Design, Synthesis, and Evaluation of Novel Imidazo[1,2-a][1,3,5]triazines and Their Derivatives as Focal Adhesion Kinase Inhibitors with Antitumor Activity

2014 ◽  
Vol 58 (1) ◽  
pp. 237-251 ◽  
Author(s):  
Pascal Dao ◽  
Nikaia Smith ◽  
Céline Tomkiewicz-Raulet ◽  
Expédite Yen-Pon ◽  
Marta Camacho-Artacho ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Focal Adhesion Kinase ◽  
Focal Adhesion ◽  
Kinase Inhibitors ◽  
Design Synthesis

Focal adhesion kinase inhibitors in the treatment of metastatic cancer: a patent review

2014 ◽  
Vol 24 (10) ◽  
pp. 1077-1100 ◽  
Author(s):  
Ekambaram Shanthi ◽  
Mudeenahally H Krishna ◽  
Gubbi M Arunesh ◽  
K Venkateswara Reddy ◽  
Jegatheesan Sooriya Kumar ◽  
...  
Keyword(s):  
Focal Adhesion Kinase ◽  
Focal Adhesion ◽  
Kinase Inhibitors ◽  
Metastatic Cancer ◽  
Patent Review

scholarly journals Focal adhesion kinase inhibitors, a heavy punch to cancer

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Yueling Wu ◽  
Ning Li ◽  
Chengfeng Ye ◽  
Xingmei Jiang ◽  
Hui Luo ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Focal Adhesion Kinase ◽  
Focal Adhesion ◽  
Kinase Inhibitors ◽  
Early Stage ◽  
Perspective View ◽  
Combination Strategy ◽  
Cancer Cell Growth ◽  
Cancer Types ◽  
Chemotherapy Strategy

AbstractKinases are the ideal druggable targets for diseases and especially were highlighted on cancer therapy. Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase and its aberrant signaling extensively implicates in the progression of most cancer types, involving in cancer cell growth, adhesion, migration, and tumor microenvironment (TME) remodeling. FAK is commonly overexpressed and activated in a variety of cancers and plays as a targetable kinase in cancer therapy. FAK inhibitors already exhibited promising performance in preclinical and early-stage clinical trials. Moreover, substantial evidence has implied that targeting FAK is more effective in combination strategy, thereby reversing the failure of chemotherapies or targeted therapies in solid tumors. In the current review, we summarized the drug development progress, chemotherapy strategy, and perspective view for FAK inhibitors.

Fragment-Based Discovery of New Highly Substituted 1H-Pyrrolo[2,3-b]- and 3H-Imidazolo[4,5-b]-Pyridines as Focal Adhesion Kinase Inhibitors

2013 ◽  
Vol 56 (3) ◽  
pp. 1160-1170 ◽  
Author(s):  
Timo Heinrich ◽  
Jeyaprakashnarayanan Seenisamy ◽  
Lourdusamy Emmanuvel ◽  
Santosh S. Kulkarni ◽  
Jörg Bomke ◽  
...  
Keyword(s):  
Focal Adhesion Kinase ◽  
Focal Adhesion ◽  
Kinase Inhibitors

Abstract A86: Design, synthesis, and SAR of focal adhesion kinase (FAK) inhibitors

2009 ◽  
Author(s):  
Walter Gregory Roberts ◽  
Martin Berliner ◽  
Kevin Coleman ◽  
Erling Emerson ◽  
Matt Griffor ◽  
...  
Keyword(s):  
Focal Adhesion Kinase ◽  
Focal Adhesion ◽  
Design Synthesis

Fragment-based discovery of focal adhesion kinase inhibitors

2013 ◽  
Vol 23 (19) ◽  
pp. 5401-5409 ◽  
Author(s):  
Ulrich Grädler ◽  
Jörg Bomke ◽  
Djordje Musil ◽  
Verena Dresing ◽  
Martin Lehmann ◽  
...  
Keyword(s):  
Focal Adhesion Kinase ◽  
Focal Adhesion ◽  
Kinase Inhibitors
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