High-Temperature Property Evaluation and Index Research of Modified Asphalt before and After Aging

In order to better evaluate the composite modified asphalt of composite modified asphalt, this study through dynamic shear rheological (DSR) test, the three kinds of polymer modified asphalt before and after ageing: the compound modified asphalt (CCR), rubber powder modified asphalt (CR) and composite modified asphalt of SBS modified asphalt (SBS) analysis, to explore suitable for composite modified asphalt of modified asphalt evaluation index. The results show that: Compared with G*/sinδ, G*/(sinδ)9 has higher accuracy for evaluating the composite modified asphalt of polymer modified asphalt and is more sensitive to changes in phase angle. The critical temperature of anti-rutting factor TG*/sinδ9 is significantly higher than that of TG*/sinδ, especially for composite modified asphalt. This has an important impact on the PG classification in the Superpave asphalt binder specification. G*/sinδ underestimates the high temperature grade of the modified asphalt. The equivalent viscosity measured with η’ = sinδ-4.8628 G*/ω has the best correlation with the anti-rutting factor G*/(sinδ)9, and the highest correlation coefficient is 0.999, which is more suitable as a high-temperature property evaluation index of modified asphalt.

Alloplastic and Implant Materials for Bone Grafting: a Literature Review

Bone reconstruction aft er trauma, infection, tumour or congenital genetic disorder is an important subject of modern medicine usually relying on bone graft ing materials. Autologous bone or autograft is still considered the “gold standard” most eff ective in bone defect reconstruction and osseous regeneration. Having the advantages of autograft ing, a series of issues remain related to a limited donor material, painful graft taking and the risk of putative complications (nonunions, graft rejection, infection, iatrogenic fractures, post-microsurgery arteriovenous shunt thrombosis, etc.). Th erefore, improved biomaterials are demanded to adequately meet the autograft criteria. Choosing optimal graft materials becomes relevant, aside to the rationale of selecting new surgical techniques. Th e osteoconductive and osteoinductive property evaluation in modern osteoplastic materials comprises a research avenue into optimal graft development for osseous correction in maxillofacial surgery, neurosurgery, traumatology and orthopaedics. Such biomaterials can be combined with alloplastic graft s to attain the required properties of osteoconduction, osteoinduction and osteogenesis. Th is analytic literature review focuses on current state-of-the-art in alloplastic graft ing that, in our opinion, grounds the progress of auto- and allograft innovative development.

Mechanical Properties of Cement Composites Using Modified Plastics by Gamma Irradiation

Recently, pollution caused by an increasing amount of worldwide plastic waste has become a global problem. However, these concerns can be alleviated by the use of gamma-ray technology. Using radiation technology, plastic wastes can be converted into a variety of useful purposes presenting powerful opportunities for environmental sustainability and material innovations. Plastics are strong, durable, waterproof, lightweight, easy to mold, and recyclable. In this study, plastic aggregate modified by gamma irradiation was mixed into cement composites, and mechanical property evaluation experiments were conducted. As a result, it was confirmed that the physical performance of cement composites was improved by up to 70% in the case of using the modified plastic aggregates compared to the general plastic aggregate.

An overview of kinase downregulators and recent advances in discovery approaches

Since the clinical approval of imatinib, the discovery of protein kinase downregulators entered a prosperous age. However, challenges still exist in the discovery of kinase downregulator drugs, such as the high failure rate during development, side effects, and drug-resistance problems. With the progress made through multidisciplinary efforts, an increasing number of new approaches have been applied to solve the above problems during the discovery process of kinase downregulators. In terms of in vitro and in vivo drug evaluation, progress was also made in cellular and animal model platforms for better and more clinically relevant drug assessment. Here, we review the advances in drug design strategies, drug property evaluation technologies, and efficacy evaluation models and technologies. Finally, we discuss the challenges and perspectives in the development of kinase downregulator drugs.