Synthesis and Structure–Activity Relationships of Ring-Opened 17-Hydroxywortmannins: Potent Phosphoinositide 3-Kinase Inhibitors with Improved Properties and Anticancer Efficacy

2008 ◽  
Vol 51 (5) ◽  
pp. 1319-1323 ◽  
Author(s):  
Arie Zask ◽  
Joshua Kaplan ◽  
Lourdes Toral-Barza ◽  
Irwin Hollander ◽  
Mairead Young ◽  
...  
Keyword(s):  
Kinase Inhibitors ◽  
Anticancer Efficacy ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Phosphoinositide 3 Kinase

Structure−Activity Relationships for a Novel Series of Pyrido[2,3-d]pyrimidine Tyrosine Kinase Inhibitors

1997 ◽  
Vol 40 (15) ◽  
pp. 2296-2303 ◽  
Author(s):  
James M. Hamby ◽  
Cleo J. C. Connolly ◽  
Mel C. Schroeder ◽  
R. Thomas Winters ◽  
H. D. Hollis Showalter ◽  
...  
Keyword(s):  
Tyrosine Kinase ◽  
Tyrosine Kinase Inhibitors ◽  
Kinase Inhibitors ◽  
Structure Activity Relationships ◽  
Structure Activity

Synthesis and Structure—Activity Relationships of 5-Heteroatom-Substituted Pyridopyrimidines as Adenosine Kinase Inhibitors.

ChemInform ◽  
2003 ◽  
Vol 34 (31) ◽  
Author(s):  
Gregory A. Gfesser ◽  
Erol K. Bayburt ◽  
Marlon Cowart ◽  
Stanley DiDomenico ◽  
Arthur Gomtsyan ◽  
...  
Keyword(s):  
Kinase Inhibitors ◽  
Adenosine Kinase ◽  
Structure Activity Relationships ◽  
Structure Activity

4-Amino-5-aryl-6-arylethynylpyrimidines: Structure–activity relationships of non-nucleoside adenosine kinase inhibitors

2007 ◽  
Vol 15 (4) ◽  
pp. 1586-1605 ◽  
Author(s):  
Mark A. Matulenko ◽  
Ernest S. Paight ◽  
Robin R. Frey ◽  
Arthur Gomtsyan ◽  
Stanley DiDomenico ◽  
...  
Keyword(s):  
Kinase Inhibitors ◽  
Adenosine Kinase ◽  
Structure Activity Relationships ◽  
Structure Activity

Cell Division Cycle 7 Kinase Inhibitors: 1H-Pyrrolo[2,3-b]pyridines, Synthesis and Structure−Activity Relationships

2009 ◽  
Vol 52 (14) ◽  
pp. 4380-4390 ◽  
Author(s):  
Antonella Ermoli ◽  
Alberto Bargiotti ◽  
Maria Gabriella Brasca ◽  
Antonella Ciavolella ◽  
Nicoletta Colombo ◽  
...  
Keyword(s):  
Cell Division ◽  
Kinase Inhibitors ◽  
Cell Division Cycle ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Cell Division Cycle 7

Cdc7 Kinase Inhibitors: Pyrrolopyridinones as Potential Antitumor Agents. 1. Synthesis and Structure–Activity Relationships

2008 ◽  
Vol 51 (3) ◽  
pp. 487-501 ◽  
Author(s):  
Ermes Vanotti ◽  
Raffaella Amici ◽  
Alberto Bargiotti ◽  
Jens Berthelsen ◽  
Roberta Bosotti ◽  
...  
Keyword(s):  
Kinase Inhibitors ◽  
Antitumor Agents ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Cdc7 Kinase ◽  
Potential Antitumor

scholarly journals Structure activity relationships of chrysoeriol and analogs as dual c‑Met and VEGFR2 tyrosine kinase inhibitors

2018 ◽  
Author(s):  
Shuang Lai ◽  
Jun‑Ning Chen ◽  
Han‑Wei Huang ◽  
Xiang‑Yu Zhang ◽  
Hai‑Lun Jiang ◽  
...  
Keyword(s):  
Tyrosine Kinase ◽  
Tyrosine Kinase Inhibitors ◽  
Kinase Inhibitors ◽  
Structure Activity Relationships ◽  
Structure Activity

Synthesis and structure–activity relationships of 1,2,4-triazolo[1,5-a]pyrimidin-7(3H)-ones as novel series of potent β isoform selective phosphatidylinositol 3-kinase inhibitors

2012 ◽  
Vol 22 (9) ◽  
pp. 3198-3202 ◽  
Author(s):  
Robert M. Sanchez ◽  
Karl Erhard ◽  
Mary Ann Hardwicke ◽  
Hong Lin ◽  
Jeanelle McSurdy-Freed ◽  
...  
Keyword(s):  
Kinase Inhibitors ◽  
Phosphatidylinositol 3 Kinase ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Phosphatidylinositol 3
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