A General Strategy for the Synthesis of CyclicN-Aryl Hydroxamic Acids via Partial Nitro Group Reduction

2011 ◽  
Vol 76 (9) ◽  
pp. 3484-3497 ◽  
Author(s):  
Laura A. McAllister ◽  
Bruce M. Bechle ◽  
Amy B. Dounay ◽  
Edelweiss Evrard ◽  
Xinmin Gan ◽  
...  
Keyword(s):  
Nitro Group ◽  
Hydroxamic Acids ◽  
General Strategy ◽  
Group Reduction ◽  
Nitro Group Reduction

Development of an Intrinsically Safer Methanolysis/Aromatic Nitro Group Reduction for Step 1 and 2 of Talazoparib Tosylate

2021 ◽  
Author(s):  
David S. B. Daniels ◽  
Robert Crook ◽  
Olivier Dirat ◽  
Steven J. Fussell ◽  
Adam Gymer ◽  
...  
Keyword(s):  
Nitro Group ◽  
Group Reduction ◽  
Aromatic Nitro ◽  
Nitro Group Reduction

Magnetically separable core–shell iron oxide@nickel nanoparticles as high-performance recyclable catalysts for chemoselective reduction of nitroaromatics

2015 ◽  
Vol 5 (1) ◽  
pp. 286-295 ◽  
Author(s):  
Puran Singh Rathore ◽  
Rajesh Patidar ◽  
T. Shripathi ◽  
Sonal Thakore
Keyword(s):  
Iron Oxide ◽  
Nitro Group ◽  
High Performance ◽  
Nickel Nanoparticles ◽  
Core Shell ◽  
Group Reduction ◽  
Recyclable Catalysts ◽  
Magnetically Separable ◽  
Aromatic Nitro ◽  
Nitro Group Reduction

A magnetically separable core–shell iron oxide@nickel nanocatalyst was synthesized, characterized and applied for the aromatic nitro group reduction.

Chemoselective Nitro Group Reduction and Reductive Dechlorination Initiate Degradation of 2-Chloro-5-Nitrophenol by Ralstonia eutropha JMP134

1999 ◽  
Vol 65 (6) ◽  
pp. 2317-2323 ◽  
Author(s):  
Andreas Schenzle ◽  
Hiltrud Lenke ◽  
Jim C. Spain ◽  
Hans-Joachim Knackmuss
Keyword(s):  
Substrate Specificity ◽  
Nitro Group ◽  
Reductive Dechlorination ◽  
Ralstonia Eutropha ◽  
Sole Source ◽  
Group Reduction ◽  
Aromatic Nitro ◽  
Nitrophenol Degradation ◽  
Nitro Group Reduction

ABSTRACT Ralstonia eutropha JMP134 utilizes 2-chloro-5-nitrophenol as a sole source of nitrogen, carbon, and energy. The initial steps for degradation of 2-chloro-5-nitrophenol are analogous to those of 3-nitrophenol degradation in R. eutropha JMP134. 2-Chloro-5-nitrophenol is initially reduced to 2-chloro-5-hydroxylaminophenol, which is subject to an enzymatic Bamberger rearrangement yielding 2-amino-5-chlorohydroquinone. The chlorine of 2-amino-5-chlorohydroquinone is removed by a reductive mechanism, and aminohydroquinone is formed. 2-Chloro-5-nitrophenol and 3-nitrophenol induce the expression of 3-nitrophenol nitroreductase, of 3-hydroxylaminophenol mutase, and of the dechlorinating activity. 3-Nitrophenol nitroreductase catalyzes chemoselective reduction of aromatic nitro groups to hydroxylamino groups in the presence of NADPH. 3-Nitrophenol nitroreductase is active with a variety of mono-, di-, and trinitroaromatic compounds, demonstrating a relaxed substrate specificity of the enzyme. Nitrosobenzene serves as a substrate for the enzyme and is converted faster than nitrobenzene.

Effect of yeast extract on the degradation of organophosphorus insecticides by soil enrichment and bacterial cultures

1989 ◽  
Vol 35 (12) ◽  
pp. 1105-1110 ◽  
Author(s):  
M. Sharmila ◽  
K. Ramanand ◽  
N. Sethunathan
Keyword(s):  
Nitro Group ◽  
Yeast Extract ◽  
Methyl Parathion ◽  
Enrichment Culture ◽  
Bacillus Sp ◽  
Laterite Soil ◽  
Mineral Salts ◽  
Soil Enrichment ◽  
Group Reduction ◽  
Nitro Group Reduction

Soil enrichment cultures were prepared by repeated additions of methyl parathion to flooded alluvial and laterite soils incubated at 35 °C. These cultures were tested for their ability to degrade methyl parathion in a mineral salts medium in the presence and absence of yeast extract. Addition of yeast extract (0.05% w/v) accelerated the degradation of methyl parathion by both enriched cultures. Methyl parathion was degraded by the enrichment culture from alluvial soil essentially by hydrolysis in the absence of yeast extract and by nitro group reduction in its presence. The enrichment culture from laterite soil degraded methyl parathion (by hydrolysis) only in the presence of yeast extract. A Bacillus sp., isolated from laterite soil, degraded methyl parathion essentially by hydrolysis in the presence of a concentration (w/v) of yeast extract of 0.05%, by both hydrolysis and nitro group reduction at 0.1 and 0.25%, and exclusively by nitro group reduction at 0.5%. A similar trend was also noticed with parathion. However, fenitrothion was degraded by Bacillus sp. mainly by hydrolysis at all concentrations of yeast extract, whereas diazinon was not degraded.Key words: organophosphorothioates, biodegradation, yeast extract dependent pathway.

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