Stereoselective Lithiation and Carboxylation of Boc-Protected Bicyclopyrrolidine: Synthesis of a Key Building Block for HCV Protease Inhibitor Telaprevir

2014 ◽  
Vol 18 (10) ◽  
pp. 1234-1244 ◽  
Author(s):  
Gerald J. Tanoury ◽  
Minzhang Chen ◽  
Yong Dong ◽  
Raymond Forslund ◽  
Valdas Jurkauskas ◽  
...  
Keyword(s):  
Protease Inhibitor ◽  
Building Block ◽  
Hcv Protease ◽  
Protease Inhibitor Telaprevir

1244 THE PHARMACOKINETIC INTERACTION BETWEEN METHADONE AND THE INVESTIGATIONAL HCV PROTEASE INHIBITOR TELAPREVIR

2011 ◽  
Vol 54 ◽  
pp. S491-S492 ◽  
Author(s):  
R. van Heeswijk ◽  
A. Vandevoorde ◽  
P. Verboven ◽  
G. Boogaerts ◽  
E. De Paepe ◽  
...  
Keyword(s):  
Protease Inhibitor ◽  
Pharmacokinetic Interaction ◽  
Hcv Protease ◽  
Protease Inhibitor Telaprevir

Determination of the HCV Protease Inhibitor Telaprevir in Plasma and Dried Blood Spot by Liquid Chromatography–Tandem Mass Spectrometry

2015 ◽  
Vol 37 (5) ◽  
pp. 626-633 ◽  
Author(s):  
Corrien P. W. G. M. Verweij-van Wissen ◽  
Marga J. A. de Graaff-Teulen ◽  
Clara T. M. M. de Kanter ◽  
Rob E. Aarnoutse ◽  
David M. Burger
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Protease Inhibitor ◽  
Tandem Mass ◽  
Chromatography Tandem Mass Spectrometry ◽  
Liquid Chromatography Tandem Mass ◽  
Hcv Protease ◽  
Protease Inhibitor Telaprevir ◽  
Blood Spot

1245 THE EFFECT OF SEVERE RENAL IMPAIRMENT ON THE PHARMACOKINETICS OF THE INVESTIGATIONAL HCV PROTEASE INHIBITOR TELAPREVIR

2011 ◽  
Vol 54 ◽  
pp. S492 ◽  
Author(s):  
R. van Heeswijk ◽  
A. Vandevoorde ◽  
G. Boogaerts ◽  
E. De Paepe ◽  
R. van Solingen-Ristea ◽  
...  
Keyword(s):  
Renal Impairment ◽  
Protease Inhibitor ◽  
Severe Renal Impairment ◽  
Hcv Protease ◽  
Protease Inhibitor Telaprevir

Bioavailability of the HCV NS3/4A Protease Inhibitor Telaprevir–Effect of Different Types of Food

2012 ◽  
Vol 50 (01) ◽  
Author(s):  
R van Heeswijk ◽  
G Boogaerts ◽  
E De Paepe ◽  
T Vangeneugden ◽  
K De Backer
Keyword(s):  
Protease Inhibitor ◽  
Different Types ◽  
Protease Inhibitor Telaprevir
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