Nα-Imidazolylalkyl and Pyridylalkyl Derivatives of Histaprodifen:  Synthesis and in Vitro Evaluation of Highly Potent Histamine H1-Receptor Agonists

Sonja Menghin; Heinz H. Pertz; Kai Kramer; Roland Seifert; Walter Schunack; Sigurd Elz

doi:10.1021/jm0309147

Nα-Imidazolylalkyl and Pyridylalkyl Derivatives of Histaprodifen: Synthesis and in Vitro Evaluation of Highly Potent Histamine H1-Receptor Agonists

Journal of Medicinal Chemistry ◽

10.1021/jm0309147 ◽

2003 ◽

Vol 46 (25) ◽

pp. 5458-5470 ◽

Cited By ~ 19

Author(s):

Sonja Menghin ◽

Heinz H. Pertz ◽

Kai Kramer ◽

Roland Seifert ◽

Walter Schunack ◽

...

Keyword(s):

H1 Receptor ◽

In Vitro Evaluation ◽

Histamine H1 Receptor ◽

Receptor Agonists ◽

Derivatives Of

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Histaprodifens: Synthesis, Pharmacological in Vitro Evaluation, and Molecular Modeling of a New Class of Highly Active and Selective Histamine H1-Receptor Agonists†

Journal of Medicinal Chemistry ◽

10.1021/jm991056a ◽

2000 ◽

Vol 43 (6) ◽

pp. 1071-1084 ◽

Cited By ~ 55

Author(s):

Sigurd Elz ◽

Kai Kramer ◽

Heinz H. Pertz ◽

Heiner Detert ◽

Anton M. ter Laak ◽

...

Keyword(s):

Molecular Modeling ◽

H1 Receptor ◽

In Vitro Evaluation ◽

Histamine H1 Receptor ◽

Receptor Agonists ◽

New Class ◽

Highly Active

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ChemInform Abstract: Nα-Alkylated Derivatives of 2-Phenylhistamines: Synthesis and in vitro Activity of Potent Histamine H1-Receptor Agonists.

ChemInform ◽

10.1002/chin.199902257 ◽

2010 ◽

Vol 30 (2) ◽

pp. no-no

Author(s):

K. KRAMER ◽

S. ELZ ◽

H. H. PERTZ ◽

W. SCHUNACK

Keyword(s):

Vitro Activity ◽

In Vitro Activity ◽

H1 Receptor ◽

Histamine H1 Receptor ◽

Receptor Agonists ◽

Derivatives Of

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ChemInform Abstract: Histaprodifens: Synthesis, Pharmacological in vitro Evaluation, and Molecular Modeling of a New Class of Highly Active and Selective Histamine H1-Receptor Agonists.

ChemInform ◽

10.1002/chin.200025133 ◽

2010 ◽

Vol 31 (25) ◽

pp. no-no

Author(s):

Sigurd Elz ◽

Kai Kramer ◽

Heinz H. Pertz ◽

Heiner Detert ◽

Anton M. ter Laak ◽

...

Keyword(s):

Molecular Modeling ◽

H1 Receptor ◽

In Vitro Evaluation ◽

Histamine H1 Receptor ◽

Receptor Agonists ◽

New Class ◽

Highly Active

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Nα-alkylated derivatives of 2-phenylhistamines: Synthesis and in vitro activity of potent histamine H1-receptor agonists

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/s0960-894x(98)00461-2 ◽

1998 ◽

Vol 8 (18) ◽

pp. 2583-2588 ◽

Cited By ~ 5

Author(s):

K. Kramer ◽

S. Elz ◽

H.H. Pertz ◽

W. Schunack

Keyword(s):

Vitro Activity ◽

In Vitro Activity ◽

H1 Receptor ◽

Histamine H1 Receptor ◽

Receptor Agonists ◽

Derivatives Of

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Intact Cell Binding for In Vitro Prediction of Sedative and Non-sedative Histamine H1–Receptor Antagonists Based on Receptor Internalization

Journal of Pharmacological Sciences ◽

10.1254/jphs.fp0071865 ◽

2008 ◽

Vol 107 (1) ◽

pp. 66-79 ◽

Cited By ~ 7

Author(s):

Shigeru Hishinuma ◽

Yuko Sato ◽

Yusuke Kobayashi ◽

Hiroshi Komazaki ◽

Masaki Saito

Keyword(s):

Intact Cell ◽

Receptor Internalization ◽

Cell Binding ◽

H1 Receptor ◽

Receptor Antagonists ◽

Histamine H1 Receptor

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In vivo biliary excretion and in vitro cellular accumulation of thyroxine by rats or cultured rat hepatocytes treated with a novel histamine H1-receptor antagonist

Archives of Toxicology ◽

10.1007/bf01977630 ◽

1990 ◽

Vol 64 (6) ◽

pp. 474-481 ◽

Cited By ~ 5

Author(s):

Alan Poole ◽

Deborah Pritchard ◽

Richard B. Jones ◽

Linda Catto ◽

Thomas Leonard

Keyword(s):

Receptor Antagonist ◽

Biliary Excretion ◽

Rat Hepatocytes ◽

H1 Receptor ◽

Cellular Accumulation ◽

Histamine H1 Receptor ◽

Cultured Rat Hepatocytes ◽

H1 Receptor Antagonist

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Structure-Activity Relationships of Histamine H1-Receptor Agonists

Mini-Reviews in Medicinal Chemistry ◽

10.2174/1389557043403198 ◽

2004 ◽

Vol 4 (9) ◽

pp. 935-940 ◽

Cited By ~ 11

Author(s):

Heinz Pertz ◽

Sigurd Elz ◽

Walter Schunack

Keyword(s):

H1 Receptor ◽

Histamine H1 Receptor ◽

Structure Activity Relationships ◽

Receptor Agonists ◽

Structure Activity

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Effect of Histamine H1 Receptor Antagonists on TARC/CCL17 and MDC/CCL22 Production from CD14+ Cells Induced by Antigenic Stimulation in vitro

International Archives of Allergy and Immunology ◽

10.1159/000318720 ◽

2011 ◽

Vol 155 (1) ◽

pp. 38-51 ◽

Cited By ~ 5

Author(s):

Naruo Shoji ◽

Kazuhito Asano ◽

Atsuko Furuta ◽

Kojiro Hirano ◽

Harumi Suzaki

Keyword(s):

Antigenic Stimulation ◽

H1 Receptor ◽

Receptor Antagonists ◽

Histamine H1 Receptor

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Syntheses and in vitro evaluation of fluorinated naphthoxazines as dopamine D2/D3 receptor agonists: radiosynthesis, ex vivo biodistribution and autoradiography of [18F]F-PHNO

Nuclear Medicine and Biology ◽

10.1016/j.nucmedbio.2006.11.001 ◽

2007 ◽

Vol 34 (2) ◽

pp. 195-203 ◽

Cited By ~ 18

Author(s):

Neil Vasdev ◽

Philip Seeman ◽

Armando Garcia ◽

Winston T. Stableford ◽

José N. Nobrega ◽

...

Keyword(s):

Ex Vivo ◽

D3 Receptor ◽

In Vitro Evaluation ◽

Receptor Agonists ◽

Dopamine D2 ◽

Ex Vivo Biodistribution

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Synthesis and in Vitro Evaluation of Quaternary Ammonium Derivatives of Chlorambucil and Melphalan, Anticancer Drugs Designed for the Chemotherapy of Chondrosarcoma

Journal of Medicinal Chemistry ◽

10.1021/jm010926x ◽

2002 ◽

Vol 45 (10) ◽

pp. 2116-2119 ◽

Cited By ~ 29

Author(s):

Isabelle Giraud ◽

Maryse Rapp ◽

Jean-Claude Maurizis ◽

Jean-Claude Madelmont

Keyword(s):

Anticancer Drugs ◽

Quaternary Ammonium ◽

In Vitro Evaluation ◽

Derivatives Of

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