Total Synthesis and Biological Evaluation of Phaeosphaerides
Keyword(s):
X Ray
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This article reviews studies regarding the total synthesis of phaeosphaerides A and B, nitrogen-containing bicyclic natural products isolated from an endophytic fungus. Numerous synthetic efforts and an X-ray crystal structure analysis of phaeosphaeride A have enabled revision of its originally proposed structure. In addition, a successful protic acid-mediated transformation of phaeosphaeride A to phaeosphaeride B revealed the hypothetical biosynthesis of phaeosphaeride B from phaeosphaeride A. Structure–activity relationship studies of phaeosphaeride derivatives are also discussed.
1997 ◽
Vol 40
(10)
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pp. 1465-1474
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2005 ◽
Vol 13
(5)
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pp. 1867-1872
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1978 ◽
pp. 1536-1540
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1988 ◽
Vol 184
(3-4)
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pp. 209-219
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Keyword(s):
1976 ◽
pp. 266b-267
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