The Role of the 5'-Hydroxyl Group of Adenosine in Determining Substrate Specificity for Adenosine Deaminase

1967 ◽  
Vol 10 (5) ◽  
pp. 908-912 ◽  
Author(s):  
Alexander. Bloch ◽  
Morris J. Robins ◽  
James R. McCarthy
Keyword(s):  
Substrate Specificity ◽  
Adenosine Deaminase ◽  
Hydroxyl Group

Substrate specificity of adenosine deaminase—Function of the 5′-hydroxyl group of adenosine

1980 ◽  
Vol 9 (4) ◽  
pp. 423-433 ◽  
Author(s):  
Vasu Nair ◽  
Ronald J. Wiechert
Keyword(s):  
Substrate Specificity ◽  
Adenosine Deaminase ◽  
Hydroxyl Group

Insights into the Role of Hydroxyl Group on Carboxyl-modified MWCNTs in Accelerating Atenolol Removal by Fe(III)/H2O2 System

2021 ◽  
pp. 130581
Author(s):  
Shuai Shao ◽  
Gaobo Wang ◽  
Zhimin Gong ◽  
Mengjie Wang ◽  
Jianhua Hu ◽  
...  
Keyword(s):  
Hydroxyl Group ◽  
H2o2 System

Possible role of a histidine residue in the substrate specificity of yeast d-aspartate oxidase

2015 ◽  
pp. mvv108 ◽  
Author(s):  
Shouji Takahashi ◽  
Kozue Shimada ◽  
Shunsuke Nozawa ◽  
Masaru Goto ◽  
Katsumasa Abe ◽  
...  
Keyword(s):  
Substrate Specificity ◽  
Histidine Residue

The Role of Hydroxyl Group Acidity on the Activity of Silica-Supported Secondary Amines for the Self-Condensation ofn-Butanal

ChemSusChem ◽  
2014 ◽  
Vol 8 (3) ◽  
pp. 466-472 ◽  
Author(s):  
Sankaranarayanapillai Shylesh ◽  
David Hanna ◽  
Joseph Gomes ◽  
Christian G. Canlas ◽  
Martin Head-Gordon ◽  
...  
Keyword(s):  
The Self ◽  
Secondary Amines ◽  
Hydroxyl Group

The Role of G22 A Adenosine Deaminase 1 Gene Polymorphism and the Activities of ADA Isoenzymes in Fertile and Infertile Men

Urology ◽  
2015 ◽  
Vol 86 (4) ◽  
pp. 730-734
Author(s):  
Amir Fattahi ◽  
Iraj Khodadadi ◽  
Iraj Amiri ◽  
Zeinab Latifi ◽  
Marzieh Ghorbani ◽  
...  
Keyword(s):  
Gene Polymorphism ◽  
Adenosine Deaminase ◽  
Infertile Men

Role of adenosine in postprandial and reactive hyperemia in canine jejunum

1992 ◽  
Vol 263 (4) ◽  
pp. G487-G493 ◽  
Author(s):  
D. R. Sawmiller ◽  
C. C. Chou
Keyword(s):  
Blood Flow ◽  
Oxygen Consumption ◽  
Adenosine Deaminase ◽  
Reactive Hyperemia ◽  
Concentration Difference ◽  
Adenosine Concentration ◽  
Anesthetized Dogs ◽  
Series Of Experiments ◽  
Increased Blood Flow

The role of adenosine in postprandial jejunal hyperemia was investigated by determining the effect of placement of predigested food into the jejunal lumen on blood flow and oxygen consumption before and during intra-arterial infusion of dipyridamole (1.5 microM arterial concn) or adenosine deaminase (9 U/ml arterial concn) in anesthetized dogs. Neither drug significantly altered resting jejunal blood flow and oxygen consumption. Before dipyridamole or deaminase, food placement increased blood flow by 30-36%, 26-42%, and 21-46%, and oxygen consumption by 13-22%, 21-22%, and 26-29%, during 0- to 3-, 4- to 7-, and 8- to 11-min placement periods, respectively. Adenosine deaminase abolished the entire 11-min hyperemia, whereas dipyridamole significantly enhanced the initial 7-min hyperemia (45-49%). Both drugs abolished the initial 7-min food-induced increase in oxygen consumption. Dipyridamole attenuated (14%), whereas deaminase did not alter (28%), the increased oxygen consumption that occurred at 8-11 min. Adenosine deaminase also prevented the food-induced increase in venoarterial adenosine concentration difference. In separate series of experiments, luminal placement of food significantly increased jejunal lymphatic adenosine concentration and release. Also, reactive hyperemia was accompanied by an increase in venous adenosine concentration and release. This study provides further evidence to support the thesis that adenosine plays a role in postprandial and reactive hyperemia in the canine jejunum.

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