DoMCoSAR:  A Novel Approach for Establishing the Docking Mode That Is Consistent with the Structure−Activity Relationship. Application to HIV-1 Protease Inhibitors and VEGF Receptor Tyrosine Kinase Inhibitors

Kinase Inhibitors ◽

Vegf Receptor ◽

Structure Activity ◽

Novel Approach ◽

Hiv 1 ◽

Novel 4-Anilinoquinazolines with C-7 Basic Side Chains: Design and Structure Activity Relationship of a Series of Potent, Orally Active, VEGF Receptor Tyrosine Kinase Inhibitors

Journal of Medicinal Chemistry ◽

10.1021/jm011022e ◽

2002 ◽

Vol 45 (6) ◽

pp. 1300-1312 ◽

Cited By ~ 205

Author(s):

Laurent F. Hennequin ◽

Elaine S. E. Stokes ◽

Andrew P. Thomas ◽

Craig Johnstone ◽

Patrick A. Plé ◽

...

Keyword(s):

Tyrosine Kinase ◽

Kinase Inhibitors ◽

Activity Relationship ◽

Vegf Receptor ◽

Structure Activity ◽

Relationship Of ◽

Orally Active ◽

Design and Structure−Activity Relationship of a New Class of Potent VEGF Receptor Tyrosine Kinase Inhibitors

Journal of Medicinal Chemistry ◽

10.1021/jm990345w ◽

1999 ◽

Vol 42 (26) ◽

pp. 5369-5389 ◽

Cited By ~ 161

Author(s):

Laurent F. Hennequin ◽

Andrew P. Thomas ◽

Craig Johnstone ◽

Elaine S. E. Stokes ◽

Patrick A. Plé ◽

...

Keyword(s):

Tyrosine Kinase ◽

Kinase Inhibitors ◽

Activity Relationship ◽

Vegf Receptor ◽

New Class ◽

Structure Activity ◽

Relationship Of ◽

ChemInform Abstract: Design and Structure-Activity Relationship of a New Class of Potent VEGF Receptor Tyrosine Kinase Inhibitors.

ChemInform ◽

10.1002/chin.200013120 ◽

2010 ◽

Vol 31 (13) ◽

pp. no-no

Author(s):

Laurent F. Hennequin ◽

et al. et al.

Keyword(s):

Tyrosine Kinase ◽

Kinase Inhibitors ◽

Activity Relationship ◽

Vegf Receptor ◽

New Class ◽

Structure Activity ◽

Relationship Of ◽

Novel 4-anilinoquinazolines with C-6 carbon-linked side chains: Synthesis and structure–activity relationship of a series of potent, orally active, EGF receptor tyrosine kinase inhibitors

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2006.02.025 ◽

2006 ◽

Vol 16 (10) ◽

pp. 2672-2676 ◽

Cited By ~ 20

Author(s):

Laurent F.A. Hennequin ◽

Peter Ballard ◽

F. Tom Boyle ◽

Bénédicte Delouvrié ◽

Rebecca P.A. Ellston ◽

...

Keyword(s):

Tyrosine Kinase ◽

Kinase Inhibitors ◽

Egf Receptor ◽

Activity Relationship ◽

Structure Activity ◽

Relationship Of ◽

Orally Active ◽

Abstract A132: Deciphering the molecular regulators of tumor resistance to VEGF-receptor tyrosine kinase inhibitors via in vivo genome-wide RNAi screen

10.1158/1535-7163.targ-17-a132 ◽

2018 ◽

Author(s):

Azadeh Fahim Golestaneh ◽

Maoyun Sun ◽

Christian Schwager ◽

Zili Tang ◽

Lili Ma ◽

...

Keyword(s):

Tyrosine Kinase ◽

Kinase Inhibitors ◽

Rnai Screen ◽

Vegf Receptor ◽

Tumor Resistance ◽

Genome Wide ◽

Synthesis and structure–activity relationship of 6-arylureido-3-pyrrol-2-ylmethylideneindolin-2-one derivatives as potent receptor tyrosine kinase inhibitors

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2010.05.021 ◽

2010 ◽

Vol 18 (13) ◽

pp. 4674-4686 ◽

Cited By ~ 16

Author(s):

Rahul R. Khanwelkar ◽

Grace Shiahuy Chen ◽

Hsiao-Chun Wang ◽

Chao-Wu Yu ◽

Chiung-Hua Huang ◽

...

Keyword(s):

Tyrosine Kinase ◽

Kinase Inhibitors ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Structure Activity ◽

Relationship Of ◽

Bevacizumab salvage therapy following progression in high-grade glioma patients treated with VEGF receptor tyrosine kinase inhibitors

Neuro-Oncology ◽

10.1093/neuonc/nop073 ◽

2010 ◽

Vol 12 (6) ◽

pp. 603-607 ◽

Cited By ~ 37

Author(s):

B. J. Scott ◽

E. C. Quant ◽

M. B. McNamara ◽

P. A. Ryg ◽

T. T. Batchelor ◽

...

Keyword(s):

Tyrosine Kinase ◽

Salvage Therapy ◽

Kinase Inhibitors ◽

High Grade Glioma ◽

Vegf Receptor ◽

High Grade ◽

Risk of thyroid dysfunction in patients with solid tumors treated with VEGF receptor tyrosine kinase inhibitors: a critical literature review and meta analysis

Expert Review of Anticancer Therapy ◽

10.1586/14737140.2014.929501 ◽

2014 ◽

Vol 14 (9) ◽

pp. 1063-1073 ◽

Cited By ~ 18

Author(s):

Omar Abdel-Rahman ◽

Mona Fouad

Keyword(s):

Literature Review ◽

Tyrosine Kinase ◽

Thyroid Dysfunction ◽

Kinase Inhibitors ◽

Meta Analysis ◽

Vegf Receptor ◽

Receptor Tyrosine Kinase Inhibitors ◽

Critical Literature

Faculty Opinions recommendation of Bevacizumab salvage therapy following progression in high-grade glioma patients treated with VEGF receptor tyrosine kinase inhibitors.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.2885956.2554054 ◽

2010 ◽

Author(s):

David Schiff ◽

Roger Abounader

Keyword(s):

Tyrosine Kinase ◽

Salvage Therapy ◽

Kinase Inhibitors ◽

High Grade Glioma ◽

Vegf Receptor ◽

High Grade ◽

Clinical trials of VEGF receptor tyrosine kinase inhibitors in pancreatic cancer

Expert Opinion on Investigational Drugs ◽

10.1517/13543784.16.4.467 ◽

2007 ◽

Vol 16 (4) ◽

pp. 467-476 ◽

Cited By ~ 14

Author(s):

Elwyn Cabebe ◽

George A Fisher

Keyword(s):

Pancreatic Cancer ◽

Clinical Trials ◽

Tyrosine Kinase ◽

Kinase Inhibitors ◽

Vegf Receptor ◽