Regulation of Expression ofN-Methylpurine DNA Glycosylase in Human Mammary Epithelial Cells:  Role of Transcription Factor AP-2

1999 ◽  
Vol 12 (11) ◽  
pp. 1098-1109 ◽  
Author(s):  
Sonia R. Cerda ◽  
Samuel S. Chu ◽  
Pablo Garcia ◽  
Jean Chung ◽  
Jordan D. Grumet ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Epithelial Cells ◽  
Mammary Epithelial Cells ◽  
Mammary Epithelial ◽  
Dna Glycosylase ◽  
Regulation Of Expression ◽  
Human Mammary Epithelial Cells ◽  
Human Mammary Epithelial ◽  
Methylpurine Dna Glycosylase

scholarly journals A functional screen for genes inducing epidermal growth factor autonomy of human mammary epithelial cells confirms the role of amphiregulin

Oncogene ◽  
2001 ◽  
Vol 20 (30) ◽  
pp. 4019-4028 ◽  
Author(s):  
Isabelle M Berquin ◽  
Michele L Dziubinski ◽  
Garry P Nolan ◽  
Stephen P Ethier
Keyword(s):  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Epithelial Cells ◽  
Mammary Epithelial Cells ◽  
Mammary Epithelial ◽  
Human Mammary Epithelial Cells ◽  
Functional Screen ◽  
Human Mammary Epithelial ◽  
Epidermal Growth

Abstract 4177: Synergistic role of ecdysoneless with oncogenic Ras in transformation of human mammary epithelial cells

2012 ◽  
Author(s):  
Aditya Bele ◽  
Channabasavaiah Basavaraju Gurumurthy ◽  
Xiangshan Zhao ◽  
Jun Wang ◽  
Sameer Mirza ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Mammary Epithelial Cells ◽  
Mammary Epithelial ◽  
Human Mammary Epithelial Cells ◽  
Oncogenic Ras ◽  
Human Mammary Epithelial

scholarly journals Human Papillomavirus Type 16 E6-Induced Degradation of E6TP1 Correlates with Its Ability To Immortalize Human Mammary Epithelial Cells

2001 ◽  
Vol 75 (9) ◽  
pp. 4459-4466 ◽  
Author(s):  
Qingshen Gao ◽  
Latika Singh ◽  
Ajay Kumar ◽  
Seetha Srinivasan ◽  
David E. Wazer ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Epithelial Cells ◽  
Mammary Epithelial Cells ◽  
Cellular Transformation ◽  
Mammary Epithelial ◽  
Human Mammary Epithelial Cells ◽  
Human Papillomavirus Type 16 ◽  
Human Mammary Epithelial ◽  
E6 Protein

ABSTRACT Recent analyses have identified a number of binding partners for E6, including E6AP, ERC55, paxillin, hDlg, p300, interferon regulatory factor 3, hMCM7, Bak, and E6TP1. Notably, association with E6 targets p53, E6TP1, myc, hMCM7, and Bak for degradation. However, the relative importance of the various E6 targets in cellular transformation remains unclear. E6 alone can dominantly immortalize normal human mammary epithelial cells (MECs), permitting an assessment of the importance of various E6 targets in cellular transformation. Studies in this system indicate that E6-induced degradation of p53 and E6 binding to ERC55 or hDlg do not correlate with efficient immortalization. Here, we have examined the role of E6TP1, a Rap GTPase-activating protein, in E6-induced immortalization of MECs. We tested a large set of human papillomavirus type 16 E6 mutants for their ability to bind and target E6TP1 for degradation in vitro and in vivo. We observed a strict correlation between the ability of E6 protein to target E6TP1 for degradation and its ability to immortalize MECs. Recent studies have identified telomerase as a target of E6 protein. Previous analyses of E6 mutants have revealed this trait to closely correlate with MEC immortalization. We examined our entire panel of E6 mutants for rapid induction of telomerase activity and found in general a strong correlation with immortalizing ability. The tight correlation between E6TP1 degradation and MEC immortalization strongly supports a critical role of functional inactivation of E6TP1 in E6-induced cellular immortalization.

scholarly journals Tumor suppressor role of cytoplasmic polyadenylation element binding protein 2 (CPEB2) in human mammary epithelial cells

BMC Cancer ◽  
2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Joshua Tordjman ◽  
Mousumi Majumder ◽  
Mehdi Amiri ◽  
Asma Hasan ◽  
David Hess ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Epithelial Cells ◽  
Mammary Epithelial Cells ◽  
Binding Protein ◽  
Mammary Epithelial ◽  
Cytoplasmic Polyadenylation ◽  
Human Mammary Epithelial Cells ◽  
Human Mammary Epithelial ◽  
Element Binding Protein

scholarly journals Role of DNA repair in malignant neoplastic transformation of human mammary epithelial cells in culture

1992 ◽  
Vol 13 (7) ◽  
pp. 1137-1141 ◽  
Author(s):  
Katherine K. Sanford ◽  
Floyd M. Price ◽  
Johng S. Rhim ◽  
Martha R. Stampfer ◽  
Ram Parshad
Keyword(s):  
Dna Repair ◽  
Epithelial Cells ◽  
Mammary Epithelial Cells ◽  
Neoplastic Transformation ◽  
Mammary Epithelial ◽  
Human Mammary Epithelial Cells ◽  
Cells In Culture ◽  
Human Mammary Epithelial

Human mammary epithelial cells are sensitized to ionizing radiation by knockdown of caveolin-1

2010 ◽  
Vol 34 (8) ◽  
pp. S7-S7
Author(s):  
Nan Zhang ◽  
Jian Che ◽  
Zheng Wu ◽  
Yang Wang ◽  
Liwei Liu ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Ionizing Radiation ◽  
Mammary Epithelial Cells ◽  
Mammary Epithelial ◽  
Caveolin 1 ◽  
Human Mammary Epithelial Cells ◽  
Human Mammary Epithelial
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