Improved P1/P1‘ Substituents for Cyclic Urea Based HIV-1 Protease Inhibitors:  Synthesis, Structure−Activity Relationship, and X-ray Crystal Structure Analysis

1997 ◽  
Vol 40 (10) ◽  
pp. 1465-1474 ◽  
Author(s):  
David A. Nugiel ◽  
Kim Jacobs ◽  
Lyndon Cornelius ◽  
Chong-Hwan Chang ◽  
Prabhakar K. Jadhav ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Protease Inhibitors ◽  
Structure Analysis ◽  
Structure Activity Relationship ◽  
Crystal Structure Analysis ◽  
Activity Relationship ◽  
X Ray ◽  
Structure Activity ◽  
Hiv 1

Structure–activity relationship of HIV-1 protease inhibitors containing α-hydroxy-β-amino acids. Detailed study of P 1 site

1999 ◽  
Vol 7 (9) ◽  
pp. 2063-2072 ◽  
Author(s):  
Eiji Takashiro ◽  
Ichiro Hayakawa ◽  
Tamayo Nitta ◽  
Atsushi Kasuya ◽  
Shuichi Miyamoto ◽  
...  
Keyword(s):  
Amino Acids ◽  
Protease Inhibitors ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Structure Activity ◽  
Relationship Of ◽  
Hiv 1

scholarly journals Total Synthesis and Biological Evaluation of Phaeosphaerides

Catalysts ◽  
2018 ◽  
Vol 8 (5) ◽  
pp. 206 ◽  
Author(s):  
Kenichi Kobayashi ◽  
Kosaku Tanaka ◽  
Hiroshi Kogen
Keyword(s):  
Crystal Structure ◽  
Natural Products ◽  
Total Synthesis ◽  
Structure Analysis ◽  
Endophytic Fungus ◽  
Biological Evaluation ◽  
Crystal Structure Analysis ◽  
X Ray ◽  
Structure Activity ◽  
Synthesis And Biological Evaluation

This article reviews studies regarding the total synthesis of phaeosphaerides A and B, nitrogen-containing bicyclic natural products isolated from an endophytic fungus. Numerous synthetic efforts and an X-ray crystal structure analysis of phaeosphaeride A have enabled revision of its originally proposed structure. In addition, a successful protic acid-mediated transformation of phaeosphaeride A to phaeosphaeride B revealed the hypothetical biosynthesis of phaeosphaeride B from phaeosphaeride A. Structure–activity relationship studies of phaeosphaeride derivatives are also discussed.

scholarly journals Structure-Based Design, Synthesis, and Structure−Activity Relationship Studies of HIV-1 Protease Inhibitors Incorporating Phenyloxazolidinones

2010 ◽  
Vol 53 (21) ◽  
pp. 7699-7708 ◽  
Author(s):  
Akbar Ali ◽  
G. S. Kiran Kumar Reddy ◽  
Madhavi N. L. Nalam ◽  
Saima Ghafoor Anjum ◽  
Hong Cao ◽  
...  
Keyword(s):  
Protease Inhibitors ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Design Synthesis ◽  
Structure Activity ◽  
Hiv 1

Nonpeptide Cyclic Cyanoguanidines as HIV-1 Protease Inhibitors:  Synthesis, Structure−Activity Relationships, and X-ray Crystal Structure Studies

1998 ◽  
Vol 41 (9) ◽  
pp. 1446-1455 ◽  
Author(s):  
Prabhakar K. Jadhav ◽  
Francis J. Woerner ◽  
Patrick Y. S. Lam ◽  
C. Nicholas Hodge ◽  
Charles J. Eyermann ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Protease Inhibitors ◽  
X Ray ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Hiv 1
Sign in / Sign up

Export Citation Format

Share Document