Air-Stable Pd(R-allyl)LCl (L= Q-Phos, P(t-Bu)3, etc.) Systems for C–C/N Couplings: Insight into the Structure–Activity Relationship and Catalyst Activation Pathway

2011 ◽  
Vol 76 (19) ◽  
pp. 7918-7932 ◽  
Author(s):  
Carin C. C. Johansson Seechurn ◽  
Sébastien L. Parisel ◽  
Thomas J. Colacot
Keyword(s):  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Catalyst Activation ◽  
Activation Pathway ◽  
Structure Activity ◽  
Insight Into

Therapeutic journey of 2,4-thiazolidinediones as a versatile scaffold: An insight into structure activity relationship

2017 ◽  
Vol 129 ◽  
pp. 218-250 ◽  
Author(s):  
Mohd. Javed Naim ◽  
Md. Jahangir Alam ◽  
Shujauddin Ahmad ◽  
Farah Nawaz ◽  
Neelima Shrivastava ◽  
...  
Keyword(s):  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Structure Activity ◽  
Insight Into

Electrocatalytic CO2 reduction with nickel complexes supported by tunable bipyridyl-N-heterocyclic carbene donors: understanding redox-active macrocycles

2018 ◽  
Vol 54 (27) ◽  
pp. 3351-3354 ◽  
Author(s):  
Xiaojun Su ◽  
Kaitlin M. McCardle ◽  
Julien A. Panetier ◽  
Jonah W. Jurss
Keyword(s):  
Co2 Reduction ◽  
Nickel Complexes ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Structure Activity ◽  
Redox Active ◽  
Reduction Catalysts ◽  
Insight Into

A structure–activity relationship, revealed through a series of nickel-based CO2 reduction catalysts, provides insight into the role of redox-active macrocycles.

scholarly journals Effect of mitonafide analogs on topoisomerase II of Leishmania chagasi.

1996 ◽  
Vol 40 (3) ◽  
pp. 706-709 ◽  
Author(s):  
K M Slunt ◽  
J M Grace ◽  
T L Macdonald ◽  
R D Pearson
Keyword(s):  
Topoisomerase Ii ◽  
Structure Activity Relationship ◽  
Mechanisms Of Action ◽  
Activity Relationship ◽  
Leishmania Chagasi ◽  
Short Term ◽  
Structural Requirements ◽  
Structure Activity ◽  
Selective Targeting ◽  
Insight Into

Mitonafide (4-nitro-benzoisoquinolinedione) and a number of structural analogs were synthesized and studied in order to determine the structural requirements for inhibition of leishmanial nuclear and kinetoplast topoisomerase II and human topoisomerase II. The structure-activity relationship studies with the mitonafide analogs demonstrated that there was selective targeting of leishmanial nuclear topoisomerase II and human topoisomerase II and differential targeting of kinetoplast over nuclear topoisomerase II in the parasite. Mitonafide analogs appeared to have multiple mechanisms of action leading to death of leishmanias, but several compounds that affected kinetoplast but not nuclear topoisomerase II were not cytotoxic as determined by short-term assays. These studies provide new insight into the differential sensitivities of leishmanial nuclear and kinetoplast topoisomerase II to topoisomerase II-targeting drugs.

Effect of physicochemical properties of ammonium-based ionic liquids on CO2 capturing: An insight into structure-activity relationship

2020 ◽  
Vol 510 ◽  
pp. 112484 ◽  
Author(s):  
Sabahat Sardar ◽  
Asad Mumtaz ◽  
Mehwish Taneez ◽  
Masoom Yasinzai ◽  
Muhammad Imran Irshad ◽  
...  
Keyword(s):  
Ionic Liquids ◽  
Physicochemical Properties ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Structure Activity ◽  
Co2 Capturing ◽  
Insight Into
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