Development and Scale-Up of Cocrystals Using Resonant Acoustic Mixing

We present a methodology for the rapid and readily scalable mechanosynthesis of diverse metal-organic frameworks (MOFs) in the absence of milling media, typically required for other types of mechanochemical syntheses. We demonstrate the use of liquid-assisted resonant acoustic mixing (LA-RAM) methodology for the synthesis of two- and three-dimensional MOFs based on Zn, Co(II) and Cu(II), including single- and mixed-ligand systems, imidazolate or carboxylate ligands. The LA-RAM approach also allowed the synthesis of the ZIF-L, a framework never previously obtained in a solventless environment, as well as its Co(II) analogue. Straightforward scale-up from milligrams to at least 25 grams is demonstrated using ZIF-L as the model.<br>

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High-throughput screening and scale-up of cocrystals using resonant acoustic mixing

International Journal of Pharmaceutics ◽

10.1016/j.ijpharm.2017.02.027 ◽

2017 ◽

Vol 521 (1-2) ◽

pp. 337-345 ◽

Cited By ~ 18

Author(s):

Karthik Nagapudi ◽

Evelyn Yanez Umanzor ◽

Colin Masui

Keyword(s):

High Throughput ◽

High Throughput Screening ◽

Scale Up ◽

Resonant Acoustic Mixing

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Simple, Scalable Mechanosynthesis of Metal-Organic Frameworks Using Liquid-Assisted Resonant Acoustic Mixing (LA-RAM)

10.26434/chemrxiv.11577561 ◽

2020 ◽

Author(s):

Hatem M. Titi ◽

Jean-Louis Do ◽

Ashlee J. Howarth ◽

Karthik Nagapudi ◽

Tomislav Friscic

Keyword(s):

Metal Organic Frameworks ◽

Scale Up ◽

Three Dimensional ◽

Mixed Ligand ◽

Carboxylate Ligands ◽

Metal Organic ◽

Resonant Acoustic Mixing

We present a methodology for the rapid and readily scalable mechanosynthesis of diverse metal-organic frameworks (MOFs) in the absence of milling media, typically required for other types of mechanochemical syntheses. We demonstrate the use of liquid-assisted resonant acoustic mixing (LA-RAM) methodology for the synthesis of two- and three-dimensional MOFs based on Zn, Co(II) and Cu(II), including single- and mixed-ligand systems, imidazolate or carboxylate ligands. The LA-RAM approach also allowed the synthesis of the ZIF-L, a framework never previously obtained in a solventless environment, as well as its Co(II) analogue. Straightforward scale-up from milligrams to at least 25 grams is demonstrated using ZIF-L as the model.<br>

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NiAl precipitation in Fe-12w/o Cr-5w/o Ni-4w/o Al

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s042482010007480x ◽

1983 ◽

Vol 41 ◽

pp. 202-203

Author(s):

L.E. Murr ◽

J.S. Dunning ◽

S. Shankar

Keyword(s):

Solid Solution ◽

Stainless Steel ◽

Stainless Steels ◽

Alloy Composition ◽

Chromium Content ◽

Scale Up ◽

Optical Metallography ◽

Property Evaluation ◽

310 Stainless Steel ◽

Microstructural Studies

Aluminum additions to conventional 18Cr-8Ni austenitic stainless steel compositions impart excellent resistance to high sulfur environments. However, problems are typically encountered with aluminum additions above about 1% due to embrittlement caused by aluminum in solid solution and the precipitation of NiAl. Consequently, little use has been made of aluminum alloy additions to stainless steels for use in sulfur or H2S environments in the chemical industry, energy conversion or generation, and mineral processing, for example.A research program at the Albany Research Center has concentrated on the development of a wrought alloy composition with as low a chromium content as possible, with the idea of developing a low-chromium substitute for 310 stainless steel (25Cr-20Ni) which is often used in high-sulfur environments. On the basis of workability and microstructural studies involving optical metallography on 100g button ingots soaked at 700°C and air-cooled, a low-alloy composition Fe-12Cr-5Ni-4Al (in wt %) was selected for scale up and property evaluation.

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