbarsky
Keyword(s):  
Tumor Cells ◽  
Ehrlich Ascites Tumor ◽  
Ehrlich Ascites Tumor Cells ◽  
Ascites Tumor ◽  
Rat Intestine ◽  
Maximal Stimulation ◽  
Ehrlich Ascites ◽  
Effect Of Glucose ◽  
Rna And Dna

Slices of rat intestine were incubated in Krebs–Ringer phosphate buffer in the presence of C14-formate. The addition of glucose to the buffer stimulated the incorporation of radioactivity into the purines and, in some instances, the pyrimidines of the acid-soluble fraction and nucleic acids of the tissue. With Ehrlich ascites tumor cells studied under similar conditions, the increase in uptake of C14-formate into the purines was somewhat greater. The data suggest also that maximal stimulation with slices of intestine is obtained at glucose concentrations somewhat higher than that required with Ehrlich ascites tumor cells. A finding of interest was the increased incorporation of C14-formate into the thymine of the intestinal DNA in the presence of glucose. This result has not been observed with Ehrlich ascites tumor cells. Slices of rat intestine incubated for 2 hours in the presence of glucose had a higher content of RNA and DNA than tissue not exposed to added glucose.

Effects of glucose and oxygen on the metabolism of glycine by ehrlich ascites tumor cells in vitro

1963 ◽  
Vol 74 ◽  
pp. 24-32 ◽  
Author(s):  
Anna M. Williams ◽  
J.S. Finlayson ◽  
Jean K. Tews
Keyword(s):  
Tumor Cells ◽  
Ehrlich Ascites Tumor ◽  
Ehrlich Ascites Tumor Cells ◽  
Ascites Tumor ◽  
Ehrlich Ascites

scholarly journals STUDIES ON RIBONUCLEIC ACID ISOLATED FROM EHRLICH ASCITES TUMOR CELLS

1957 ◽  
Vol 43 (10) ◽  
pp. 857-860 ◽  
Author(s):  
R. A. Brown ◽  
M. C. Davies ◽  
J. S. Colter ◽  
J. B. Logan ◽  
D. Kritchevsky
Keyword(s):  
Tumor Cells ◽  
Ribonucleic Acid ◽  
Ehrlich Ascites Tumor ◽  
Ehrlich Ascites Tumor Cells ◽  
Ascites Tumor ◽  
Ehrlich Ascites
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