Design, Synthesis and Discovery of Picomolar Selective α4β2 Nicotinic Acetylcholine Receptor Ligands

Journal of Medicinal Chemistry ◽

10.1021/jm4008455 ◽

2013 ◽

Vol 56 (21) ◽

pp. 8404-8421 ◽

Author(s):

Venkata M. Yenugonda ◽

Yingxian Xiao ◽

Edward D. Levin ◽

Amir H. Rezvani ◽

Thao Tran ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Receptor Ligands ◽

Nicotinic Acetylcholine ◽

Design Synthesis

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Sensitivity of Rat Brain Tachykinin Receptors to Nicotinic Acetylcholine Receptor Ligands

Annals of the New York Academy of Sciences ◽

10.1111/j.1749-6632.1990.tb40516.x ◽

1990 ◽

Vol 594 (1 Neuropeptides) ◽

pp. 423-424

Author(s):

V. I. TSETLIN ◽

YU. N. UTKIN ◽

E. M. LAZAKOVICH

Keyword(s):

Rat Brain ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Receptor Ligands ◽

Nicotinic Acetylcholine ◽

Tachykinin Receptors

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Design, synthesis and biological evaluation of 1,4-Diazobicylco[3.2.2]nonane derivatives as α7-Nicotinic acetylcholine receptor PET/CT imaging agents and agonists for Alzheimer's disease

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2018.09.064 ◽

2018 ◽

Vol 159 ◽

pp. 255-266 ◽

Author(s):

Shuxia Wang ◽

Yu Fang ◽

Huan Wang ◽

Hang Gao ◽

Guohua Jiang ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Biological Evaluation ◽

Imaging Agents ◽

Α7 Nicotinic Acetylcholine Receptor ◽

Nicotinic Acetylcholine ◽

Design Synthesis ◽

Pet Ct ◽

Synthesis And Biological Evaluation

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Nicotinic Acetylcholine Receptor Ligands, Cognitive Function, and Preclinical Approaches to Drug Discovery

Nicotine & Tobacco Research ◽

10.1093/ntr/nty166 ◽

2018 ◽

Vol 21 (3) ◽

pp. 383-394 ◽

Author(s):

Alvin V Terry ◽

Patrick M Callahan

Keyword(s):

Drug Discovery ◽

Cognitive Function ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Receptor Ligands ◽

Nicotinic Acetylcholine

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Effects of nicotinic acetylcholine receptor ligands on behavioral vigilance in rats

Psychopharmacology ◽

10.1007/bf02245840 ◽

1995 ◽

Vol 118 (2) ◽

pp. 195-205 ◽

Author(s):

J. Turchi ◽

L. A. Holley ◽

M. Sarter

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Receptor Ligands ◽

Nicotinic Acetylcholine

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Stimulation of dopamine release by nicotinic acetylcholine receptor ligands in rat brain slices correlates with the profile of high, but not low, sensitivity α4β2 subunit combination

Biochemical Pharmacology ◽

10.1016/j.bcp.2009.06.024 ◽

2009 ◽

Vol 78 (7) ◽

pp. 844-851 ◽

Author(s):

David J. Anderson ◽

John Malysz ◽

Jens Halvard Grønlien ◽

Rachid El Kouhen ◽

Monika Håkerud ◽

...

Keyword(s):

Rat Brain ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Dopamine Release ◽

Brain Slices ◽

Receptor Ligands ◽

Nicotinic Acetylcholine ◽

Subunit Combination ◽

Low Sensitivity ◽

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Neuronal nicotinic acetylcholine receptor ligands as potential analgesics

Expert Opinion on Therapeutic Patents ◽

10.1517/13543776.13.7.1003 ◽

2003 ◽

Vol 13 (7) ◽

pp. 1003-1021 ◽

Author(s):

William H Bunnelle ◽

Michael W Decker

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Neuronal Nicotinic Acetylcholine Receptor ◽

Receptor Ligands ◽

Nicotinic Acetylcholine

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The α7 nicotinic acetylcholine receptor ligands methyllycaconitine, NS6740 and GTS-21 reduce lipopolysaccharide-induced TNF-α release from microglia

Journal of Neuroimmunology ◽

10.1016/j.jneuroim.2012.07.006 ◽

2012 ◽

Vol 251 (1-2) ◽

pp. 65-72 ◽

Author(s):

Morten S. Thomsen ◽

Jens D. Mikkelsen

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Receptor Ligands ◽

Α7 Nicotinic Acetylcholine Receptor ◽

Nicotinic Acetylcholine ◽

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Comparison of binding and functional activity profiles for a set of nicotinic acetylcholine receptor ligands across multiple α6* expression systems

Biochemical Pharmacology ◽

10.1016/j.bcp.2011.07.006 ◽

2011 ◽

Vol 82 (8) ◽

pp. 1024

Author(s):

Scott R. Breining ◽

Christopher Hepler ◽

Paul Whiteaker ◽

Maryka Quik ◽

Sharon R. Grady ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Functional Activity ◽

Expression Systems ◽

Receptor Ligands ◽

Nicotinic Acetylcholine

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Design, Synthesis, and Biological Evaluation of Erythrina Alkaloid Analogues as Neuronal Nicotinic Acetylcholine Receptor Antagonists

Journal of Medicinal Chemistry ◽

10.1021/jm4013592 ◽

2013 ◽

Vol 56 (23) ◽

pp. 9673-9682 ◽

Author(s):

François Crestey ◽

Anders A. Jensen ◽

Morten Borch ◽

Jesper Tobias Andreasen ◽

Jacob Andersen ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Biological Evaluation ◽

Neuronal Nicotinic Acetylcholine Receptor ◽

Receptor Antagonists ◽

Nicotinic Acetylcholine ◽

Design Synthesis ◽

Synthesis And Biological Evaluation ◽

Erythrina Alkaloid

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Discovery of nicotinic acetylcholine receptor ligands in the chemical universe database GDB-13

Biochemical Pharmacology ◽

10.1016/j.bcp.2011.07.014 ◽

2011 ◽

Vol 82 (8) ◽

pp. 1027

Author(s):

L.C. Blum ◽

R. van Deursen ◽

J. Bürgi ◽

J.-L. Reymond ◽

M. Maver ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Receptor Ligands ◽

Nicotinic Acetylcholine

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