Proteome of Metastatic Canine Mammary Carcinomas: Similarities to and Differences from Human Breast Cancer†

2010 ◽  
Vol 9 (12) ◽  
pp. 6380-6391 ◽  
Author(s):  
Robert Klopfleisch ◽  
Patricia Klose ◽  
Christoph Weise ◽  
Angelika Bondzio ◽  
Gerd Multhaup ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Human Breast Cancer ◽  
Human Breast ◽  
Mammary Carcinomas

PD08-10: High Frequency of Triple Negative Mammary Carcinomas in the Dog as Model of Human Breast Cancer.

2011 ◽  
Author(s):  
F Nguyen ◽  
J Abadie ◽  
D Loussouarn ◽  
C Ibisch ◽  
N Rieder ◽  
...  
Keyword(s):  
Breast Cancer ◽  
High Frequency ◽  
Human Breast Cancer ◽  
Triple Negative ◽  
Human Breast ◽  
Mammary Carcinomas

Abstract B43: NF1 deficiency induces aggressive mammary carcinomas in a CRISPR rat model and correlates with poor outcome in sporadic human breast cancer

2018 ◽  
Author(s):  
Patrick Dischinger ◽  
Elizabeth Tovar ◽  
Curt Essenburg ◽  
Eve Gardner ◽  
Megan Callaghan ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Rat Model ◽  
Human Breast Cancer ◽  
Human Breast ◽  
Mammary Carcinomas ◽  
Poor Outcome

scholarly journals Tumor Infiltrating Lymphocytes in Pet Rabbit Mammary Carcinomas: A Study with Relevance to Comparative Pathology

Animals ◽  
2020 ◽  
Vol 10 (8) ◽  
pp. 1437 ◽  
Author(s):  
Sandra Schöniger ◽  
Sophie Degner ◽  
Qian Zhang ◽  
Claudia Schandelmaier ◽  
Heike Aupperle-Lellbach ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Human Breast Cancer ◽  
Tumor Infiltrating Lymphocytes ◽  
Mitotic Count ◽  
Human Breast ◽  
Human Immune System ◽  
Mammary Carcinomas ◽  
Cancer Data ◽  
Microscopic Evaluation ◽  
Infiltrating Lymphocytes

Tumor infiltrating lymphocytes (TILs) serve as prognostic biomarker in human breast cancer. Rabbits have the potential to act as animal model for human breast cancer, and close similarities exist between the rabbit and human immune system. The aim of this study is to characterize TILs in pet rabbit mammary carcinomas and to statistically correlate results with histological and immunohistochemical tumor characteristics. Microscopic evaluation of TILs was performed in hematoxylin and eosin stained sections of 107 rabbit mammary carcinomas according to international guidelines for human breast cancer. Data on histological features of malignancy, estrogen and progesterone receptor status and calponin expression were obtained from the data base. This study revealed a statistical association between stromal TILs in the central tumor (CT) and infiltrative margin. Higher maximal percentages of stromal TILs at the CT were statistically correlated with decreased mitotic count and lower tumor grade. An increased number of calponin positive tumor cells was statistically associated with a lower mitotic count and a higher percentage of stromal TILs. Results suggest that higher percentages of stromal TILs are useful biomarkers that may point toward a favorable prognosis in rabbit mammary carcinomas and support the concept of the use of rabbits for translational research.

scholarly journals Canine invasive mammary carcinomas as models of human breast cancer. Part 1: natural history and prognostic factors

2017 ◽  
Vol 167 (3) ◽  
pp. 635-648 ◽  
Author(s):  
Frédérique Nguyen ◽  
Laura Peña ◽  
Catherine Ibisch ◽  
Delphine Loussouarn ◽  
Adelina Gama ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Prognostic Factors ◽  
Natural History ◽  
Human Breast Cancer ◽  
Human Breast ◽  
Mammary Carcinomas

scholarly journals One‐year conditional survival of dogs and cats with invasive mammary carcinomas: A concept inspired from human breast cancer

2020 ◽  
Author(s):  
Florian Chocteau ◽  
Valentin Mordelet ◽  
Elie Dagher ◽  
Delphine Loussouarn ◽  
Jérôme Abadie ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Human Breast Cancer ◽  
Conditional Survival ◽  
Human Breast ◽  
Mammary Carcinomas ◽  
One Year

scholarly journals Canine invasive mammary carcinomas as models of human breast cancer. Part 2: immunophenotypes and prognostic significance

2017 ◽  
Vol 167 (2) ◽  
pp. 459-468 ◽  
Author(s):  
Jérôme Abadie ◽  
Frédérique Nguyen ◽  
Delphine Loussouarn ◽  
Laura Peña ◽  
Adelina Gama ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Human Breast Cancer ◽  
Prognostic Significance ◽  
Human Breast ◽  
Mammary Carcinomas

Virus-Like Particles in a Human Breast Cancer: Structural Similarity to Previously Reported Particles

1973 ◽  
Vol 31 ◽  
pp. 378-379
Author(s):  
G. Kasnic ◽  
S. E. Stewart ◽  
C. Urbanski
Keyword(s):  
Breast Cancer ◽  
Biological Activity ◽  
Human Breast Cancer ◽  
Osteogenic Sarcoma ◽  
Human Tumor ◽  
Structural Similarity ◽  
Cell Tumor ◽  
Human Breast ◽  
Human Tumor Cell ◽  
Type Particle

We have reported the maturation of an intracisternal A-type particle in murine plasma cell tumor cultures and three human tumor cell cultures (rhabdomyosarcoma, lung adenocarcinoma, and osteogenic sarcoma) after IUDR-DMSO activation. In all of these studies the A-type particle seems to develop into a form with an electron dense nucleoid, presumably mature, which is also intracisternal. A similar intracisternal A-type particle has been described in leukemic guinea pigs. Although no biological activity has yet been demonstrated for these particles, on morphologic grounds, and by the manner in which they develop within the cell, they may represent members of the same family of viruses.

Further Ultrastructural Observations on Metastatic Nodules of Human Breast Cancer

1968 ◽  
Vol 26 ◽  
pp. 224-225
Author(s):  
John L. Swedo ◽  
R. W. Talley ◽  
John H. L. Watson
Keyword(s):  
Breast Cancer ◽  
Human Breast Cancer ◽  
Estrogen Therapy ◽  
Specimen Preparation ◽  
Human Breast ◽  
Autophagic Vacuoles ◽  
Previous Communication ◽  
Linear Profiles ◽  
Metastatic Nodule

Since the report, which described the ultrastructure of a metastatic nodule of human breast cancer after estrogen therapy, additional ultrastructural observations, including some which are correlative with pertinent findings in the literature concerning mycoplasmas, have been recorded concerning the same subject. Specimen preparation was identical to that in.The mitochondria possessed few cristae, and were deteriorated and vacuolated. They often contained particulates and fibrous structures, sometimes arranged in spindle-shaped bundles, Fig. 1. Another apparent aberration was the occurrence, Fig. 2 (arrows) of linear profiles of what seems to be SER, which lie between layers of RER, and are often recognizably continuous with them.It was noted that the structure of the round bodies, interpreted as within autophagic vacuoles in the previous communication, and of vesicular bodies, described morphologically closely resembled those of some mycoplasmas. Specifically, they simulated or reflected the various stages of replication reported for mycoplasmas grown on solid nutrient. Based on this observation, they are referred to here as “mycoplasma-like” structures, in anticipation of confirmatory evidence from investigations now in progress.

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