Indolobenzazepin-7-ones and 6-, 8-, and 9-Membered Ring Derivatives as Tubulin Polymerization Inhibitors: Synthesis and Structure−Activity Relationship Studies

2009 ◽  
Vol 52 (19) ◽  
pp. 5916-5925 ◽  
Author(s):  
Aurélien Putey ◽  
Florence Popowycz ◽  
Quoc-Tuan Do ◽  
Philippe Bernard ◽  
Sandeep K. Talapatra ◽  
...  
Keyword(s):  
Structure Activity Relationship ◽  
Membered Ring ◽  
Activity Relationship ◽  
Tubulin Polymerization ◽  
Structure Activity ◽  
Tubulin Polymerization Inhibitors

Identification of a Novel Indoleamine 2,3-Dioxygenase Inhibitor Bearing an Eight-Membered Ring Fused Indole Scaffold and Its Structure-Activity Relationship

Heterocycles ◽  
2021 ◽  
Vol 103 (1) ◽  
pp. 331
Author(s):  
Shinsuke Inuki ◽  
Hiroaki Ohno ◽  
Ayuta Yamaguchi ◽  
Katsumi Ohta ◽  
Shinya Oishi ◽  
...  
Keyword(s):  
Structure Activity Relationship ◽  
Membered Ring ◽  
Activity Relationship ◽  
Indoleamine 2,3 Dioxygenase ◽  
Structure Activity

scholarly journals Arylidene indanone scaffold: medicinal chemistry and structure–activity relationship view

RSC Advances ◽  
2017 ◽  
Vol 7 (15) ◽  
pp. 9357-9372 ◽  
Author(s):  
José C. J. M. D. S. Menezes
Keyword(s):  
Medicinal Chemistry ◽  
Structure Activity Relationship ◽  
Membered Ring ◽  
Activity Relationship ◽  
Unsaturated Ketone ◽  
Structure Activity

Arylidene indanone (AI) scaffolds are considered as the rigid cousins of chalcones, incorporating the α,β-unsaturated ketone system of chalcones forming a cyclic 5 membered ring.

scholarly journals Skin Damages—Structure Activity Relationship of Benzimidazole Derivatives Bearing a 5-Membered Ring System

Molecules ◽  
2020 ◽  
Vol 25 (18) ◽  
pp. 4324
Author(s):  
Ernestine Nicaise Djuidje ◽  
Elisa Durini ◽  
Sabrina Sciabica ◽  
Elena Serra ◽  
Jan Balzarini ◽  
...  
Keyword(s):  
Structure Activity Relationship ◽  
Membered Ring ◽  
Activity Relationship ◽  
Benzimidazole Derivatives ◽  
Potential Candidate ◽  
Benzimidazole Ring ◽  
Multifunctional Compounds ◽  
Structure Activity ◽  
Relationship Of

In the search for scaffolds for multifunctional compounds we investigated the structure activity relationship of a class of benzimidazole derivatives bearing 5-membered ring. The newly synthesized and the already known compounds were divided into three classes that present different substituent at 5 position of the benzimidazole ring (-H, -COOH or –SO3H) and different heterocycle at position 2 (thiophene, furan or pyrrole). All the derivatives were synthesized and tested to determine their photoprotective profile against UV rays, in vitro antioxidant capacity against different radicals (DPPH and FRAP test), antifungal inhibitory activity (dermatophytes and Candida albicans), antiviral and antiproliferative activity. A Structure-Activity Relationship study indicated compound 10, bearing a pyrrole heterocycle on the benzimidazole ring, as the best multifunctional derivative of the series and as potential candidate for the development of drugs especially in case of melanoma.

Structure-activity relationship of (-) mammea A/BB derivatives against Leishmania amazonensis

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
MA Brenzan ◽  
CV Nakamura ◽  
BPD Filho ◽  
T Ueda-Nakamura ◽  
MCM Young ◽  
...  
Keyword(s):  
Structure Activity Relationship ◽  
Leishmania Amazonensis ◽  
Activity Relationship ◽  
Structure Activity ◽  
Relationship Of

Structure Activity Relationship of Kahalalide F and its Analogs Against Fusarium Spp

Planta Medica ◽  
2008 ◽  
Vol 74 (03) ◽  
Author(s):  
N Kasanah ◽  
AG Shilabin ◽  
DE Wedge ◽  
MT Hamann
Keyword(s):  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Fusarium Spp ◽  
Structure Activity ◽  
Kahalalide F ◽  
Relationship Of
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