Microbial Genomics as a Guide to Drug Discovery and Structural Elucidation:  ECO-02301, a Novel Antifungal Agent, as an Example†

2005 ◽  
Vol 68 (4) ◽  
pp. 493-496 ◽  
Author(s):  
James B. McAlpine ◽  
Brian O. Bachmann ◽  
Mahmood Piraee ◽  
Steve Tremblay ◽  
Anne-Marie Alarco ◽  
...  
Keyword(s):  
Drug Discovery ◽  
Antifungal Agent ◽  
Structural Elucidation ◽  
Microbial Genomics

scholarly journals Structural elucidation of ligand binding sites in family B GPCRs and their application in drug discovery 

2016 ◽  
Vol 72 (a1) ◽  
pp. s24-s24
Author(s):  
Ali Jazayeri ◽  
Andrew Doré ◽  
Daniel Lamb ◽  
Harini Krishnamurthy ◽  
Stacey Southall ◽  
...  
Keyword(s):  
Drug Discovery ◽  
Ligand Binding ◽  
Binding Sites ◽  
Structural Elucidation ◽  
Ligand Binding Sites

Software-aided structural elucidation in drug discovery

2015 ◽  
Vol 29 (21) ◽  
pp. 2083-2089 ◽  
Author(s):  
Marie Ahlqvist ◽  
Carina Leandersson ◽  
Martin A. Hayes ◽  
Ismael Zamora ◽  
Richard A. Thompson
Keyword(s):  
Drug Discovery ◽  
Structural Elucidation

scholarly journals L-657,398, a novel antifungal agent: Fermentation, isolation, structural elucidation and biological properties.

1988 ◽  
Vol 41 (12) ◽  
pp. 1774-1779 ◽  
Author(s):  
ROBERT E. SCHWARTZ ◽  
JERROLD LIESCH ◽  
OTTO HENSENS ◽  
LAURETTA ZITANO ◽  
SUE HONEYCUTT ◽  
...  
Keyword(s):  
Antifungal Agent ◽  
Biological Properties ◽  
Structural Elucidation

Total Synthesis and Structural Elucidation of the Antifungal Agent Papulacandin D

1996 ◽  
Vol 61 (3) ◽  
pp. 1082-1100 ◽  
Author(s):  
Anthony G. M. Barrett ◽  
Michael Peña ◽  
J. Adam Willardsen
Keyword(s):  
Total Synthesis ◽  
Antifungal Agent ◽  
Structural Elucidation

Lasso peptides: chemical approaches and structural elucidation

2018 ◽  
Vol 16 (28) ◽  
pp. 5065-5080 ◽  
Author(s):  
Helena Martin-Gómez ◽  
Judit Tulla-Puche
Keyword(s):  
Drug Discovery ◽  
Structural Elucidation ◽  
Lasso Peptides

The diverse functionality and the extraordinary stability of lasso peptides make these molecules attractive scaffolds for drug discovery. The ability to generate lasso peptides chemically remains a challenging endeavor.

scholarly journals Genomics and drug discovery

2002 ◽  
Vol 23 (5) ◽  
pp. 17
Author(s):  
Stuart L Hazell
Keyword(s):  
Drug Discovery ◽  
Molecular Biology ◽  
Genomic Data ◽  
Genetic Data ◽  
Microbial Genomics ◽  
Whole Cell ◽  
New Era ◽  
Complete Answer ◽  
Quantum Leap

Genomics represents a new tool in drug discovery. Microbial genomics have been at the forefront of a new era of whole cell molecular biology because genomic data provides a quantum leap in available genetic data. But while the tool is valuable and important, it is not the complete answer.

ChemInform Abstract: Total Synthesis and Structural Elucidation of the Antifungal Agent Papulacandin D (I).

ChemInform ◽  
2010 ◽  
Vol 27 (27) ◽  
pp. no-no
Author(s):  
A. G. M. BARRETT ◽  
M. PENA ◽  
J. A. WILLARDSEN
Keyword(s):  
Total Synthesis ◽  
Antifungal Agent ◽  
Structural Elucidation
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