Synthesis and Biological Evaluation of a New Set of Pyrazolo[1,5-c]quinazoline-2-carboxylates as Novel Excitatory Amino Acid Antagonists

Flavia Varano; Daniela Catarzi; Vittoria Colotta; Guido Filacchioni; Alessandro Galli; Chiara Costagli; Vincenzo Carlà

doi:10.1021/jm010995b

Synthesis and Biological Evaluation of a New Set of Pyrazolo[1,5-c]quinazoline-2-carboxylates as Novel Excitatory Amino Acid Antagonists

Journal of Medicinal Chemistry ◽

10.1021/jm010995b ◽

2002 ◽

Vol 45 (5) ◽

pp. 1035-1044 ◽

Cited By ~ 61

Author(s):

Flavia Varano ◽

Daniela Catarzi ◽

Vittoria Colotta ◽

Guido Filacchioni ◽

Alessandro Galli ◽

...

Keyword(s):

Amino Acid ◽

Excitatory Amino Acid ◽

Biological Evaluation ◽

Amino Acid Antagonists ◽

Excitatory Amino Acid Antagonists ◽

Synthesis And Biological Evaluation

Effects ofin situadministration of excitatory amino acid antagonists on rapid microglial and astroglial reactions in rat hippocampus following traumatic brain injury

Neurological Research ◽

10.1179/016164107x251745 ◽

2008 ◽

Vol 30 (4) ◽

pp. 420-429 ◽

Cited By ~ 9

Author(s):

Takeshi Suma ◽

Morimichi Koshinaga ◽

Masamichi Fukushima ◽

Tsuneo Kano ◽

Yoichi Katayama

Keyword(s):

Traumatic Brain Injury ◽

Amino Acid ◽

Brain Injury ◽

Excitatory Amino Acid ◽

Rat Hippocampus ◽

Amino Acid Antagonists ◽

Excitatory Amino Acid Antagonists

Excitatory Amino Acid Antagonists and Pentylenetetrazol-induced Seizures During Ontogenesis. IV. Effects of CGP 39551

Pharmacology Biochemistry and Behavior ◽

10.1016/s0091-3057(96)00245-6 ◽

1997 ◽

Vol 56 (3) ◽

pp. 493-498 ◽

Cited By ~ 10

Author(s):

Libor Velíšek ◽

Dana Vachová ◽

Pavel Mareš

Keyword(s):

Amino Acid ◽

Excitatory Amino Acid ◽

Cgp 39551 ◽

Amino Acid Antagonists ◽

Excitatory Amino Acid Antagonists

Effects of excitatory amino acid antagonists on dendrotoxin-induced increases in neurotransmitter release and epileptiform bursting in rat hippocampus in vitro

Journal of Neuroscience Research ◽

10.1002/(sici)1097-4547(19970615)48:6<499::aid-jnr2>3.0.co;2-5 ◽

1997 ◽

Vol 48 (6) ◽

pp. 499-506 ◽

Cited By ~ 9

Author(s):

F. Dorandeu ◽

J. Wetherell ◽

I. Pernot-Marino ◽

J.E.H. Tattersall ◽

P. Fosbraey ◽

...

Keyword(s):

Amino Acid ◽

Neurotransmitter Release ◽

Excitatory Amino Acid ◽

Rat Hippocampus ◽

Amino Acid Antagonists ◽

Excitatory Amino Acid Antagonists

Behavioural and eeg effects of some excitatory amino acid antagonists

Pharmacological Research Communications ◽

10.1016/s0031-6989(88)80017-1 ◽

1988 ◽

Vol 20 (5) ◽

pp. 409-410 ◽

Cited By ~ 1

Author(s):

M. Benedetti ◽

S. Sagratella ◽

A. Scotti de Carolis

Keyword(s):

Amino Acid ◽

Excitatory Amino Acid ◽

Amino Acid Antagonists ◽

Excitatory Amino Acid Antagonists

Synthesis and Biological Evaluation of Novel Neuroprotective Pyridazine Derivatives as Excitatory Amino Acid Transporter 2 (EAAT2) Activators

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.7b00383 ◽

2017 ◽

Vol 60 (12) ◽

pp. 5216-5221 ◽

Cited By ~ 5

Author(s):

Alessia Chelini ◽

Simone Brogi ◽

Marco Paolino ◽

Angela Di Capua ◽

Andrea Cappelli ◽

...

Keyword(s):

Amino Acid ◽

Excitatory Amino Acid ◽

Amino Acid Transporter ◽

Biological Evaluation ◽

Excitatory Amino Acid Transporter ◽

Acid Transporter ◽

Pyridazine Derivatives ◽

Synthesis And Biological Evaluation

Therapeutic potential of excitatory amino acid antagonists: channel blockers and 2,3-benzodiazepines

Trends in Pharmacological Sciences ◽

10.1016/0165-6147(93)90005-5 ◽

1993 ◽

Vol 14 (9) ◽

pp. 325-331 ◽

Cited By ~ 217

Author(s):

Michael A. Rogawski

Keyword(s):

Amino Acid ◽

Therapeutic Potential ◽

Excitatory Amino Acid ◽

Channel Blockers ◽

Amino Acid Antagonists ◽

Excitatory Amino Acid Antagonists

Differential effects of excitatory amino acid antagonists on dorsal horn nociceptive neurones in the rat

Brain Research ◽

10.1016/0006-8993(90)91195-m ◽

1990 ◽

Vol 506 (1) ◽

pp. 31-39 ◽

Cited By ~ 260

Author(s):

Anthony H. Dickenson ◽

Ann F. Sullivan

Keyword(s):

Amino Acid ◽

Dorsal Horn ◽

Excitatory Amino Acid ◽

Differential Effects ◽

Amino Acid Antagonists ◽

Excitatory Amino Acid Antagonists

The role of putative excitatory amino acid neurotransmitters in the initiation of locomotion in the lamprey spinal cord. I. The effects of excitatory amino acid antagonists

Brain Research ◽

10.1016/0006-8993(85)91229-6 ◽

1985 ◽

Vol 360 (1-2) ◽

pp. 139-148 ◽

Cited By ~ 55

Author(s):

Lennart Brodin ◽

Sten Grillner

Keyword(s):

Spinal Cord ◽

Amino Acid ◽

Excitatory Amino Acid ◽

Amino Acid Neurotransmitters ◽

Amino Acid Antagonists ◽

Excitatory Amino Acid Antagonists

Hypoxic Neurodegeneration in Culture: Calcium Influx, Electron Microscopy, and Neuroprotection with Excitatory Amino Acid Antagonists

Annals of the New York Academy of Sciences ◽

10.1111/j.1749-6632.1992.tb24563.x ◽

1992 ◽

Vol 648 (1 Neurotoxins a) ◽

pp. 303-305 ◽

Cited By ~ 7

Author(s):

FRANK W. MARCOUX ◽

MARK L. WEBER ◽

ALBERT W. PROBERT ◽

MARK A. DOMINICK

Keyword(s):

Electron Microscopy ◽

Amino Acid ◽

Excitatory Amino Acid ◽

Calcium Influx ◽

Amino Acid Antagonists ◽

Excitatory Amino Acid Antagonists

The pharmacology of excitatory amino acid antagonists in an animal model of stroke

European Neuropsychopharmacology ◽

10.1016/0924-977x(94)90091-4 ◽

1994 ◽

Vol 4 (3) ◽

pp. 279-281

Author(s):

R. Gill

Keyword(s):

Animal Model ◽

Amino Acid ◽

Excitatory Amino Acid ◽

Amino Acid Antagonists ◽

Excitatory Amino Acid Antagonists