N-Methyl-2,3,6-Trimethoxymorphinandien-7-one N-oxide: A Minor Alkaloid from Alseodaphne perakensts

1991 ◽  
Vol 54 (2) ◽  
pp. 612-614 ◽  
Author(s):  
Nordin H. Lajis ◽  
Zurina Mahmud ◽  
Robert F. Toia
Keyword(s):  
A Minor ◽  
Minor Alkaloid

ChemInform Abstract: MAPPICINE, A MINOR ALKALOID FROM MAPPIA FOETIDA MIERS

1974 ◽  
Vol 5 (34) ◽  
Author(s):  
TUTICORIN R. GOVINDACHARI ◽  
KONGOVI R. RAVINDRANATH ◽  
NARAYANAN VISWANATHAN
Keyword(s):  
A Minor ◽  
Minor Alkaloid

scholarly journals The identification of a minor alkaloid of Mackinlaya macrosciadia (Araliaceae) as deoxyvasicinone

1971 ◽  
Vol 24 (1) ◽  
pp. 223 ◽  
Author(s):  
NK Hart ◽  
SR Johns ◽  
JA Lamberton
Keyword(s):  
A Minor ◽  
Minor Alkaloid

Mappicine, a minor alkaloid from Mappia foetida miers

1974 ◽  
pp. 1215 ◽  
Author(s):  
Tuticorin R. Govindachari ◽  
Kongovi R. Ravindranath ◽  
Narayanan Viswanathan
Keyword(s):  
A Minor ◽  
Minor Alkaloid

N-Deacetyl-N-3-oxobutyrylcolchicine, an alkaloid from Colchicum autumnale L. seeds

1983 ◽  
Vol 48 (10) ◽  
pp. 2989-2993 ◽  
Author(s):  
František Šantavý ◽  
Petr Sedmera ◽  
Jindřich Vokoun ◽  
Svatava Dvoráčková ◽  
Vilím Šimánek
Keyword(s):  
Spectroscopic Measurements ◽  
Colchicum Autumnale ◽  
A Minor ◽  
Minor Alkaloid

The structure of N-deacetyl-N-3-oxobutyrylcolchicine (V), based on spectroscopic measurements, was proposed for a minor alkaloid isolated from seeds of Colchicum autumnale L.

Hippamine, a Minor Alkaloid From Sternbergia lutea

1984 ◽  
Vol 47 (6) ◽  
pp. 1061-1062 ◽  
Author(s):  
A. Evidente ◽  
I. Iasiello ◽  
G. Randazzo
Keyword(s):  
A Minor ◽  
Minor Alkaloid

Serpinine, a minor alkaloid ofRauwolfia Serpentina Benth

1955 ◽  
Vol 42 (3) ◽  
pp. 71-72 ◽  
Author(s):  
S. Bose
Keyword(s):  
A Minor ◽  
Minor Alkaloid

Macrantaline ? A minor alkaloid ofPapaver lisae

1979 ◽  
Vol 15 (2) ◽  
pp. 209-210
Author(s):  
V. V. Melik-Gusednov ◽  
D. A. Murav'eva ◽  
V. A. Mnatsakanyan
Keyword(s):  
A Minor ◽  
Minor Alkaloid

(+)-Angustifoline: A Minor Alkaloid fromLupinus albus1

Planta Medica ◽  
1993 ◽  
Vol 59 (03) ◽  
pp. 289-289 ◽  
Author(s):  
Waleria Wysocka ◽  
Anna Przybyt
Keyword(s):  
A Minor ◽  
Minor Alkaloid

Cell-Free Synthesis of the Alkaloids Ammodendrine and Smipine

1987 ◽  
Vol 42 (3) ◽  
pp. 197-204 ◽  
Author(s):  
Michael Wink ◽  
Ludger Witte
Keyword(s):  
Pisum Sativum ◽  
Plant Species ◽  
Diamine Oxidase ◽  
Quinolizidine Alkaloids ◽  
Lupinus Arboreus ◽  
A Minor ◽  
Minor Alkaloid ◽  
Reaction Schemes

The bipiperidyl alkaloid ammodendrine was detected in 28 plant species as a minor alkaloid besides quinolizidine alkaloids. Cadaverine serves as a precursor for both quinolizidine alkaloids and for ammodendrine, since labelled cadaverine is incorporated into both rings of ammoden­drine. Cell-free extracts of Lupinus arboreus and of Pisum sativum, which contain an active diamine oxidase form ammodendrine from cadaverine and pyruvate. In addition to ammoden­drine other alkaloids such as smipine, tetrahydroanabasine and tripiperideine could be detected. Possible reaction schemes are discussed.

scholarly journals Cotinine: Pharmacologically Active Metabolite of Nicotine and Neural Mechanisms for Its Actions

2021 ◽  
Vol 15 ◽  
Author(s):  
Xiaoying Tan ◽  
Kent Vrana ◽  
Zheng-Ming Ding
Keyword(s):  
Nicotinic Acetylcholine Receptors ◽  
Acetylcholine Receptors ◽  
Premature Death ◽  
The United States ◽  
Public Health Issue ◽  
Tobacco Addiction ◽  
Pharmacologically Active ◽  
A Minor ◽  
Minor Alkaloid ◽  
Insight Into

Tobacco use disorder continues to be a leading public health issue and cause of premature death in the United States. Nicotine is considered as the major tobacco alkaloid causing addiction through its actions on nicotinic acetylcholine receptors (nAChRs). Current pharmacotherapies targeting nicotine’s effects produce only modest effectiveness in promoting cessation, highlighting the critical need for a better understanding of mechanisms of nicotine addiction to inform future treatments. There is growing interest in identifying potential contributions of non-nicotine components to tobacco reinforcement. Cotinine is a minor alkaloid, but the major metabolite of nicotine that can act as a weak agonist of nAChRs. Accumulating evidence indicates that cotinine produces diverse effects and may contribute to effects of nicotine. In this review, we summarize findings implicating cotinine as a neuroactive metabolite of nicotine and discuss available evidence regarding potential mechanisms underlying its effects. Preclinical findings reveal that cotinine crosses the blood brain barrier and interacts with both nAChRs and non-nAChRs in the nervous system, and produces neuropharmacological and behavioral effects. Clinical studies suggest that cotinine is psychoactive in humans. However, reviewing evidence regarding mechanisms underlying effects of cotinine provides a mixed picture with a lack of consensus. Therefore, more research is warranted in order to provide better insight into the actions of cotinine and its contribution to tobacco addiction.

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