Synthesis and Mechanism of Action Studies of a Series of Norindenoisoquinoline Topoisomerase I Poisons Reveal an Inhibitor with a Flipped Orientation in the Ternary DNA−Enzyme−Inhibitor Complex As Determined by X-ray Crystallographic Analysis

2005 ◽  
Vol 48 (15) ◽  
pp. 4803-4814 ◽  
Author(s):  
Alexandra Ioanoviciu ◽  
Smitha Antony ◽  
Yves Pommier ◽  
Bart L. Staker ◽  
Lance Stewart ◽  
...  
Keyword(s):  
Mechanism Of Action ◽  
Topoisomerase I ◽  
Enzyme Inhibitor ◽  
Crystallographic Analysis ◽  
X Ray ◽  
Inhibitor Complex

Synthesis and SAR of Thrombin Inhibitors Incorporating a Novel 4-Amino-Morpholinone Scaffold:  Analysis of X-ray Crystal Structure of Enzyme Inhibitor Complex

2003 ◽  
Vol 46 (19) ◽  
pp. 3985-4001 ◽  
Author(s):  
Jonas W. Nilsson ◽  
Ingemar Kvarnström ◽  
Djordje Musil ◽  
Ingemar Nilsson ◽  
Bertil Samulesson
Keyword(s):  
Crystal Structure ◽  
Enzyme Inhibitor ◽  
Thrombin Inhibitors ◽  
X Ray ◽  
Inhibitor Complex

Inhibition of trypsin by carbobenzyloxylysyl chloromethyl ketone: 13C NMR and x-ray diffraction analyses of the enzyme-inhibitor complex

Tetrahedron ◽  
1986 ◽  
Vol 42 (12) ◽  
pp. 3269-3276 ◽  
Author(s):  
A.I. Scott ◽  
N.E. Mackenzie ◽  
J.P.G. Malthouse ◽  
W.U. Primrose ◽  
P.E. Fagerness ◽  
...  
Keyword(s):  
13C Nmr ◽  
Enzyme Inhibitor ◽  
X Ray Diffraction ◽  
Chloromethyl Ketone ◽  
X Ray ◽  
Inhibitor Complex

scholarly journals Exploring the divalent effect in fucosidase inhibition with stereoisomeric pyrrolidine dimers

2016 ◽  
Vol 14 (20) ◽  
pp. 4718-4727 ◽  
Author(s):  
Audrey Hottin ◽  
Daniel W. Wright ◽  
Elena Moreno-Clavijo ◽  
Antonio J. Moreno-Vargas ◽  
Gideon J. Davies ◽  
...  
Keyword(s):  
Enzyme Inhibitor ◽  
Mechanisms Of Action ◽  
Crystallographic Analysis ◽  
Enzymatic Assays ◽  
Inhibitor Complex

The possible mechanisms of action of a dimeric fucosidase inhibitor are discussed through enzymatic assays of a series of analogues and crystallographic analysis of the enzyme-inhibitor complex.

scholarly journals Neutron and X-ray Crystal Structures of a Perdeuterated Enzyme Inhibitor Complex Reveal the Catalytic Proton Network of the Toho-1 β-Lactamase for the Acylation Reaction

2012 ◽  
Vol 288 (7) ◽  
pp. 4715-4722 ◽  
Author(s):  
Stephen J. Tomanicek ◽  
Robert F. Standaert ◽  
Kevin L. Weiss ◽  
Andreas Ostermann ◽  
Tobias E. Schrader ◽  
...  
Keyword(s):  
Crystal Structures ◽  
Enzyme Inhibitor ◽  
Acylation Reaction ◽  
X Ray ◽  
Inhibitor Complex
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