Design, Structure−Activity Relationships and in Vivo Characterization of 4-Amino-3-benzimidazol-2-ylhydroquinolin-2-ones: A Novel Class of Receptor Tyrosine Kinase Inhibitors

Paul A. Renhowe; Sabina Pecchi; Cynthia M. Shafer; Timothy D. Machajewski; Elisa M. Jazan; Clarke Taylor; William Antonios-McCrea; Christopher M. McBride; Kelly Frazier; Marion Wiesmann; Gena R. Lapointe; Paul H. Feucht; Robert L. Warne; Carla C. Heise; Daniel Menezes; Kimberly Aardalen; Helen Ye; Molly He; Vincent Le; Jayesh Vora; Johanna M. Jansen; Mary Ellen Wernette-Hammond; Alex L. Harris

doi:10.1021/jm800790t

Design, Structure−Activity Relationships and in Vivo Characterization of 4-Amino-3-benzimidazol-2-ylhydroquinolin-2-ones: A Novel Class of Receptor Tyrosine Kinase Inhibitors

Journal of Medicinal Chemistry ◽

10.1021/jm800790t ◽

2009 ◽

Vol 52 (2) ◽

pp. 278-292 ◽

Cited By ~ 94

Author(s):

Paul A. Renhowe ◽

Sabina Pecchi ◽

Cynthia M. Shafer ◽

Timothy D. Machajewski ◽

Elisa M. Jazan ◽

...

Keyword(s):

Tyrosine Kinase ◽

Tyrosine Kinase Inhibitors ◽

Receptor Tyrosine Kinase ◽

Kinase Inhibitors ◽

Structure Activity ◽

Design Structure ◽

In Vivo Characterization ◽

Receptor Tyrosine Kinase Inhibitors

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Novel 4-anilinoquinazolines with C-6 carbon-linked side chains: Synthesis and structure–activity relationship of a series of potent, orally active, EGF receptor tyrosine kinase inhibitors

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2006.02.025 ◽

2006 ◽

Vol 16 (10) ◽

pp. 2672-2676 ◽

Cited By ~ 20

Author(s):

Laurent F.A. Hennequin ◽

Peter Ballard ◽

F. Tom Boyle ◽

Bénédicte Delouvrié ◽

Rebecca P.A. Ellston ◽

...

Keyword(s):

Tyrosine Kinase ◽

Tyrosine Kinase Inhibitors ◽

Receptor Tyrosine Kinase ◽

Kinase Inhibitors ◽

Egf Receptor ◽

Activity Relationship ◽

Structure Activity ◽

Relationship Of ◽

Orally Active ◽

Receptor Tyrosine Kinase Inhibitors

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Discovery and characterization of potent and selective AXL receptor tyrosine kinase inhibitors for cancer therapy

European Journal of Cancer ◽

10.1016/s0959-8049(20)31175-8 ◽

2020 ◽

Vol 138 ◽

pp. S38-S39

Author(s):

D. Miles ◽

Y. Chen ◽

S.L. Paprcka ◽

C.N. Foley ◽

R. Grange ◽

...

Keyword(s):

Cancer Therapy ◽

Tyrosine Kinase ◽

Tyrosine Kinase Inhibitors ◽

Receptor Tyrosine Kinase ◽

Kinase Inhibitors ◽

Axl Receptor Tyrosine Kinase ◽

Receptor Tyrosine Kinase Inhibitors

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Novel 4-Anilinoquinazolines with C-7 Basic Side Chains: Design and Structure Activity Relationship of a Series of Potent, Orally Active, VEGF Receptor Tyrosine Kinase Inhibitors

Journal of Medicinal Chemistry ◽

10.1021/jm011022e ◽

2002 ◽

Vol 45 (6) ◽

pp. 1300-1312 ◽

Cited By ~ 205

Author(s):

Laurent F. Hennequin ◽

Elaine S. E. Stokes ◽

Andrew P. Thomas ◽

Craig Johnstone ◽

Patrick A. Plé ◽

...

Keyword(s):

Tyrosine Kinase ◽

Tyrosine Kinase Inhibitors ◽

Receptor Tyrosine Kinase ◽

Kinase Inhibitors ◽

Activity Relationship ◽

Vegf Receptor ◽

Structure Activity ◽

Relationship Of ◽

Orally Active ◽

Receptor Tyrosine Kinase Inhibitors

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Abstract A132: Deciphering the molecular regulators of tumor resistance to VEGF-receptor tyrosine kinase inhibitors via in vivo genome-wide RNAi screen

10.1158/1535-7163.targ-17-a132 ◽

2018 ◽

Author(s):

Azadeh Fahim Golestaneh ◽

Maoyun Sun ◽

Christian Schwager ◽

Zili Tang ◽

Lili Ma ◽

...

Keyword(s):

Tyrosine Kinase ◽

Tyrosine Kinase Inhibitors ◽

Receptor Tyrosine Kinase ◽

Kinase Inhibitors ◽

Rnai Screen ◽

Vegf Receptor ◽

Tumor Resistance ◽

Genome Wide ◽

Receptor Tyrosine Kinase Inhibitors

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Design and Structure−Activity Relationship of a New Class of Potent VEGF Receptor Tyrosine Kinase Inhibitors

Journal of Medicinal Chemistry ◽

10.1021/jm990345w ◽

1999 ◽

Vol 42 (26) ◽

pp. 5369-5389 ◽

Cited By ~ 161

Author(s):

Laurent F. Hennequin ◽

Andrew P. Thomas ◽

Craig Johnstone ◽

Elaine S. E. Stokes ◽

Patrick A. Plé ◽

...

Keyword(s):

Tyrosine Kinase ◽

Tyrosine Kinase Inhibitors ◽

Receptor Tyrosine Kinase ◽

Kinase Inhibitors ◽

Activity Relationship ◽

Vegf Receptor ◽

New Class ◽

Structure Activity ◽

Relationship Of ◽

Receptor Tyrosine Kinase Inhibitors

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Synthesis and structure–activity relationship of 6-arylureido-3-pyrrol-2-ylmethylideneindolin-2-one derivatives as potent receptor tyrosine kinase inhibitors

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2010.05.021 ◽

2010 ◽

Vol 18 (13) ◽

pp. 4674-4686 ◽

Cited By ~ 16

Author(s):

Rahul R. Khanwelkar ◽

Grace Shiahuy Chen ◽

Hsiao-Chun Wang ◽

Chao-Wu Yu ◽

Chiung-Hua Huang ◽

...

Keyword(s):

Tyrosine Kinase ◽

Tyrosine Kinase Inhibitors ◽

Receptor Tyrosine Kinase ◽

Kinase Inhibitors ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Structure Activity ◽

Relationship Of ◽

Receptor Tyrosine Kinase Inhibitors

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DoMCoSAR: A Novel Approach for Establishing the Docking Mode That Is Consistent with the Structure−Activity Relationship. Application to HIV-1 Protease Inhibitors and VEGF Receptor Tyrosine Kinase Inhibitors

Journal of Medicinal Chemistry ◽

10.1021/jm990609e ◽

2000 ◽

Vol 43 (16) ◽

pp. 3020-3032 ◽

Cited By ~ 46

Author(s):

Michal Vieth ◽

David J. Cummins

Keyword(s):

Tyrosine Kinase ◽

Protease Inhibitors ◽

Tyrosine Kinase Inhibitors ◽

Receptor Tyrosine Kinase ◽

Kinase Inhibitors ◽

Vegf Receptor ◽

Structure Activity ◽

Novel Approach ◽

Hiv 1 ◽

Receptor Tyrosine Kinase Inhibitors

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N4-(3-Bromophenyl)-7-(substituted benzyl) pyrrolo[2,3-d]pyrimidines as potent multiple receptor tyrosine kinase inhibitors: Design, synthesis, and in vivo evaluation

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2012.01.029 ◽

2012 ◽

Vol 20 (7) ◽

pp. 2444-2454 ◽

Cited By ~ 11

Author(s):

Aleem Gangjee ◽

Nilesh Zaware ◽

Sudhir Raghavan ◽

Jie Yang ◽

Jessica E. Thorpe ◽

...

Keyword(s):

Tyrosine Kinase ◽

Tyrosine Kinase Inhibitors ◽

Receptor Tyrosine Kinase ◽

Kinase Inhibitors ◽

In Vivo Evaluation ◽

Design Synthesis ◽

Multiple Receptor ◽

Receptor Tyrosine Kinase Inhibitors

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Novel Potent Orally Active Multitargeted Receptor Tyrosine Kinase Inhibitors: Synthesis, Structure−Activity Relationships, and Antitumor Activities of 2-Indolinone Derivatives

Journal of Medicinal Chemistry ◽

10.1021/jm101036c ◽

2010 ◽

Vol 53 (22) ◽

pp. 8140-8149 ◽

Cited By ~ 33

Author(s):

Peng Cho Tang ◽

Yi Dong Su ◽

Jun Feng ◽

Jian Hong Fu ◽

Jiang Liang Yang ◽

...

Keyword(s):

Tyrosine Kinase ◽

Tyrosine Kinase Inhibitors ◽

Receptor Tyrosine Kinase ◽

Kinase Inhibitors ◽

Antitumor Activities ◽

Structure Activity Relationships ◽

Structure Activity ◽

Orally Active ◽

Receptor Tyrosine Kinase Inhibitors

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ChemInform Abstract: Design and Structure-Activity Relationship of a New Class of Potent VEGF Receptor Tyrosine Kinase Inhibitors.

ChemInform ◽

10.1002/chin.200013120 ◽

2010 ◽

Vol 31 (13) ◽

pp. no-no

Author(s):

Laurent F. Hennequin ◽

et al. et al.

Keyword(s):

Tyrosine Kinase ◽

Tyrosine Kinase Inhibitors ◽

Receptor Tyrosine Kinase ◽

Kinase Inhibitors ◽

Activity Relationship ◽

Vegf Receptor ◽

New Class ◽

Structure Activity ◽

Relationship Of ◽

Receptor Tyrosine Kinase Inhibitors

Download Full-text