Identification of Novel p38α MAP Kinase Inhibitors Using Fragment-Based Lead Generation

2005 ◽  
Vol 48 (2) ◽  
pp. 414-426 ◽  
Author(s):  
Adrian L. Gill ◽  
Martyn Frederickson ◽  
Anne Cleasby ◽  
Steven J. Woodhead ◽  
Maria G. Carr ◽  
...  
Keyword(s):  
Map Kinase ◽  
Kinase Inhibitors ◽  
Lead Generation ◽  
P38α Map Kinase

N-Phenyl-N-purin-6-yl ureas: The design and synthesis of p38α MAP kinase inhibitors

2003 ◽  
Vol 13 (6) ◽  
pp. 1191-1194 ◽  
Author(s):  
Zehong Wan ◽  
Jeffrey C. Boehm ◽  
Michael J. Bower ◽  
Shouki Kassis ◽  
John C. Lee ◽  
...  
Keyword(s):  
Map Kinase ◽  
Kinase Inhibitors ◽  
Design And Synthesis ◽  
P38α Map Kinase

Design of Potent and Selective 2-Aminobenzimidazole-Based p38α MAP Kinase Inhibitors with Excellent in Vivo Efficacy

2005 ◽  
Vol 48 (7) ◽  
pp. 2270-2273 ◽  
Author(s):  
Alfonso de Dios ◽  
Chuan Shih ◽  
Beatriz López de Uralde ◽  
Concepción Sánchez ◽  
Miriam del Prado ◽  
...  
Keyword(s):  
Map Kinase ◽  
Kinase Inhibitors ◽  
In Vivo Efficacy ◽  
P38α Map Kinase

Dibenzepinones, dibenzoxepines and benzosuberones based p38α MAP kinase inhibitors: Their pharmacophore modelling, 3D-QSAR and docking studies

2019 ◽  
Vol 110 ◽  
pp. 175-185 ◽  
Author(s):  
Mohemmed Faraz Khan ◽  
Garima Verma ◽  
Perwez Alam ◽  
Mymoona Akhter ◽  
Md Afroz Bakht ◽  
...  
Keyword(s):  
Map Kinase ◽  
Kinase Inhibitors ◽  
3D Qsar ◽  
Docking Studies ◽  
Pharmacophore Modelling ◽  
P38α Map Kinase

Thermal Denaturation:  A Method to Rank Slow Binding, High-Affinity P38α MAP Kinase Inhibitors

2003 ◽  
Vol 46 (22) ◽  
pp. 4669-4675 ◽  
Author(s):  
Rachel R. Kroe ◽  
John Regan ◽  
Al Proto ◽  
Gregory W. Peet ◽  
Tapon Roy ◽  
...  
Keyword(s):  
Map Kinase ◽  
Thermal Denaturation ◽  
Kinase Inhibitors ◽  
High Affinity ◽  
P38α Map Kinase

scholarly journals An optimized and versatile synthesis to pyridinylimidazole-type p38α mitogen activated protein kinase inhibitors

2015 ◽  
Vol 13 (43) ◽  
pp. 10699-10704 ◽  
Author(s):  
Ahmed El-Gokha ◽  
Stefan A. Laufer ◽  
Pierre Koch
Keyword(s):  
Protein Kinase ◽  
Map Kinase ◽  
Kinase Inhibitors ◽  
Protein Kinase Inhibitors ◽  
Mitogen Activated Protein Kinase ◽  
Synthetic Approach ◽  
Mitogen Activated Protein ◽  
P38α Map Kinase

An optimized and diverse synthetic approach for the preparation of potent pyridinylimidazole-based p38α MAP kinase inhibitors is reported.

Identification of p38α MAP kinase inhibitors by pharmacophore based virtual screening

2014 ◽  
Vol 49 ◽  
pp. 18-24 ◽  
Author(s):  
Rahul P. Gangwal ◽  
Nihar R. Das ◽  
Kaushik Thanki ◽  
Mangesh V. Damre ◽  
Gaurao V. Dhoke ◽  
...  
Keyword(s):  
Virtual Screening ◽  
Map Kinase ◽  
Kinase Inhibitors ◽  
P38α Map Kinase

Synthesis and Biological Testing of N-Aminoimidazole-Based p38α MAP Kinase Inhibitors

ChemMedChem ◽  
2010 ◽  
Vol 5 (7) ◽  
pp. 1134-1142 ◽  
Author(s):  
Claudia Bracht ◽  
Dominik R. J. Hauser ◽  
Verena Schattel ◽  
Wolfgang Albrecht ◽  
Stefan A. Laufer
Keyword(s):  
Map Kinase ◽  
Kinase Inhibitors ◽  
Biological Testing ◽  
P38α Map Kinase
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