Development of triazolothiadiazine derivatives as highly potent tubulin polymerization inhibitors: Structure-activity relationship, in vitro and in vivo study

2020 ◽  
Vol 208 ◽  
pp. 112847
Author(s):  
Weifeng Ma ◽  
Peng Chen ◽  
Xiansen Huo ◽  
Yufeng Ma ◽  
Yanhong Li ◽  
...  
Keyword(s):  
Structure Activity Relationship ◽  
In Vivo Study ◽  
Activity Relationship ◽  
Tubulin Polymerization ◽  
Structure Activity ◽  
Tubulin Polymerization Inhibitors

The selective 5-HT2A receptor agonist 25CN-NBOH: Structure-activity relationship, in vivo pharmacology, and in vitro and ex vivo binding characteristics of [3H]25CN-NBOH

2020 ◽  
Vol 177 ◽  
pp. 113979 ◽  
Author(s):  
Anders A. Jensen ◽  
Adam L. Halberstadt ◽  
Emil Märcher-Rørsted ◽  
Anna U. Odland ◽  
Muhammad Chatha ◽  
...  
Keyword(s):  
Receptor Agonist ◽  
Ex Vivo ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Binding Characteristics ◽  
Structure Activity

Radiochemical Investigations of99mTc−N3S-X-BBN[7−14]NH2:  An in Vitro/in Vivo Structure−Activity Relationship Study Where X = 0-, 3-, 5-, 8-, and 11-Carbon Tethering Moieties

2003 ◽  
Vol 14 (1) ◽  
pp. 93-102 ◽  
Author(s):  
C. Jeffrey Smith ◽  
Hariprasad Gali ◽  
Gary L. Sieckman ◽  
Chris Higginbotham ◽  
Wynn A. Volkert ◽  
...  
Keyword(s):  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Structure Activity ◽  
Relationship Study

Discovery and Structure−Activity Relationship of Antagonists of B-Cell Lymphoma 2 Family Proteins with Chemopotentiation Activity in Vitro and in Vivo

2006 ◽  
Vol 49 (3) ◽  
pp. 1165-1181 ◽  
Author(s):  
Michael D. Wendt ◽  
Wang Shen ◽  
Aaron Kunzer ◽  
William J. McClellan ◽  
Milan Bruncko ◽  
...  
Keyword(s):  
B Cell ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Structure Activity ◽  
Relationship Of

Indolobenzazepin-7-ones and 6-, 8-, and 9-Membered Ring Derivatives as Tubulin Polymerization Inhibitors: Synthesis and Structure−Activity Relationship Studies

2009 ◽  
Vol 52 (19) ◽  
pp. 5916-5925 ◽  
Author(s):  
Aurélien Putey ◽  
Florence Popowycz ◽  
Quoc-Tuan Do ◽  
Philippe Bernard ◽  
Sandeep K. Talapatra ◽  
...  
Keyword(s):  
Structure Activity Relationship ◽  
Membered Ring ◽  
Activity Relationship ◽  
Tubulin Polymerization ◽  
Structure Activity ◽  
Tubulin Polymerization Inhibitors
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